{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:12:14Z","timestamp":1784243534874,"version":"3.55.0"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Aim:<\/jats:bold> To compare the clinical and radiological characteristics of osteomalacia and spondyloarthritis\/ankylosing spondylitis (SpA\/AS) in order to provide a basis for differential diagnosis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We carried out a retrospective analysis of patients who were diagnosed with osteomalacia at the First Medical Center of 301 Hospital (Beijing, China) from January 2012 to January 2019. The clinical and radiological data of all patients were collected; at the same time, we selected age- and gender-matched patients with SpA\/AS for comparison.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We enrolled a total of 76 patients, 38 with osteomalacia, and 38 with SpA\/AS. The mean ages of the two groups were, respectively 44.62 \u00b1 14.90 years and 44.85 \u00b1 9.76 years (<jats:italic>P<\/jats:italic> &amp;gt; 0.05). Of patients with osteomalacia, 65.79% (<jats:italic>n<\/jats:italic> = 25) had previously been misdiagnosed with SpA\/AS. In the osteomalacia and SpA\/AS groups, there were, respectively 31 and 33 patients with low back pain, 22 and 13 patients with peripheral arthralgia, and 13 and 3 patients with heel pain. Alkaline phosphatase (ALP) level was significantly higher in the osteomalacia than in the SpA\/AS group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Serum phosphorus levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, and bone mineral density (BMD) were significantly lower in the osteomalacia group than the SpA\/AS group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Twenty-five patients in the osteomalacia group underwent sacroiliac-joint magnetic-resonance imaging (SIJ\u2013MRI); abnormalities were found in 10 of these patients, seven of whom met the definition for positive SIJ\u2013MRI according to 2009 Assessment of SpondyloArthritis international Society (ASAS) criteria. All seven presented with bilateral sacral involvement. Logistic-regression analysis found that the odds ratio (OR) for bone erosion score was 0.551; the higher this score, the lower the possibility of osteomalacia.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Clinical and radiological presentations of patients with osteomalacia could highly simulate those of patients with spondyloarthritis; identifying the differences between these two diseases could effectively decrease the misdiagnosis rate.<\/jats:p>","DOI":"10.3389\/fmed.2021.680598","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T05:14:50Z","timestamp":1621487690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Analysis of Clinical and Imaging Features of Osteomalacia and Spondyloarthritis"],"prefix":"10.3389","volume":"8","author":[{"given":"Zheng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.berh.2003.09.004","article-title":"Musculoskeletal manifestations of osteomalacia and rickets","volume":"17","author":"Reginato","year":"2003","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.mpmed.2013.07.012","article-title":"Rickets and osteomalacia","volume":"41","author":"Whyte","year":"2013","journal-title":"Medicine."},{"key":"B3","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1507\/endocrj.EJ15-0289","article-title":"Pathogenesis and diagnostic criteria for rickets and osteomalacia \u2014Proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society","volume":"62","author":"Seiji","year":"2015","journal-title":"Endocrine J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jsbmb.2012.11.018","article-title":"Nutritional rickets around the world","volume":"136","author":"Prentice","year":"2013","journal-title":"J Steroid Biochem Mol Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.semarthrit.2017.12.001","article-title":"Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: a systematic review and meta-analysis","volume":"48","author":"Ram\u00edreza","year":"2018","journal-title":"Semin Arthritis Rheum."},{"key":"B6","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1136\/annrheumdis-2019-215589","article-title":"MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group","volume":"78","author":"Maksymowych","year":"2019","journal-title":"Ann Rheum Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tem.2009.02.001","article-title":"Bone as an endocrine organ","volume":"20","author":"Fukumoto","year":"2009","journal-title":"Trends Endocrinol Metab."}],"container-title":["Frontiers in 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