{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:50:24Z","timestamp":1791517824874,"version":"4.3.4"},"reference-count":336,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion. Strikingly, autoantibody profiles in pemphigus correlate with clinical phenotypes. Mucosal-dominant pemphigus vulgaris (PV) is characterised by autoantibodies (PV-IgG) against Dsg3 whereas epidermal blistering in PV and pemphigus foliaceus (PF) is associated with autoantibodies against Dsg1. Therapy in pemphigus is evolving towards specific suppression of autoantibody formation and autoantibody depletion. Nevertheless, during the acute phase and relapses of the disease additional treatment options to stabilise desmosomes and thereby rescue keratinocyte adhesion would be beneficial. Therefore, the mechanisms by which autoantibodies interfere with adhesion of desmosomes need to be characterised in detail. Besides direct inhibition of Dsg adhesion, autoantibodies engage signalling pathways interfering with different steps of desmosome turn-over. With this respect, recent data indicate that autoantibodies induce separate signalling responses in keratinocytes<jats:italic>via<\/jats:italic>specific signalling complexes organised by Dsg1 and Dsg3 which transfer the signal of autoantibody binding into the cell. This hypothesis may also explain the different clinical pemphigus phenotypes.<\/jats:p>","DOI":"10.3389\/fmed.2021.701809","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T05:57:35Z","timestamp":1628488655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["Autoantibody-Specific Signalling in Pemphigus"],"prefix":"10.3389","volume":"8","author":[{"given":"Thomas","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Waschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17026","DOI":"10.1038\/nrdp.2017.26","article-title":"Pemphigus","volume":"3","author":"Kasperkiewicz","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/S0140-6736(19)31778-7","article-title":"Pemphigus","volume":"394","author":"Schmidt","year":"2019","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00418-008-0420-0","article-title":"The desmosome and pemphigus","volume":"130","author":"Waschke","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrm1356","article-title":"Working out the strength and flexibility of desmosomes","volume":"5","author":"Getsios","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7523","DOI":"10.1038\/s41467-018-07523-0","article-title":"Mechanical loading of desmosomes depends on the magnitude and orientation of external stress","volume":"9","author":"Price","year":"2018","journal-title":"Nat Commun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1083\/jcb.149.1.209","article-title":"The function of plakophilin 1 in desmosome assembly and actin filament organization","volume":"149","author":"Hatzfeld","year":"2000","journal-title":"J Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1083\/jcb.200303036","article-title":"Defining desmosomal plakophilin-3 interactions","volume":"161","author":"Bonn\u00e9","year":"2003","journal-title":"J Cell Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1007\/s00018-009-0139-7","article-title":"Desmosomal interactome in keratinocytes: a systems biology approach leading to an understanding of the pathogenesis of skin disease","volume":"66","author":"Cirillo","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1083\/jcb.200510038","article-title":"Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin","volume":"171","author":"Godsel","year":"2005","journal-title":"J Cell Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.1074\/jbc.M108765200","article-title":"Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling","volume":"277","author":"Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1083\/jcb.141.5.1229","article-title":"Defining the interactions between intermediate filaments and desmosomes","volume":"141","author":"Smith","year":"1998","journal-title":"J Cell Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1046\/j.1523-1747.2003.12234.x","article-title":"Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation","volume":"120","author":"Wu","year":"2003","journal-title":"J Invest Dermatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3109\/15419061.2013.876018","article-title":"Desmosomal adhesion in vivo","volume":"21","author":"Berika","year":"2014","journal-title":"Cell Commun Adhes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e53739","DOI":"10.1371\/journal.pone.0053739","article-title":"Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion","volume":"8","author":"Hartlieb","year":"2013","journal-title":"PLoS ONE"},{"key":"B15","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1111\/bjd.18237","article-title":"New ex vivo human oral mucosa model reveals that p38MAPK inhibition is not effective in preventing autoantibody-induced mucosal blistering in pemphigus","volume":"182","author":"Egu","year":"2019","journal-title":"Br J Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1056\/NEJM200007063430105","article-title":"Protection against pemphigus foliaceus by desmoglein 3 in neonates","volume":"343","author":"Wu","year":"2000","journal-title":"N Engl J Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1016\/j.jid.2016.07.013","article-title":"Prevalence and age distribution of pemphigus and pemphigoid diseases in Germany","volume":"136","author":"H\u00fcbner","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1365-2133.2012.11040.x","article-title":"Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis","volume":"167","author":"Yan","year":"2012","journal-title":"Br J Dermatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/tan.12796","article-title":"Human leukocyte antigen class II (DRB1 and DQB1) alleles and haplotypes frequencies in patients with pemphigus vulgaris among the Serbian population","volume":"87","author":"Zivanovic","year":"2016","journal-title":"HLA"},{"key":"B20","doi-asserted-by":"publisher","first-page":"7658","DOI":"10.1073\/pnas.87.19.7658","article-title":"Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris","volume":"87","author":"Ahmed","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"B21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10875-008-9244-x","article-title":"HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris","volume":"29","author":"Shams","year":"2009","journal-title":"J Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3389\/fmed.2018.00226","article-title":"The genetics of pemphigus vulgaris","volume":"5","author":"Vodo","year":"2018","journal-title":"Front Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s12026-018-8986-7","article-title":"Pemphigus group: overview, epidemiology, mortality, and comorbidities","volume":"66","author":"Kridin","year":"2018","journal-title":"Immunol Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1159\/000018030","article-title":"HLA class II allele associations in Korean patients with pemphigus","volume":"197","author":"Lee","year":"1998","journal-title":"Dermatology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/BF00206963","article-title":"The immunoglobulin heavy chain and disease association: application to pemphigus vulgaris","volume":"94","author":"Gibson","year":"1994","journal-title":"Hum Genet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/sj.gene.6363817","article-title":"Pemphigus is not associated with allotypic markers of immunoglobulin kappa","volume":"3","author":"Zitouni","year":"2002","journal-title":"Genes Immun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1172\/JCI64413","article-title":"Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface","volume":"122","author":"Di Zenzo","year":"2012","journal-title":"J Clin Invest"},{"key":"B28","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.jid.5701132","article-title":"Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies","volume":"128","author":"Ishii","year":"2008","journal-title":"J Invest Dermatol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pharmthera.2003.07.002","article-title":"Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response","volume":"100","author":"Collins","year":"2003","journal-title":"Pharmacol Ther"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.4049\/jimmunol.0901691","article-title":"Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus","volume":"183","author":"Yamagami","year":"2009","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1172\/JCI24185","article-title":"Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display","volume":"115","author":"Payne","year":"2005","journal-title":"J Clin Invest"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/jid.2012.46","article-title":"Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris","volume":"132","author":"Sarig","year":"2012","journal-title":"J Invest Dermatol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1468-3083.2009.03260.x","article-title":"TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population","volume":"24","author":"Javor","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.humimm.2012.02.001","article-title":"Tumor necrosis factor-\u03b1\u2212308 GA and interleukin-6\u2212174 GC promoter polymorphisms and pemphigus","volume":"73","author":"Mosaad","year":"2012","journal-title":"Hum Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00403-004-0528-6","article-title":"Cytokine polymorphisms in patients with pemphigus","volume":"296","author":"Eberhard","year":"2005","journal-title":"Arch Dermatol Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.humimm.2005.11.004","article-title":"Pemphigus vulgaris is associated with the transporter associated with antigen processing (TAP) system","volume":"66","author":"Slomov","year":"2005","journal-title":"Hum Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.clindermatol.2016.05.021","article-title":"Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms","volume":"35","author":"Tanasilovic","year":"2017","journal-title":"Clin Dermatol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-2133.2005.06882.x","article-title":"Evidence of an association between desmoglein 3 haplotypes and pemphigus vulgaris","volume":"154","author":"Capon","year":"2006","journal-title":"Br J Dermatol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"19679","DOI":"10.1111\/bjd.19679","article-title":"ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumor necrosis factor-\u03b1-dependent fashion","volume":"2020","author":"Assaf","year":"2020","journal-title":"Br J Dermatol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"770","DOI":"10.3389\/fimmu.2019.00770","article-title":"ST18 enhances PV-IgG-induced loss of keratinocyte cohesion in parallel to increased ERK activation","volume":"10","author":"Radeva","year":"2019","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e212","DOI":"10.1111\/bjd.16022","article-title":"HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus","volume":"178","author":"Sena Nogueira Maehara","year":"2018","journal-title":"Br J Dermatol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1046\/j.1523-1747.1999.00626.x","article-title":"Common human leukocyte antigen alleles in pemphigus vulgaris and pemphigus foliaceus Italian patients","volume":"113","author":"Lombardi","year":"1999","journal-title":"J Invest Dermatol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1006\/jaut.2000.0388","article-title":"HLA class II polymorphism contributes to specify desmoglein derived peptides in pemphigus vulgaris and pemphigus foliaceus","volume":"15","author":"Loiseau","year":"2000","journal-title":"J Autoimmun"},{"key":"B44","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1365-4632.2005.02038.x","article-title":"HLA-DRB1*0101 is associated with foliaceous pemphigus in Mexicans","volume":"44","author":"del Mar S\u00e1ez-de-Ocariz","year":"2005","journal-title":"Int J Dermatol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/j.1365-2133.2009.09207.x","article-title":"Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles","volume":"161","author":"Abida","year":"2009","journal-title":"Br J Dermatol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.imlet.2017.02.005","article-title":"Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus","volume":"184","author":"Ben Jmaa","year":"2017","journal-title":"Immunol Lett"},{"key":"B47","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1590\/abd1806-4841.20188235","article-title":"Fogo selvagem: endemic pemphigus foliaceus","volume":"93","author":"Hans-Filho","year":"2018","journal-title":"An Bras Dermatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0190-9622(89)70079-7","article-title":"Endemic pemphigus foliaceus (fogo selvagem). I Clinical features and immunopathology","volume":"20","author":"Diaz","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1365-2133.2006.07302.x","article-title":"Clinical and serological follow-up studies of endemic pemphigus foliaceus (fogo selvagem) in Western Parana, Brazil (2001-2002)","volume":"155","author":"Empinotti","year":"2006","journal-title":"Br J Dermatol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/1346-8138.12675","article-title":"Update on fogo selvagem, an endemic form of pemphigus foliaceus","volume":"42","author":"Aoki","year":"2015","journal-title":"J Dermatol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/j.0022-202X.2004.23438.x","article-title":"Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas disease suggest a possible etiological link to Fogo selvagem","volume":"123","author":"Diaz","year":"2004","journal-title":"J Invest Dermatol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jaut.2008.08.003","article-title":"Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity","volume":"31","author":"Culton","year":"2008","journal-title":"J Autoimmun"},{"key":"B53","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/1523-1747.ep12612836","article-title":"Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women","volume":"104","author":"Bastuji-Garin","year":"1995","journal-title":"J Invest Dermatol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/j.1365-2133.1988.tb02590.x","article-title":"South American pemphigus foliaceus: study of an epidemic in El Bagre and Nechi, Colombia 1982 to 1986","volume":"118","author":"Robledo","year":"1988","journal-title":"Br J Dermatol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/j.1610-0387.2011.07793.x","article-title":"Autoimmune bullous skin diseases. Part 1: clinical manifestations","volume":"9","author":"Kneisel","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1167\/iovs.16-19582","article-title":"Pemphigus autoantibodies induce blistering in human conjunctiva","volume":"57","author":"Vielmuth","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/ddg.40_12612","article-title":"S2k-Leitlinie zur Diagnostik des Pemphigus vulgaris\/foliaceus und des bull\u00f6sen Pemphigoids","volume":"13","author":"Schmidt","year":"2015","journal-title":"J Deutschen Dermatologischen Gesellschaft"},{"key":"B58","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.clindermatol.2011.01.013","article-title":"Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis)","volume":"29","author":"Joly","year":"2011","journal-title":"Clin Dermatol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1002\/med.21310","article-title":"Desmosomes and extradesmosomal adhesive signaling contacts in pemphigus","volume":"34","author":"Waschke","year":"2014","journal-title":"Med Res Rev"},{"key":"B60","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1468-3083.2007.02298.x","article-title":"Pemphigus foliaceus evolving into pemphigus vulgaris: a probable example of \u2018intermolecular epitope spreading\u2019 confirmed by enzyme-linked immunosorbent assay study","volume":"22","author":"Pigozzi","year":"2008","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/j.1610-0387.2011.07809.x","article-title":"Autoimmune bullous skin diseases. Part 2: diagnosis and therapy","volume":"9","author":"Kneisel","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.2353\/ajpath.2010.100483","article-title":"Autoimmunity to desmocollin 3 in pemphigus vulgaris","volume":"177","author":"Mao","year":"2010","journal-title":"Am J Pathol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.ajpath.2010.10.016","article-title":"IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion","volume":"178","author":"Rafei","year":"2011","journal-title":"Am J Pathol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"30556","DOI":"10.1074\/jbc.M109.024810","article-title":"Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus","volume":"284","author":"Spindler","year":"2009","journal-title":"J Biol Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1111\/j.1365-2230.2009.03241.x","article-title":"Autoantibodies against desmocollins in European patients with pemphigus","volume":"34","author":"M\u00fcller","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1111\/bjd.18382","article-title":"The involvement of ADAM10 in acantholysis in mucocutaneous pemphigus vulgaris depends on the autoantibody profile of each patient","volume":"182","author":"Ivars","year":"2020","journal-title":"Br J Dermatol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/bjd.12940","article-title":"The expanding spectrum of IgA pemphigus: a case report and review of the literature","volume":"171","author":"Geller","year":"2014","journal-title":"Br J Dermatol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/archderm.135.2.143","article-title":"Desmoglein 3-ELISA: a pemphigus vulgaris-specific diagnostic tool","volume":"135","author":"Lenz","year":"1999","journal-title":"Arch Dermatol"},{"key":"B69","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.159.4.2010","article-title":"Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins","volume":"159","author":"Ishii","year":"1997","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev-pathol-012615-044313","article-title":"Mechanisms of disease: pemphigus and bullous pemphigoid","volume":"11","author":"Hammers","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0190-9622(96)80066-1","article-title":"Influence of treatment on the clinical course of pemphigus vulgaris","volume":"34","author":"Carson","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s00105-015-3656-3","article-title":"Pemphigus","volume":"66","author":"Eming","year":"2015","journal-title":"Modellerkrankung f\u00fcr zielgerichtete Therapien Hautarzt"},{"key":"B73","first-page":"1","article-title":"Updates on the management of autoimmune blistering diseases","volume":"19","author":"Hooten","year":"2014","journal-title":"Skin Therapy Lett"},{"key":"B74","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1046\/j.1365-2133.2003.05209_10.x","article-title":"Treatment of pemphigus vulgaris with anti-CD20 monoclonal antibody (rituximab)","volume":"148","author":"Herrmann","year":"2003","journal-title":"Br J Dermatol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"321950","DOI":"10.1155\/2010\/321950","article-title":"Targeted immunotherapy with rituximab leads to a transient alteration of the IgG autoantibody profile in pemphigus vulgaris","volume":"2010","author":"M\u00fcller","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"B76","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S1473-0502(02)00095-2","article-title":"Plasmapheresis therapy in pemphigus vulgaris and bullous pemphigoid","volume":"28","author":"Mazzi","year":"2003","journal-title":"Transfus Apher Sci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.jaci.2012.03.022","article-title":"Inhibitory human antichimeric antibodies to rituximab in a patient with pemphigus","volume":"130","author":"Lunardon","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/ddg.140_12606","article-title":"S2k-Leitlinie zur Therapie des Pemphigus vulgaris\/foliaceus und des bull\u00f6sen Pemphigoid","volume":"13","author":"Eming","year":"2015","journal-title":"J Deutschen Dermatologischen Gesellschaft"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0002-9440(10)61239-4","article-title":"Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus","volume":"167","author":"Arredondo","year":"2005","journal-title":"Am J Pathol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/jid.2010.111","article-title":"From cell signaling to novel therapeutic concepts: international pemphigus meeting on advances in pemphigus research and therapy","volume":"130","author":"Getsios","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1365-2230.2006.02220.x","article-title":"Improved protocol for treatment of pemphigus vulgaris with protein A immunoadsorption","volume":"31","author":"Shimanovich","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1046\/j.1365-2133.2003.05302.x","article-title":"Protein A immunoadsorption: a novel and effective adjuvant treatment of severe pemphigus","volume":"148","author":"Schmidt","year":"2003","journal-title":"Br J Dermatol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1468-3083.2006.01540.x","article-title":"The role of IVIg treatment in severe pemphigus vulgaris","volume":"20","author":"Baum","year":"2006","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/ncpneuro0856","article-title":"Erratum: shortage of human intravenous immunoglobulin\u2014reasons and possible solutions","volume":"4","author":"Bayry","year":"2008","journal-title":"Nat Rev Neurol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1080\/14712598.2021.1874915","article-title":"The evolving role of rituximab in the treatment of pemphigus vulgaris: a comprehensive state-of-the-art review","volume":"21","author":"Kridin","year":"2021","journal-title":"Expert Opin Biol Ther"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.01.031","article-title":"Rituximab and corticosteroid effect on desmoglein-specific B-cells and desmoglein-specific T-follicular-helper-cells in pemphigus","author":"Maho-Vaillant","year":"2021","journal-title":"J Invest Dermatol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s13317-017-0100-y","article-title":"Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment","volume":"8","author":"Du","year":"2017","journal-title":"Auto Immun Highlights"},{"key":"B88","first-page":"1338","article-title":"Successful treatment of pemphigus vulgaris with ofatumumab","volume":"17","author":"Rapp","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1093\/rheumatology\/kex067","article-title":"Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples","volume":"56","author":"Reddy","year":"2017","journal-title":"Rheumatology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/1744666X.2017.1291343","article-title":"Inhibition of B cell activating factor (BAFF) in the management of systemic lupus erythematosus (SLE)","volume":"13","author":"Stohl","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3389\/fimmu.2018.00622","article-title":"B cell modulation strategies in autoimmune diseases: new concepts","volume":"9","author":"Musette","year":"2018","journal-title":"Front Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B93","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1586\/1744666X.2016.1152888","article-title":"The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy","volume":"12","author":"Crofford","year":"2016","journal-title":"Expert Rev Clin Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/82_2015_478","article-title":"BTK signaling in B cell differentiation and autoimmunity","volume":"393","author":"Corneth","year":"2016","journal-title":"Curr Top Microbiol Immunol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/exd.12229","article-title":"Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris","volume":"22","author":"Amber","year":"2013","journal-title":"Exp Dermatol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.4049\/jimmunol.1401081","article-title":"Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB1*04:02-restricted T cells","volume":"193","author":"Eming","year":"2014","journal-title":"J Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.clim.2009.11.006","article-title":"Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3","volume":"134","author":"Nagel","year":"2010","journal-title":"Clin Immunol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1111\/ijd.14142","article-title":"Pemphigus foliaceus associated with imatinib therapy in a patient with gastrointestinal stromal tumor","volume":"57","author":"Chen","year":"2018","journal-title":"Int J Dermatol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4103\/idoj.IDOJ_331_17","article-title":"Imatinib-induced IgA pemphigus: subcorneal pustular dermatosis type","volume":"9","author":"Sood","year":"2018","journal-title":"Indian Dermatol Online J"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-12232-3","article-title":"Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model","volume":"10","author":"Ono","year":"2019","journal-title":"Nat Commun"},{"key":"B101","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.tips.2018.07.007","article-title":"Targeting FcRn to generate antibody-based therapeutics","volume":"39","author":"Ward","year":"2018","journal-title":"Trends Pharmacol Sci"},{"key":"B102","doi-asserted-by":"publisher","first-page":"5490","DOI":"10.1091\/mbc.e07-02-0101","article-title":"Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells","volume":"19","author":"Goebl","year":"2008","journal-title":"Mol Biol Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s00018-010-0318-6","article-title":"The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases","volume":"67","author":"Sesarman","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"B104","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/intimm\/dxr020","article-title":"Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris","volume":"23","author":"Yokoyama","year":"2011","journal-title":"Int Immunol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s40265-018-0976-5","article-title":"Targeted therapies for autoimmune bullous diseases: current status","volume":"78","author":"Amber","year":"2018","journal-title":"Drugs"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e41769","DOI":"10.1371\/journal.pone.0041769","article-title":"Pathogenicity of autoantibodies in anti-p200 pemphigoid","volume":"7","author":"Vafia","year":"2012","journal-title":"PLoS ONE"},{"key":"B107","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1073\/pnas.90.2.720","article-title":"Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors","volume":"90","author":"Eshhar","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B108","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2217\/imt-2017-0028","article-title":"Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities","volume":"9","author":"Wegner","year":"2017","journal-title":"Immunotherapy"},{"key":"B109","doi-asserted-by":"publisher","first-page":"e57587","DOI":"10.1371\/journal.pone.0057587","article-title":"Pemphigus vulgaris autoantibody profiling by proteomic technique","volume":"8","author":"Kalantari-Dehaghi","year":"2013","journal-title":"PLoS ONE"},{"key":"B110","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1046\/j.0022-202x.2001.01489.x","article-title":"Pemphigus: an unfolding story","volume":"117","author":"Grando","year":"2001","journal-title":"J Investig Dermatol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1365-2230.2011.04092.x","article-title":"The pathogenic role of autoantibodies in pemphigus vulgaris","volume":"36","author":"Pan","year":"2011","journal-title":"Clin Exp Dermatol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J Immunol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jdermsci.2016.12.010","article-title":"Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering","volume":"85","author":"Yoshida","year":"2017","journal-title":"J Dermatol Sci"},{"key":"B114","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00281-015-0541-1","article-title":"Immune response in pemphigus and beyond: progresses and emerging concepts","volume":"38","author":"Di Zenzo","year":"2016","journal-title":"Semin Immunopathol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/j.1365-2133.2009.09386.x","article-title":"The familial feature of Tunisian endemic pemphigus foliaceus","volume":"161","author":"Abida","year":"2009","journal-title":"Br J Dermatol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1046\/j.1365-2133.1999.02605.x","article-title":"Immunoblot and immunoelectronmicroscopic analysis of endemic Tunisian pemphigus","volume":"140","author":"Joly","year":"1999","journal-title":"Br J Dermatol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1365-2249.2004.02493.x","article-title":"Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus","volume":"137","author":"Kallel Sellami","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.4049\/jimmunol.182.3.1740","article-title":"A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris","volume":"182","author":"Takahashi","year":"2009","journal-title":"J Immunol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1083\/jcb.137.5.1091","article-title":"Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris","volume":"137","author":"Koch","year":"1997","journal-title":"J Cell Biol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI8748","article-title":"Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus","volume":"105","author":"Amagai","year":"2000","journal-title":"J Clin Invest"},{"key":"B121","doi-asserted-by":"publisher","first-page":"50024","DOI":"10.1371\/journal.pone.0050024","article-title":"Unimpaired skin carcinogenesis in desmoglein 3 knockout mice","volume":"7","author":"Baron","year":"2012","journal-title":"PLoS ONE"},{"key":"B122","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1242\/jcs.031518","article-title":"Loss of desmocollin 3 in mice leads to epidermal blistering","volume":"121","author":"Chen","year":"2008","journal-title":"J Cell Sci"},{"key":"B123","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/1346-8138.13086","article-title":"Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3","volume":"43","author":"Kamiya","year":"2016","journal-title":"J Dermatol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3389\/fimmu.2019.01387","article-title":"Development of a desmocollin-3 active mouse model recapitulating human atypical pemphigus","volume":"10","author":"Lotti","year":"2019","journal-title":"Front Immunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.jid.2019.01.002","article-title":"Desmoglein 1 deficiency causes lethal skin blistering","volume":"139","author":"Kugelmann","year":"2019","journal-title":"J Invest Dermatol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"7623","DOI":"10.1074\/jbc.M512447200","article-title":"Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies","volume":"281","author":"Calkins","year":"2006","journal-title":"J Biol Chem"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1016\/j.ajpath.2011.06.043","article-title":"The extent of desmoglein 3 depletion in pemphigus vulgaris is dependent on Ca2+-induced differentiation","volume":"179","author":"Spindler","year":"2011","journal-title":"Am J Pathol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00403-007-0754-9","article-title":"Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis","volume":"299","author":"Shu","year":"2007","journal-title":"Arch Dermatol Res"},{"key":"B129","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/jid.2010.389","article-title":"Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3","volume":"131","author":"Jennings","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"17866","DOI":"10.1074\/jbc.M607963200","article-title":"Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity","volume":"282","author":"Yamamoto","year":"2007","journal-title":"J Biol Chem"},{"key":"B131","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1523-1747.1999.00463.x","article-title":"Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells","volume":"112","author":"Aoyama","year":"1999","journal-title":"J Invest Dermatol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"8936","DOI":"10.1074\/jbc.M109.087999","article-title":"p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis","volume":"285","author":"Jolly","year":"2010","journal-title":"J Biol Chem"},{"key":"B133","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/229059a0","article-title":"Ultrastructural localization of pemphigus autoantibodies within e epidermis","volume":"229","author":"Wolff","year":"1971","journal-title":"Nature"},{"key":"B134","doi-asserted-by":"publisher","first-page":"7282","DOI":"10.1073\/pnas.83.19.7282","article-title":"A cell surface desmosome-associated component: identification of tissue-specific cell adhesion molecule","volume":"83","author":"Jones","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/labinvest.3780168","article-title":"Assembly pathway of desmoglein 3 to desmosomes and its perturbation by pemphigus vulgaris-IgG in cultured keratinocytes, as revealed by time-lapsed labeling immunoelectron microscopy","volume":"80","author":"Sato","year":"2000","journal-title":"Lab Invest"},{"key":"B136","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/BF02507101","article-title":"Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris: comparison of 14 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus studied by western immunoblot and immunoelectron microscopy","volume":"288","author":"B\u00e9dane","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"B137","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1038\/jid.2015.324","article-title":"Loss of desmoglein binding is not sufficient for keratinocyte dissociation in pemphigus","volume":"135","author":"Vielmuth","year":"2015","journal-title":"J Invest Dermatol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/path.3982","article-title":"Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris","volume":"227","author":"Tsang","year":"2012","journal-title":"J Pathol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/jid.2008.339","article-title":"Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies","volume":"129","author":"Mao","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/1523-1747.ep12274679","article-title":"Experimentally induced pemphigus vulgaris in neonatal BALB\/c mice: a time-course study of clinical, immunologic, ultrastructural, and cytochemical changes","volume":"84","author":"Takahashi","year":"1985","journal-title":"J Investig Dermatol"},{"key":"B141","first-page":"345","article-title":"Epidermal acantholysis induced in vitro by pemphigus autoantibody. An ultrastructural study","volume":"90","author":"Hu","year":"1978","journal-title":"Am J Pathol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1365-2133.2008.08971.x","article-title":"The ultrastructure of acantholysis in pemphigus vulgaris","volume":"160","author":"Diercks","year":"2009","journal-title":"Br J Dermatol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.jaad.2005.12.003","article-title":"A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis","volume":"54","author":"Bystryn","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/15419061.2013.877000","article-title":"Desmosomal cadherins and signaling: lessons from autoimmune disease","volume":"21","author":"Spindler","year":"2014","journal-title":"Cell Commun Adhes"},{"key":"B145","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/jid.1961.58","article-title":"An electron microscopic study of acantholysis in pemphigus vulgaris","volume":"36","author":"Wilgram","year":"1961","journal-title":"J Invest Dermatol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1016\/j.febslet.2006.04.089","article-title":"Serum from pemphigus vulgaris reduces desmoglein 3 half-life and perturbs its de novo assembly to desmosomal sites in cultured keratinocytes","volume":"580","author":"Cirillo","year":"2006","journal-title":"FEBS Lett"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1242\/jcs.115.8.1717","article-title":"Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover","volume":"115","author":"Windoffer","year":"2002","journal-title":"J Cell Sci"},{"key":"B148","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00441-003-0812-3","article-title":"Continual assembly of desmosomes within stable intercellular contacts of epithelial A-431 cells","volume":"314","author":"Gloushankova","year":"2003","journal-title":"Cell Tissue Res"},{"key":"B149","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1365-2133.2011.10463.x","article-title":"IgG-induced clustering of desmogleins 1 and 3 in skin of patients with pemphigus fits with the desmoglein non-assembly depletion hypothesis","volume":"165","author":"Oktarina","year":"2011","journal-title":"Br J Dermatol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fimmu.2018.00136","article-title":"Pemphigus-a disease of desmosome dysfunction caused by multiple mechanisms","volume":"9","author":"Spindler","year":"2018","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3389\/fimmu.2018.00528","article-title":"Keratins regulate p38MAPK-dependent desmoglein binding properties in pemphigus","volume":"9","author":"Vielmuth","year":"2018","journal-title":"Front Immunol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1038\/s41598-017-03697-7","article-title":"Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus","volume":"7","author":"Walter","year":"2017","journal-title":"Sci Rep"},{"key":"B153","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3389\/fimmu.2018.00858","article-title":"Keratin retraction and desmoglein3 internalization independently contribute to autoantibody-induced cell dissociation in pemphigus vulgaris","volume":"9","author":"Schl\u00f6gl","year":"2018","journal-title":"Front Immunol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.autrev.2009.01.011","article-title":"Apoptosis in pemphigus","volume":"8","author":"Schmidt","year":"2009","journal-title":"Autoimmun Rev"},{"key":"B155","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00428-007-0410-y","article-title":"Dell'Ermo A, Arnese P, Gombos F, Lanza A. A novel method to investigate pemphigus-induced keratinocyte dysmorphisms through living cell immunofluorescence microscopy","volume":"450","author":"Cirillo","year":"2007","journal-title":"Virchows Arch"},{"key":"B156","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/1523-1747.ep12319948","article-title":"Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line","volume":"105","author":"Esaki","year":"1995","journal-title":"J Invest Dermatol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"C606","DOI":"10.1152\/ajpcell.00075.2010","article-title":"Actin reorganization contributes to loss of cell adhesion in pemphigus vulgaris","volume":"299","author":"Gliem","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jid.2017.06.022","article-title":"Mechanisms causing loss of keratinocyte cohesion in pemphigus","volume":"138","author":"Spindler","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B159","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"B160","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/1523-1747.ep12613469","article-title":"Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line","volume":"104","author":"Seishima","year":"1995","journal-title":"J Invest Dermatol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/fimmu.2018.00485","article-title":"Atomic force microscopy provides new mechanistic insights into the pathogenesis of pemphigus","volume":"9","author":"Vielmuth","year":"2018","journal-title":"Front Immunol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.4049\/jimmunol.167.9.5439","article-title":"Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins","volume":"167","author":"Sekiguchi","year":"2001","journal-title":"J Immunol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"8064","DOI":"10.1073\/pnas.95.14.8064","article-title":"Desmosomal adhesion inhibits invasive behavior","volume":"95","author":"Tselepis","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"B164","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/ncb0901-823","article-title":"Desmosomal adhesion regulates epithelial morphogenesis and cell positioning","volume":"3","author":"Runswick","year":"2001","journal-title":"Nat Cell Biol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/j.0022-202X.2004.22426.x","article-title":"IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model","volume":"122","author":"Shimizu","year":"2004","journal-title":"J Investig Dermatol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/1523-1747.ep12316695","article-title":"Pemphigus vulgaris and pemphigus foliaceus sera show an inversely graded binding pattern to extracellular regions of desmosomes in different layers of human epidermis","volume":"105","author":"Shimizu","year":"1995","journal-title":"J Investig Dermatol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.nano.2014.10.006","article-title":"Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes","volume":"11","author":"Vielmuth","year":"2015","journal-title":"Nanomedicine"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.4049\/jimmunol.181.3.1825","article-title":"Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction","volume":"181","author":"Heupel","year":"2008","journal-title":"J Immunol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.010","article-title":"Pemphigus vulgaris and foliaceus IgG autoantibodies directly block heterophilic trans-interaction between desmoglein and desmocollin","author":"Ishii","year":"2020","journal-title":"J Invest Dermatol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jid.2017.08.033","article-title":"Keratins regulate the adhesive properties of desmosomal cadherins through signaling","volume":"138","author":"Vielmuth","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1172\/JCI23475","article-title":"Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction","volume":"115","author":"Waschke","year":"2005","journal-title":"J Clin Invest"},{"key":"B172","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1365-2133.2004.06147.x","article-title":"In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades","volume":"151","author":"S\u00e1nchez-Carpintero","year":"2004","journal-title":"Br J Dermatol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.jid.2017.01.028","article-title":"Meeting report of the pathogenesis of pemphigus and pemphigoid meeting in Munich, September 2016","volume":"137","author":"Schmidt","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-195302000-00001","article-title":"Pemphigus","volume":"32","author":"Lever","year":"1953","journal-title":"Medicine"},{"key":"B175","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/cup.12384","article-title":"Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus","volume":"41","author":"Ohata","year":"2014","journal-title":"J Cutan Pathol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1001\/jama.282.6.572","article-title":"Pemphigus\u2013diseases of antidesmosomal autoimmunity","volume":"282","author":"Udey","year":"1999","journal-title":"JAMA"},{"key":"B177","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1038\/jid.2014.60","article-title":"No evidence of apoptotic cells in pemphigus acantholysis","volume":"134","author":"Janse","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1038\/jid.2015.109","article-title":"Large-scale electron microscopy maps of patient skin and mucosa provide insight into pathogenesis of blistering diseases","volume":"135","author":"Sokol","year":"2015","journal-title":"J Invest Dermatol"},{"key":"B179","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/jid.2014.140","article-title":"Smaller desmosomes are seen in the skin of pemphigus patients with anti-desmoglein 1 antibodies but not in patients with anti-desmoglein 3 antibodies","volume":"134","author":"van","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/jid.1964.159","article-title":"An electron microscopic study of acantholysis and dyskeratosis in pemphigus foliaceus. With a special note on peculiar intracytoplasmic bodies","volume":"43","author":"Wilgram","year":"1964","journal-title":"J Investig Dermatol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/JID.2015.353","article-title":"Super-resolution microscopy reveals altered desmosomal protein organization in tissue from patients with pemphigus vulgaris","volume":"136","author":"Stahley","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1111\/bjd.15721","article-title":"Inhibition of p38MAPK signalling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis","volume":"177","author":"Egu","year":"2017","journal-title":"Br J Dermatol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"943397","DOI":"10.3109\/15419061.2014.943397","article-title":"150(th) anniversary series: desmosomes and autoimmune disease, perspective of dynamic desmosome remodeling and its impairments in pemphigus","volume":"21","author":"Kitajima","year":"2014","journal-title":"Cell Commun Adhes"},{"key":"B184","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tcb.2013.06.004","article-title":"Desmosome assembly and dynamics","volume":"23","author":"Nekrasova","year":"2013","journal-title":"Trends Cell Biol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"e87809","DOI":"10.1371\/journal.pone.0087809","article-title":"Desmosome assembly and disassembly are membrane raft-dependent","volume":"9","author":"Stahley","year":"2014","journal-title":"PLoS ONE"},{"key":"B186","doi-asserted-by":"publisher","first-page":"28820","DOI":"10.1038\/srep28820","article-title":"Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes","volume":"6","author":"V\u00f6llner","year":"2016","journal-title":"Sci Rep"},{"key":"B187","doi-asserted-by":"publisher","first-page":"4885","DOI":"10.1007\/s00018-015-1977-0","article-title":"E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion","volume":"72","author":"R\u00f6tzer","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"B188","doi-asserted-by":"publisher","first-page":"37629","DOI":"10.7554\/eLife.37629","article-title":"E-cadherin binds to desmoglein to facilitate desmosome assembly","volume":"7","author":"Shafraz","year":"2018","journal-title":"Elife"},{"key":"B189","doi-asserted-by":"publisher","first-page":"jcb","DOI":"10.1083\/jcb.200712133","article-title":"Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly","volume":"181","author":"Bass-Zubek","year":"2008","journal-title":"J Cell Biol"},{"key":"B190","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1091\/mbc.e10-02-0131","article-title":"Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA","volume":"21","author":"Godsel","year":"2010","journal-title":"Mol Biol Cell"},{"key":"B191","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3389\/fimmu.2019.00626","article-title":"Role of Src and cortactin in pemphigus skin blistering","volume":"10","author":"Kugelmann","year":"2019","journal-title":"Front Immunol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"14925","DOI":"10.1074\/jbc.M113.527127","article-title":"Adducin is required for desmosomal cohesion in keratinocytes","volume":"289","author":"R\u00f6tzer","year":"2014","journal-title":"J Biol Chem"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1101\/787846","article-title":"The actin-binding protein \u03b1-adducin modulates desmosomal turnover and plasticity","author":"Hiermaier","year":"2020","journal-title":"J Invest Dermatol"},{"key":"B194","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.1091\/mbc.e14-05-0968","article-title":"Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation","volume":"25","author":"Todorovic","year":"2014","journal-title":"Mol Biol Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1074\/jbc.M110.192245","article-title":"Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells","volume":"286","author":"Nie","year":"2011","journal-title":"J Biol Chem"},{"key":"B196","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1083\/jcb.201906153","article-title":"Protein exchange is reduced in calcium-independent epithelial junctions","volume":"219","author":"Bartle","year":"2020","journal-title":"J Cell Biol"},{"key":"B197","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/jid.2011.318","article-title":"Desmoplakin regulates desmosome hyperadhesion","volume":"132","author":"Hobbs","year":"2012","journal-title":"J Invest Dermatol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1042\/BST0360195","article-title":"Hyper-adhesion: a new concept in cell-cell adhesion","volume":"36","author":"Garrod","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"B199","doi-asserted-by":"publisher","first-page":"212439","DOI":"10.1155\/2010\/212439","article-title":"Desmosomes in vivo","volume":"2010","author":"Garrod","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1091\/mbc.11.3.1077","article-title":"The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells","volume":"11","author":"Wallis","year":"2000","journal-title":"Mol Biol Cell"},{"key":"B201","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.jid.5700643","article-title":"Calcium-independent desmosomes of keratinocytes are hyper-adhesive","volume":"127","author":"Kimura","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B202","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.yexcr.2009.10.005","article-title":"Induction of hyper-adhesion attenuates autoimmune-induced keratinocyte cell-cell detachment and processing of adhesion molecules via mechanisms that involve PKC","volume":"316","author":"Cirillo","year":"2010","journal-title":"Exp Cell Res"},{"key":"B203","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1007\/s00018-019-03083-8","article-title":"Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering","volume":"76","author":"Fuchs","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B204","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00232-007-9037-9","article-title":"Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction","volume":"216","author":"Waschke","year":"2007","journal-title":"J Membr Biol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"5743","DOI":"10.1242\/jcs.02700","article-title":"Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure","volume":"118","author":"Garrod","year":"2005","journal-title":"J Cell Sci"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.bpj.2020.09.008","article-title":"Desmosomal hyperadhesion is accompanied with enhanced binding strength of desmoglein 3 molecules","volume":"119","author":"Fuchs","year":"2020","journal-title":"Biophys J"},{"key":"B207","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/jid.2013.401","article-title":"Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes","volume":"134","author":"Tucker","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B208","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1016\/j.ajpath.2014.05.016","article-title":"A desmoplakin point mutation with enhanced keratin association ameliorates pemphigus vulgaris autoantibody-mediated loss of cell cohesion","volume":"184","author":"Dehner","year":"2014","journal-title":"Am J Pathol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1083\/jcb.201208162","article-title":"Keratins control intercellular adhesion involving PKC-\u03b1-mediated desmoplakin phosphorylation","volume":"201","author":"Kr\u00f6ger","year":"2013","journal-title":"J Cell Biol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1161\/CIRCRESAHA.116.309631","article-title":"Adrenergic signaling strengthens cardiac myocyte cohesion","volume":"120","author":"Schinner","year":"2017","journal-title":"Circ Res"},{"key":"B211","doi-asserted-by":"publisher","first-page":"e13242","DOI":"10.1111\/apha.13242","article-title":"Regulation of cardiac myocyte cohesion and gap junctions via desmosomal adhesion","volume":"226","author":"Schinner","year":"2019","journal-title":"Acta Physiol"},{"key":"B212","doi-asserted-by":"publisher","first-page":"140066","DOI":"10.1172\/jci.insight.140066","article-title":"Cardiomyocyte adhesion and hyperadhesion differentially require ERK1\/2 and plakoglobin","volume":"5","author":"Shoykhet","year":"2020","journal-title":"JCI Insight"},{"key":"B213","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.jid.2016.05.124","article-title":"Antagonistic regulation of intercellular cohesion by plakophilins 1 and 3","volume":"136","author":"Keil","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B214","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fphys.2020.00430","article-title":"Adrenergic signaling-induced ultrastructural strengthening of intercalated discs via plakoglobin is crucial for positive adhesiotropy in murine cardiomyocytes","volume":"11","author":"Yeruva","year":"2020","journal-title":"Front Physiol"},{"key":"B215","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.3389\/fimmu.2019.02883","article-title":"Role of PKC and ERK signaling in epidermal blistering and desmosome regulation in pemphigus","volume":"10","author":"Egu","year":"2019","journal-title":"Front Immunol"},{"key":"B216","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1172\/JCI60139","article-title":"Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering","volume":"123","author":"Spindler","year":"2013","journal-title":"J Clin Invest"},{"key":"B217","doi-asserted-by":"publisher","first-page":"8589","DOI":"10.1074\/jbc.M808813200","article-title":"Peptides targeting the desmoglein 3 adhesive interface prevent autoantibody-induced acantholysis in pemphigus","volume":"284","author":"Heupel","year":"2009","journal-title":"J Biol Chem"},{"key":"B218","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1038\/jid.2014.21","article-title":"Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling","volume":"134","author":"Spindler","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"e13609","DOI":"10.1111\/apha.13609","article-title":"Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion","volume":"231","author":"Wanuske","year":"2021","journal-title":"Acta Physiol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"bjd","DOI":"10.1111\/bjd.20091","article-title":"Ca2+ signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus","volume":"2021","author":"Schmitt","year":"2021","journal-title":"Br J Dermatol"},{"key":"B221","doi-asserted-by":"publisher","first-page":"17043","DOI":"10.1074\/jbc.M113.489336","article-title":"Desmoglein 2 compensates for desmoglein 3 but does not control cell adhesion via regulation of p38 mitogen-activated protein kinase in keratinocytes","volume":"289","author":"Hartlieb","year":"2014","journal-title":"J Biol Chem"},{"key":"B222","doi-asserted-by":"publisher","first-page":"6329","DOI":"10.1038\/s41598-017-06713-y","article-title":"Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase","volume":"7","author":"Ungewi\u00df","year":"2017","journal-title":"Sci Rep"},{"key":"B223","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1007\/s00018-018-2869-x","article-title":"Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion","volume":"75","author":"Ungewi\u00df","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"B224","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/JID.2015.380","article-title":"Desmoglein 3-dependent signaling regulates keratinocyte migration and wound healing","volume":"136","author":"R\u00f6tzer","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B225","doi-asserted-by":"publisher","first-page":"12855","DOI":"10.1073\/pnas.0602973103","article-title":"p38MAPK inhibition prevents disease in pemphigus vulgaris mice","volume":"103","author":"Berkowitz","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.2353\/ajpath.2008.080391","article-title":"Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin","volume":"173","author":"Berkowitz","year":"2008","journal-title":"Am J Pathol"},{"key":"B227","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1083\/jcb.200605125","article-title":"Inhibition of Rho A activity causes pemphigus skin blistering","volume":"175","author":"Waschke","year":"2006","journal-title":"J Cell Biol"},{"key":"B228","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3389\/fimmu.2019.01128","article-title":"Role of Dsg1- and Dsg3-mediated signaling in pemphigus autoantibody-induced loss of keratinocyte cohesion","volume":"10","author":"Walter","year":"2019","journal-title":"Front Immunol"},{"key":"B229","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1111\/bph.15233","article-title":"Identification of novel therapeutic targets for blocking acantholysis in pemphigus","volume":"177","author":"Burmester","year":"2020","journal-title":"Br J Pharmacol"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1083\/jcb.200809044","article-title":"Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis","volume":"185","author":"Getsios","year":"2009","journal-title":"J Cell Biol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/s41467-017-01170-7","article-title":"E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning","volume":"8","author":"R\u00fcbsam","year":"2017","journal-title":"Nat Commun"},{"key":"B232","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jid.2019.08.433","article-title":"The role of desmoglein 1 in gap junction turnover revealed through the study of SAM syndrome","volume":"140","author":"Cohen-Barak","year":"2020","journal-title":"J Invest Dermatol"},{"key":"B233","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1074\/jbc.M110.172874","article-title":"p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris","volume":"286","author":"Mao","year":"2011","journal-title":"J Biol Chem"},{"key":"B234","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1126\/science.7914033","article-title":"A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells","volume":"265","author":"Han","year":"1994","journal-title":"Science"},{"key":"B235","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1002\/j.1460-2075.1996.tb00840.x","article-title":"and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2","volume":"15","author":"Tan","year":"1996","journal-title":"EMBO J"},{"key":"B236","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1242\/jcs.110.3.357","article-title":"Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27","volume":"110","author":"Guay","year":"1997","journal-title":"J Cell Sci"},{"key":"B237","doi-asserted-by":"publisher","first-page":"23778","DOI":"10.1074\/jbc.M501365200","article-title":"Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization","volume":"280","author":"Berkowitz","year":"2005","journal-title":"J Biol Chem"},{"key":"B238","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/sj.jid.5701080","article-title":"Induction of p38MAPK and HSP27 phosphorylation in pemphigus patient skin","volume":"128","author":"Berkowitz","year":"2008","journal-title":"J Invest Dermatol"},{"key":"B239","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1042\/bj3180247","article-title":"Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists","volume":"318","author":"Nahas","year":"1996","journal-title":"Biochem J"},{"key":"B240","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1126\/science.272.5266.1347","article-title":"Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase","volume":"272","author":"Wang","year":"1996","journal-title":"Science"},{"key":"B241","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jid.2017.10.011","article-title":"Threonine 150 phosphorylation of keratin 5 is linked to epidermolysis bullosa simplex and regulates filament assembly and cell viability","volume":"138","author":"Sawant","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B242","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1172\/JCI120261","article-title":"Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease","volume":"129","author":"Meir","year":"2019","journal-title":"J Clin Invest"},{"key":"B243","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200703174","article-title":"p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells","volume":"177","author":"W\u00f6ll","year":"2007","journal-title":"J Cell Biol"},{"key":"B244","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/jid.2013.224","article-title":"kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris","volume":"134","author":"Mao","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B245","doi-asserted-by":"publisher","first-page":"L930","DOI":"10.1152\/ajplung.1997.273.5.L930","article-title":"Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle","volume":"273","author":"Larsen","year":"1997","journal-title":"Am J Physiol"},{"key":"B246","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1242\/jcs.112.13.2099","article-title":"Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin","volume":"112","author":"Perng","year":"1999","journal-title":"J Cell Sci"},{"key":"B247","doi-asserted-by":"publisher","first-page":"e50696","DOI":"10.1371\/journal.pone.0050696","article-title":"Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation","volume":"7","author":"Saito","year":"2012","journal-title":"PLoS ONE"},{"key":"B248","doi-asserted-by":"publisher","first-page":"12524","DOI":"10.1074\/jbc.M808204200","article-title":"Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis","volume":"284","author":"Lee","year":"2009","journal-title":"J Biol Chem"},{"key":"B249","doi-asserted-by":"publisher","first-page":"13804","DOI":"10.1074\/jbc.M611365200","article-title":"Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens","volume":"282","author":"Chernyavsky","year":"2007","journal-title":"J Biol Chem"},{"key":"B250","doi-asserted-by":"publisher","first-page":"906","DOI":"10.2353\/ajpath.2007.070028","article-title":"Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3","volume":"171","author":"Spindler","year":"2007","journal-title":"Am J Pathol"},{"key":"B251","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11010-017-3086-x","article-title":"Blocking RhoA\/ROCK inhibits the pathogenesis of pemphigus vulgaris by suppressing oxidative stress and apoptosis through TAK1\/NOD2-mediated NF-\u03baB pathway","volume":"436","author":"Liang","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"B252","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1098\/rstb.2000.0632","article-title":"Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton","volume":"355","author":"Hall","year":"2000","journal-title":"Philos Trans R Soc Lond B, Biol Sci"},{"key":"B253","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10059-010-0053-8","article-title":"Regulation of actin cytoskeleton dynamics in cells","volume":"29","author":"Lee","year":"2010","journal-title":"Mol Cells"},{"key":"B254","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrm2957","article-title":"Cell adhesion: integrating cytoskeletal dynamics and cellular tension","volume":"11","author":"Parsons","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B255","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.136.4.919","article-title":"Cross-talk between adherens junctions and desmosomes depends on plakoglobin","volume":"136","author":"Lewis","year":"1997","journal-title":"J Cell Biol"},{"key":"B256","doi-asserted-by":"publisher","first-page":"40355","DOI":"10.1074\/jbc.M506692200","article-title":"Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor","volume":"280","author":"Yin","year":"2005","journal-title":"J Biol Chem"},{"key":"B257","doi-asserted-by":"publisher","first-page":"6480","DOI":"10.1073\/pnas.1019469108","article-title":"The three-dimensional molecular structure of the desmosomal plaque","volume":"108","author":"Al-Amoudi","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B258","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1242\/jcs.111.4.495","article-title":"Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion","volume":"111","author":"Marcozzi","year":"1998","journal-title":"J Cell Sci"},{"key":"B259","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/cm.970320403","article-title":"Plakoglobin: kinetics of synthesis, phosphorylation, stability, and interactions with desmoglein and E-cadherin","volume":"32","author":"Pasdar","year":"1995","journal-title":"Cell Motil Cytoskeleton"},{"key":"B260","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1083\/jcb.153.4.823","article-title":"A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris","volume":"153","author":"Caldelari","year":"2001","journal-title":"J Cell Biol"},{"key":"B261","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/j.1600-0625.2007.00557.x","article-title":"Plakoglobin-dependent disruption of the desmosomal plaque in pemphigus vulgaris","volume":"16","author":"de Bruin","year":"2007","journal-title":"Exp Dermatol"},{"key":"B262","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1034\/j.1600-0560.2002.290906.x","article-title":"Strict correlation between uPAR and plakoglobin expression in pemphigus vulgaris","volume":"29","author":"Lo Muzio","year":"2002","journal-title":"J Cutan Pathol"},{"key":"B263","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1002\/(SICI)1521-4141(199907)29:07<2233::AID-IMMU2233>3.0.CO;2-4","article-title":"A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes","volume":"29","author":"Aoyama","year":"1999","journal-title":"Eur J Immunol"},{"key":"B264","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1038\/sj.emboj.7601224","article-title":"Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin","volume":"25","author":"Williamson","year":"2006","journal-title":"EMBO J"},{"key":"B265","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1038\/sj.jid.5700735","article-title":"Nuclear c-Myc: a molecular marker for early stage pemphigus vulgaris","volume":"127","author":"Williamson","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B266","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1600-0625.2009.00893.x","article-title":"An imbalance in Akt\/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris","volume":"18","author":"Pretel","year":"2009","journal-title":"Exp Dermatol"},{"key":"B267","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/j.yexcr.2012.07.002","article-title":"Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1\/Cdc42 in the regulation of actin organisation and dynamics","volume":"318","author":"Tsang","year":"2012","journal-title":"Exp Cell Res"},{"key":"B268","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3109\/08916934.2013.866100","article-title":"Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3","volume":"47","author":"Cirillo","year":"2014","journal-title":"Autoimmunity"},{"key":"B269","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1038\/msb4100014","article-title":"A comprehensive pathway map of epidermal growth factor receptor signaling","volume":"1","author":"Oda","year":"2005","journal-title":"Mol Syst Biol"},{"key":"B270","doi-asserted-by":"publisher","first-page":"8335","DOI":"10.1074\/jbc.274.12.8335","article-title":"c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function","volume":"274","author":"Biscardi","year":"1999","journal-title":"J Biol Chem"},{"key":"B271","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/exd.12290","article-title":"EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus vulgaris in a non-linear, V-shaped relationship","volume":"23","author":"Sayar","year":"2014","journal-title":"Exp Dermatol"},{"key":"B272","doi-asserted-by":"publisher","first-page":"9447","DOI":"10.1074\/jbc.M112.438010","article-title":"A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis","volume":"288","author":"Bektas","year":"2013","journal-title":"J Biol Chem"},{"key":"B273","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1080\/08916930600971836","article-title":"Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis\u2013possible involvement of the EGF receptor","volume":"39","author":"Frusi\u0107-Zlotkin","year":"2006","journal-title":"Autoimmunity"},{"key":"B274","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S0955-0674(99)80024-6","article-title":"Epidermal growth factor receptors: critical mediators of multiple receptor pathways","volume":"11","author":"Hackel","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"B275","doi-asserted-by":"publisher","first-page":"37191","DOI":"10.1074\/jbc.M405123200","article-title":"Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells","volume":"279","author":"Lorch","year":"2004","journal-title":"J Biol Chem"},{"key":"B276","doi-asserted-by":"publisher","first-page":"51110","DOI":"10.3390\/cells9051110","article-title":"Targeting GSK3 and associated signaling pathways involved in cancer","volume":"9","author":"Duda","year":"2020","journal-title":"Cells"},{"key":"B277","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1517\/14728222.2011.541440","article-title":"EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy","volume":"15","author":"Freudlsperger","year":"2011","journal-title":"Expert Opin Ther Targets"},{"key":"B278","doi-asserted-by":"publisher","first-page":"19361","DOI":"10.3390\/ijms141019361","article-title":"EGFR-Ras-Raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers","volume":"14","author":"Doma","year":"2013","journal-title":"Int J Mol Sci"},{"key":"B279","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1158\/1541-7786.MCR-18-0048","article-title":"Desmoglein 1 regulates invadopodia by suppressing EGFR\/Erk signaling in an erbin-dependent manner","volume":"17","author":"Valenzuela-Iglesias","year":"2019","journal-title":"Mol Cancer Res"},{"key":"B280","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1172\/JCI69071","article-title":"Desmoglein-1, differentiation, and disease","volume":"123","author":"Hammers","year":"2013","journal-title":"J Clin Invest"},{"key":"B281","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1172\/JCI65220","article-title":"Desmoglein-1\/Erbin interaction suppresses ERK activation to support epidermal differentiation","volume":"123","author":"Harmon","year":"2013","journal-title":"J Clin Invest"},{"key":"B282","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S1534-5807(03)00159-X","article-title":"c-Jun is essential for organization of the epidermal leading edge","volume":"4","author":"Li","year":"2003","journal-title":"Dev Cell"},{"key":"B283","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1128\/MCB.18.2.1065","article-title":"Epidermal growth factor induction of the c-jun promoter by a Rac pathway","volume":"18","author":"Clarke","year":"1998","journal-title":"Mol Cell Biol"},{"key":"B284","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.3389\/fimmu.2019.01454","article-title":"Proteases in pemphigoid diseases","volume":"10","author":"Hiroyasu","year":"2019","journal-title":"Front Immunol"},{"key":"B285","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0923-1811(92)90065-J","article-title":"Decompensation in proteinase-inhibitor system and application of proteinase inhibitors in pemphigus and pemphigoid","volume":"4","author":"Grando","year":"1992","journal-title":"J Dermatol Sci"},{"key":"B286","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/jcp.20997","article-title":"Defining the involvement of proteinases in pemphigus vulgaris: evidence of matrix metalloproteinase-9 overexpression in experimental models of disease","volume":"212","author":"Cirillo","year":"2007","journal-title":"J Cell Physiol"},{"key":"B287","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/bs.ctdb.2014.11.027","article-title":"Cell adhesion in epidermal development and barrier formation","volume":"112","author":"Sumigray","year":"2015","journal-title":"Curr Top Dev Biol"},{"key":"B288","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nature22366","article-title":"Architecture of the human interactome defines protein communities and disease networks","volume":"545","author":"Huttlin","year":"2017","journal-title":"Nature"},{"key":"B289","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"B290","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1152\/physrev.00028.2012","article-title":"Phosphoinositides: tiny lipids with giant impact on cell regulation","volume":"93","author":"Balla","year":"2013","journal-title":"Physiol Rev"},{"key":"B291","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/306067a0","article-title":"Release of Ca2+ from a non-mitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate","volume":"306","author":"Streb","year":"1983","journal-title":"Nature"},{"key":"B292","doi-asserted-by":"publisher","first-page":"26252","DOI":"10.1074\/jbc.M802239200","article-title":"Location and function of STIM1 in the activation of Ca2+ entry signals","volume":"283","author":"Hewavitharana","year":"2008","journal-title":"J Biol Chem"},{"key":"B293","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nrm3414","article-title":"STIM proteins: dynamic calcium signal transducers","volume":"13","author":"Soboloff","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B294","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0143-4160(90)90016-N","article-title":"Capacitative calcium entry revisited","volume":"11","author":"Putney","year":"1990","journal-title":"Cell Calcium"},{"key":"B295","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/355353a0","article-title":"Depletion of intracellular calcium stores activates a calcium current in mast cells","volume":"355","author":"Hoth","year":"1992","journal-title":"Nature"},{"key":"B296","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/cphy.c170031","article-title":"Store-operated calcium entry mediated by ORAI and STIM","volume":"8","author":"Nguyen","year":"2018","journal-title":"Compr Physiol"},{"key":"B297","doi-asserted-by":"publisher","first-page":"9357","DOI":"10.1073\/pnas.0603161103","article-title":"Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B298","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.cub.2009.08.022","article-title":"STIM1 is a calcium sensor specialized for digital signaling","volume":"19","author":"Bird","year":"2009","journal-title":"Curr Biol"},{"key":"B299","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/1523-1747.ep12289726","article-title":"Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate\/cytoskeleton fractions in human keratinocytes","volume":"108","author":"Osada","year":"1997","journal-title":"J Invest Dermatol"},{"key":"B300","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/sj.jidsp.5640197","article-title":"Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C","volume":"4","author":"Kitajima","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"B301","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/JID.2015.403","article-title":"Keratin isotypes control desmosome stability and dynamics through PKC\u03b1","volume":"136","author":"Loschke","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B302","doi-asserted-by":"publisher","first-page":"456841","DOI":"10.1155\/2010\/456841","article-title":"Apoptotic pathways in pemphigus","volume":"2010","author":"Bektas","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"B303","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2051-5960-2-16","article-title":"Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury","volume":"2","author":"Sokolowski","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"B304","doi-asserted-by":"publisher","first-page":"e940","DOI":"10.1038\/cddis.2013.463","article-title":"Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death","volume":"4","author":"Vakifahmetoglu-Norberg","year":"2013","journal-title":"Cell Death Dis"},{"key":"B305","doi-asserted-by":"publisher","first-page":"41175","DOI":"10.1074\/jbc.M105769200","article-title":"The fate of desmosomal proteins in apoptotic cells","volume":"276","author":"Weiske","year":"2001","journal-title":"J Biol Chem"},{"key":"B306","doi-asserted-by":"publisher","first-page":"711","DOI":"10.4049\/jimmunol.182.1.711","article-title":"Involvement of the apoptotic mechanism in pemphigus foliaceus autoimmune injury of the skin","volume":"182","author":"Li","year":"2009","journal-title":"J Immunol"},{"key":"B307","doi-asserted-by":"publisher","first-page":"563091","DOI":"10.4061\/2011\/563091","article-title":"The caspase pathway as a possible therapeutic target in experimental pemphigus","volume":"2011","author":"Pacheco-Tovar","year":"2011","journal-title":"Autoimmune Dis"},{"key":"B308","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/jomfp.JOMFP_79_17","article-title":"Caspase cascade pathways of apoptosis in oral pemphigus: an immunohistochemical study","volume":"22","author":"Sanath","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"B309","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1046\/j.1523-1747.2003.12014.x","article-title":"Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8","volume":"120","author":"Puviani","year":"2003","journal-title":"J Investig Dermatol"},{"key":"B310","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/1523-1747.ep12394858","article-title":"Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes","volume":"103","author":"Sayama","year":"1994","journal-title":"J Investig Dermatol"},{"key":"B311","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/B:APPT.0000018795.05766.1f","article-title":"Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins","volume":"9","author":"Wang","year":"2004","journal-title":"Apoptosis"},{"key":"B312","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1590\/abd1806-4841.20164598","article-title":"Detection of apoptosis in pemphigus vulgaris by TUNEL technique","volume":"91","author":"Cuevas-Gonzalez","year":"2016","journal-title":"An Bras Dermatol"},{"key":"B313","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.febslet.2004.03.107","article-title":"Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes","volume":"566","author":"Pelacho","year":"2004","journal-title":"FEBS Lett"},{"key":"B314","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1111\/exd.13458","article-title":"Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris","volume":"26","author":"Hariton","year":"2017","journal-title":"Exp Dermatol"},{"key":"B315","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fimmu.2018.00370","article-title":"Soluble Fas ligand is essential for blister formation in pemphigus","volume":"9","author":"Lotti","year":"2018","journal-title":"Front Immunol"},{"key":"B316","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1038\/jid.2010.195","article-title":"A previously unreported function of \u03b2(1)B integrin isoform in caspase-8-dependent integrin-mediated keratinocyte death","volume":"130","author":"Lotti","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B317","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1074\/jbc.M109.081570","article-title":"Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology","volume":"285","author":"Marchenko","year":"2010","journal-title":"J Biol Chem"},{"key":"B318","doi-asserted-by":"publisher","first-page":"e0119809","DOI":"10.1371\/journal.pone.0119809","article-title":"Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris","volume":"10","author":"Luyet","year":"2015","journal-title":"PLoS ONE"},{"key":"B319","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1074\/jbc.M508258200","article-title":"The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes","volume":"281","author":"Dusek","year":"2006","journal-title":"J Biol Chem"},{"key":"B320","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1600-0625.2012.01441.x","article-title":"Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris","volume":"21","author":"Gil","year":"2012","journal-title":"Exp Dermatol"},{"key":"B321","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/exd.12088","article-title":"Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase","volume":"22","author":"Espa\u00f1a","year":"2013","journal-title":"Exp Dermatol"},{"key":"B322","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/cr.2009.98","article-title":"Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis","volume":"19","author":"Tomasello","year":"2009","journal-title":"Cell Res"},{"key":"B323","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fchem.2018.00108","article-title":"VDAC1 as pharmacological target in cancer and neurodegeneration: focus on its role in apoptosis","volume":"6","author":"Magr\u00ec","year":"2018","journal-title":"Front Chem"},{"key":"B324","doi-asserted-by":"publisher","first-page":"e81522","DOI":"10.1371\/journal.pone.0081522","article-title":"The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell","volume":"8","author":"Tomasello","year":"2013","journal-title":"PLoS ONE"},{"key":"B325","doi-asserted-by":"publisher","first-page":"111485","DOI":"10.3390\/biom10111485","article-title":"VDAC1 at the intersection of cell metabolism, apoptosis, and diseases","volume":"10","author":"Shoshan-Barmatz","year":"2020","journal-title":"Biomolecules"},{"key":"B326","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.1158\/1078-0432.CCR-06-1037","article-title":"Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis","volume":"12","author":"Yang","year":"2006","journal-title":"Clin Cancer Res"},{"key":"B327","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1073\/pnas.75.1.459","article-title":"Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase","volume":"75","author":"Farb","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"B328","doi-asserted-by":"publisher","first-page":"C162","DOI":"10.1152\/ajpcell.00161.2008","article-title":"Apoptosis is not required for acantholysis in pemphigus vulgaris","volume":"296","author":"Schmidt","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"B329","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0006-2952(03)00497-0","article-title":"Non-apoptotic functions of caspases in cellular proliferation and differentiation","volume":"66","author":"Schwerk","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"B330","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1365-2133.1999.02604.x","article-title":"Internalization of constitutive desmogleins with the subsequent induction of desmoglein 2 in pemphigus lesions","volume":"140","author":"Iwatsuki","year":"1999","journal-title":"Br J Dermatol"},{"key":"B331","doi-asserted-by":"publisher","first-page":"410278","DOI":"10.1155\/2010\/410278","article-title":"Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins","volume":"2010","author":"Brennan","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"B332","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J Investig Dermatol"},{"key":"B333","doi-asserted-by":"publisher","first-page":"581370","DOI":"10.3389\/fimmu.2020.581370","article-title":"Dsg2 upregulation as a rescue mechanism in pemphigus","volume":"11","author":"Sigmund","year":"2020","journal-title":"Front Immunol"},{"key":"B334","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.4049\/jimmunol.1002675","article-title":"Protective endogenous cyclic adenosine 5'-monophosphate signaling triggered by pemphigus autoantibodies","volume":"185","author":"Spindler","year":"2010","journal-title":"J Immunol"},{"key":"B335","doi-asserted-by":"publisher","first-page":"588315","DOI":"10.3389\/fimmu.2020.588315","article-title":"Case report: apremilast for therapy-resistant pemphigus vulgaris","volume":"11","author":"Meier","year":"2020","journal-title":"Front Immunol"},{"key":"B336","doi-asserted-by":"publisher","first-page":"e2000159","DOI":"10.1002\/adbi.202000159","article-title":"Modulation of mechanical stress mitigates anti-Dsg3 antibody-induced dissociation of cell-cell adhesion","volume":"5","author":"Jin","year":"2021","journal-title":"Adv Biol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.701809\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T23:05:14Z","timestamp":1673046314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.701809\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":336,"alternative-id":["10.3389\/fmed.2021.701809"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.701809","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"article-number":"701809"}}