{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:29:34Z","timestamp":1783488574083,"version":"3.55.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Sodium bicarbonate supplementation is a mainstay in the treatment of metabolic acidosis in patients with chronic kidney disease (CKD). Recent studies showed reduction of progression of CKD and reduced all-cause mortality. However, additional sodium loading could worsen arterial hypertension, a well-known contributor to progression of CKD. This patient-relevant and economically negative side effect is under-studied in prospective studies up until now.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> The aim of this study was to analyze the effect of sodium bicarbonate treatment on arterial blood pressure at baseline and after 8 weeks.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The SoBic study is an ongoing randomized controlled trial, in which patients with CKD receive either a high dose of oral sodium bicarbonate or a rescue treatment, if necessary. We used standardized office blood pressure and 24-hour ambulatory blood pressure monitoring (24h-ABPM). Regression models were adjusted for estimated glomerular filtration rate and change of antihypertensives.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 47 subjects were enrolled and the mean age was 57 (\u00b114.6) years and 18 (38%) were female. In 43 randomized subjects with sufficiently performed 24h-ABPM neither systolic 24h-ABPM (2.522; 95%CI: \u22122.364, 7.408; mmHg) nor diastolic 24h-ABPM (0.868; 95%CI: \u22122.411, 4.147; mmHg) was affected by study group allocation. When looking at the effect of individual sodium bicarbonate dose on 24h-ABPM, the fully adjusted model suggested an increase of 0.047 (95%CI: \u22120.026, 0.119) mmHg by each mg\/kg <jats:italic>per<\/jats:italic> day increase of sodium bicarbonate dose.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Sodium bicarbonate supplementation over 8 weeks did not significantly increase blood pressure measured by 24h-ABPM in CKD patients.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> EUDRACT Number: 2012-001824-36; 12\/07\/2012 (<jats:ext-link>https:\/\/www.clinicaltrialsregister.eu<\/jats:ext-link>).<\/jats:p>","DOI":"10.3389\/fmed.2021.711034","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T19:28:11Z","timestamp":1630956491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Oral Sodium Bicarbonate Treatment on 24-Hour Ambulatory Blood Pressure Measurements in Patients With Chronic Kidney Disease and Metabolic Acidosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Martina","family":"Gaggl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Repitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Riesenhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sliber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Fraunschiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cejka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gere","family":"Sunder-Plassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s40620-019-00656-5","article-title":"Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study","volume":"32","author":"Di Iorio","year":"2019","journal-title":"J Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1681\/ASN.2008111205","article-title":"Bicarbonate supplementation slows progression of CKD and improves nutritional status","volume":"20","author":"de","year":"2009","journal-title":"J Am Soc Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/S0140-6736(19)31388-1","article-title":"Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40-week extension","volume":"394","author":"Wesson","year":"2019","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.2215\/CJN.13091118","article-title":"Effects of treatment of metabolic acidosis in CKD: a systematic review and meta-analysis","volume":"14","author":"Navaneethan","year":"2019","journal-title":"Clin J Am Soc Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1053\/j.ajkd.2018.09.004","article-title":"Tolerance to sodium in patients with CKD-induced metabolic acidosis: does the accompanying anion matter?","volume":"73","author":"Bushinsky","year":"2019","journal-title":"Am J Kidney Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/1745-6215-14-196","article-title":"Effect of oral sodium bicarbonate supplementation on progression of chronic kidney disease in patients with chronic metabolic acidosis: study protocol for a randomized controlled trial (SoBic-Study)","volume":"14","author":"Gaggl","year":"2013","journal-title":"Trials."},{"key":"B7","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1136\/bjsports-2018-099921","article-title":"How does exercise treatment compare with antihypertensive medications? 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