{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:21:04Z","timestamp":1791562864395,"version":"4.3.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Exertional heat stroke (EHS) is a life-threatening injury that can lead to acute kidney injury (AKI). The clinical characteristics of and risk factors for EHS complicated with AKI have been poorly documented.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A retrospective study with EHS admitted to the intensive care unit (ICU) from January 2008 to June 2019 was performed. Data including baseline clinical information at admission, main organ dysfunction, 90-day mortality and total cost of hospitalization were collected.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 187 patients were finally included, of which 82 (43.9%) had AKI. AKI patients had more severe organ injury and higher total hospitalization costs than non-AKI patients. Multivariate logistic analysis showed that lymphocyte, neutrophil, D-dimer and myoglobin (MB) \u2265 1,000 ng\/ml were independent risk factors for AKI caused by EHS. In addition, SOFA score [hazard ratio (HR) 4.1, 95% confidence interval (95% CI) 1.6\u201310.8, <jats:italic>P<\/jats:italic> = 0.004] and GCS score (HR 3.2, 95% CI 1.2\u20138.4 <jats:italic>P<\/jats:italic> = 0.017) were the risk factor for 90-day mortality in patients with EHS complicated with AKI, with an area under the curve (AUC) of 0.920 (95% CI 0.842\u20130.998, <jats:italic>P<\/jats:italic> &amp;lt; 0.001) and 0.851 (95% CI 0.739\u20130.962, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), respectively. Survival analysis showed that the 90-day mortality in AKI patients was significantly high (<jats:italic>P<\/jats:italic> &amp;lt; 0.0001) and the mortality rate of patients with AKI stage 2 was the highest than other stages.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> EHS complicated with AKI is associated with higher hospitalization costs and poorly clinical outcomes. MB \u22651,000 ng\/ml, Inflammation, coagulation were associated with the occurrence and development of AKI. Early treatment strategies based reducing the SOFA and GCS score may be pivotal for improving the prognosis of EHS.<\/jats:p>","DOI":"10.3389\/fmed.2021.678434","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T05:55:25Z","timestamp":1621403725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Clinical Characteristics and Risk Factors Associated With Acute Kidney Injury Inpatient With Exertional Heatstroke: An Over 10-Year Intensive Care 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