{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:30:24Z","timestamp":1784752224186,"version":"3.55.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study aims to investigate the clinical efficacy of laparoscopy and hysteroscopy in the treatment of tubal-factor infertility (TFI) to provide a basis for predicting postoperative pregnancy rates.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The clinical data of 336 patients who underwent laparoscopy and hysteroscopy for TFI between February 2018 and December 2018 in the Department of Reproductive Gynecology at the First People's Hospital of Yunnan were retrospectively analyzed. After implementing the inclusion and exclusion criteria, 278 patients were included in the study. The patients were grouped according to pelvic adhesions, hydrosalpinx, twisted fallopian tubes, and fimbriae structure. The impact of the extent of fallopian tube diseases on postoperative pregnancy outcomes was analyzed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of the 278 patients, 129 got pregnant (pregnancy rate = 46.4%). Pelvic adhesions, hydrosalpinx, twisted\/folded fallopian tubes, and damage to the fimbriae of the fallopian tubes were found to affect the natural pregnancy rate after surgery, and it decreased significantly with the aggravation of the disease (<jats:italic>P<\/jats:italic> &amp;lt; 0.001). Of the 129 patients who had natural pregnancies, 29 had ectopic pregnancies (ectopic pregnancy rate = 22.48%). Twisted\/folded fallopian tubes and damage to the fimbriae structure significantly increased the incidence of postoperative ectopic pregnancy (<jats:italic>P<\/jats:italic> &amp;lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Laparoscopy and hysteroscopy are effective treatments for TFI. Pelvic adhesions, twisted\/folded fallopian tubes, hydrosalpinx, and damage to the fimbriae of the fallopian tubes can affect postoperative pregnancy outcomes and lead to failure of a natural pregnancy after the operation. The incidence of ectopic pregnancy increases with the degree of fallopian tube twisting\/folding and the degree of damage to the fimbriae of the fallopian tubes.<\/jats:p>","DOI":"10.3389\/fmed.2021.712222","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T06:42:21Z","timestamp":1629096141000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of the Clinical Efficacy of Laparoscopy and Hysteroscopy in the Treatment of Tubal-Factor Infertility"],"prefix":"10.3389","volume":"8","author":[{"given":"Lei","family":"Nian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Fen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Feng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"B1","first-page":"351","volume-title":"9 th Edition of Obstetrics and Gynecology","author":"Xie","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/GRF.0b013e3181b08b5f","article-title":"Tubal surgery","volume":"52","author":"Tulandi","year":"2009","journal-title":"Clin Obstetr Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3969\/j.issn.1006-5725.2005.20.036","article-title":"Clinical analysis of laparoscopy and laparotomy in the treatment of tubal infertility","volume":"21","author":"Long","year":"2005","journal-title":"J Pract Med."},{"key":"B4","first-page":"24","article-title":"Clinical effect of salpingoplasty with laparoscopy or laparotomy in treatment of oviduct infertilitas feminis","volume":"2010","author":"Ruan","year":"2010","journal-title":"J Clin Exp Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3969\/j.issn.1006-5725.2005.05.024","article-title":"Endoscopic treatment of 237 cases of infertility: a clinical analysis","volume":"21","author":"Xia","year":"2005","journal-title":"J Pract Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1447-0756.2008.00838.x","article-title":"Should diagnostic laparoscopy be performed initially or not,during infertilitymanagement of primary and secondary infertile women? A cross-sectional study","volume":"35","author":"Kahyaoglu","year":"2009","journal-title":"J Obstet Gynaecol Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/humrep\/den080","article-title":"A safety and efficacy study of a resorbable hydrogel for reduction of post-operative adhesions following myomectomy","volume":"23","author":"Mettler","year":"2008","journal-title":"Hum Reprod."},{"key":"B8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10397-012-0764-2","article-title":"Prevention of adhesions in gynaecological surgery: the 2012 European field guideline","volume":"9","author":"De Wilde","year":"2012","journal-title":"Gynecol Surg."},{"key":"B9","first-page":"40","article-title":"The ectopic pregnancy, a diagnostic and therapeutic challenge","volume":"1","author":"Stucki","year":"2008","journal-title":"J Med Life."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.purol.2010.08.003","article-title":"Adhesions and chronic pelvic pain","volume":"20","author":"Roman","year":"2010","journal-title":"Prog Urol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/humrep\/dei488","article-title":"Benefits and harms of adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study","volume":"21","author":"Mais","year":"2006","journal-title":"Hum Reprod."},{"key":"B12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0140-6736(13)61687-6","article-title":"Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis","volume":"383","author":"Ten","year":"2014","journal-title":"Lancet."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.712222\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T06:42:29Z","timestamp":1629096149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.712222\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":12,"alternative-id":["10.3389\/fmed.2021.712222"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.712222","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]},"article-number":"712222"}}