{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:50:47Z","timestamp":1761709847881,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The purpose of this study was to explore the value of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in monitoring the disease activity and predicting the prognosis of the Adult-onset Still's disease (AOSD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We retrospectively analyzed the electronic medical records of 45 AOSD patients who underwent <jats:sup>18<\/jats:sup>F-FDG PET\/CT in the Second Xiangya Hospital. PET\/CT imaging and clinical information were retrospectively reviewed and analyzed. <jats:sup>18<\/jats:sup>F-FDG uptake was assessed by measuring standard uptake value (SUV) in the spleen, liver, bone marrow, and lymph nodes. The spleen-to-liver ratio of the SUVmax (SLRmax) and SUVmean (SLRmean), the bone-to-liver ratio of the SUVmax (BLRmax), and SUVmean (BLRmean), and the lymph nodes-to-liver ratio of the SUVmax (LyLRmax) were calculated. Clinical and laboratory information were collected and evaluated for association with metabolic parameters of <jats:sup>18<\/jats:sup>F-FDG PET\/CT. The influencing factors for recurrence within 1 year were analyzed to determine whether <jats:sup>18<\/jats:sup>F-FDG PET\/CT can predict the prognosis of AOSD patients.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Elevated <jats:sup>18<\/jats:sup>F-FDG uptake could be observed in bone marrow, spleen, and lymph nodes of AOSD patients. Correlation analysis between <jats:sup>18<\/jats:sup>F-FDG uptake of organs and laboratory examinations showed that SLRmean positively correlated with LDH, AST, ferritin, and the systemic score (<jats:italic>r<\/jats:italic> = 0.572, 0.353, 0.586, and 0.424, <jats:italic>P<\/jats:italic> &amp;lt; 0.05). The SLRmean had the highest correlation with ferritin (<jats:italic>r<\/jats:italic> = 0586, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). All metabolic parameters in spleen, including SUVmax, SUVmean, SLRmax, and SLRmean, are positively correlated with LDH level (<jats:italic>r<\/jats:italic> = 0.405, 0.539, 0.481, and 0.572, <jats:italic>P<\/jats:italic> &amp;lt; 0.05). Bone marrow SUVmax, BLRmax, and BLRmean were correlated with C-reactive protein (CRP) level (<jats:italic>r<\/jats:italic> = 0.395, 0.437, and 0.469, <jats:italic>P<\/jats:italic> &amp;lt; 0.05). Analysis of the influencing factors of recurrence within 1 year showed that the spleen SUVmax, spleen SUVmean, SLRmax, SLRmean, ferritin, and the systemic score of the recurrence group was significantly higher than the non-recurrence group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The SLRmean cutoff of 1.66 with a sensitivity of 72.7% and specificity of 80.0% had the highest performance in predicting recurrence.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The glucose metabolism of the liver, spleen, and bone marrow of AOSD patients were correlated with laboratory inflammatory indicators and system score, suggesting that <jats:sup>18<\/jats:sup>F-FDG PET\/CT could be applied to evaluate disease activity. Moreover, spleen <jats:sup>18<\/jats:sup>F-FDG uptake may be a potential biomarker for predicting clinical prognosis of AOSD patients.<\/jats:p>","DOI":"10.3389\/fmed.2021.668323","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T04:20:14Z","timestamp":1620706814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["18F-FDG PET\/CT Associates With Disease Activity and Clinical Recurrence of AOSD 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