{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:35:11Z","timestamp":1771472111044,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"Background:<\/jats:bold> Immunity against Pasteurella<\/jats:italic> spp. is not well-known for humans.<\/jats:p>Methods:<\/jats:bold> We've tested T CD8+ lymphocytes in a patient with a chronic prosthetic joint infection due to Pasteurella<\/jats:italic> spp. to search for a deficit which could have favored her infection. As this deficit was found, we've searched for such a deficit in other patients with Pasteurella<\/jats:italic> spp. Infections, either acute or subacute.<\/jats:p>Results:<\/jats:bold> Eight patients were tested and all had a persistent T CD8+ lymphocytes deficit. This is striking as these cells are involved in the response to this type of infection in animal models.<\/jats:p>Conclusion:<\/jats:bold> The authors suggest that a deficit in CD8+ T lymphocytes can be one of the causes for the onset of infections with P. multocida<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fmed.2021.668976","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T04:51:23Z","timestamp":1619499083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: CD8+ T-Lymphocyte Deficit: A Prerequisite for Pasteurella spp. Infection?"],"prefix":"10.3389","volume":"8","author":[{"given":"Eric","family":"Denes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Fiorenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateo","family":"Armendariz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1056\/NEJM199901143400202","article-title":"Bacteriologic analysis of infected dog and cat bites. 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