{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:29:54Z","timestamp":1779114594142,"version":"3.51.4"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The association between endometriosis and embryological outcomes remains uncertain. The meta-analysis aimed to evaluate the impact of endometriosis on embryo quality.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A systematic review and meta-analysis was conducted to investigate the association between the endometriosis and embryo quality. Searches were performed on the three electronic databases: PubMed, EMBASE, and Web of Science. The detailed characteristics and data of the included studies were extracted. The risk ratio with 95% confidence intervals were calculated using the random and fixed effects model. The main outcome measures were high-quality embryo rate, cleavage rate, and embryo formation rate.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 22 studies included were analyzed. Compared with the control group, women with endometriosis had a similar high-quality embryo rate (RR = 1.00; 95% CI, 0.94\u20131.06), a comparable cleavage rate (RR = 1.00; 95% CI, 0.97\u20131.02), and a similar embryo formation rate (RR = 1.10; 95% CI, 0.97\u20131.24). In women with stage III-IV endometriosis, there was no statistically significantly difference in high-quality embryo rate (RR = 1.02; 95% CI, 0.94\u20131.10), cleavage rate (RR = 1.00; 95% CI, 0.98\u20131.02), and embryo formation rate (RR = 1.05; 95% CI, 0.97\u20131.14), compared with those without endometriosis. For women with unilateral endometrioma, pooling of results from the affected ovaries did not show a statistically significantly difference in high-quality embryo rate (RR = 0.99; 95% CI, 0.60\u20131.63) in comparison to the normal contralateral ovaries.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our results seem to indicate that endometriosis does not compromise embryo quality from the perspective of morphology.<\/jats:p>","DOI":"10.3389\/fmed.2021.669342","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T06:37:19Z","timestamp":1622615839000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["The Impact of Endometriosis on Embryo Quality in in-vitro Fertilization\/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"8","author":[{"given":"Houjin","family":"Dongye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/j.fertnstert.2020.08.1431","article-title":"Effects of endometriosis on assisted reproductive technology: gone with the wind","volume":"8","author":"Pirtea","year":"2020","journal-title":"Fertil Steril"},{"key":"B3","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: pathophysiology and management","volume":"376","author":"de Ziegler","year":"2010","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum Reprod"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/1471-0528.12366","article-title":"The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis","volume":"120","author":"Harb","year":"2013","journal-title":"Bjog"},{"key":"B6","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/humupd\/dmv035","article-title":"The impact of endometrioma on IVF\/ICSI outcomes: a systematic review and meta-analysis","volume":"21","author":"Hamdan","year":"2015","journal-title":"Hum Reprod Update"},{"key":"B7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fendo.2020.00427","article-title":"Analysis of IVF\/ICSI-FET outcomes in women with advanced endometriosis: influence on ovarian response and oocyte competence","volume":"11","author":"Li","year":"2020","journal-title":"Front Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"20083","DOI":"10.3390\/diagnostics10020083","article-title":"Does endometriosis influence the embryo quality and\/or development? 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