{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:33:41Z","timestamp":1791581621115,"version":"4.3.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Many patients who have been suffering by C<jats:sc>ovid<\/jats:sc>-19 suffer of long-C<jats:sc>ovid<\/jats:sc> syndrome, with symptoms of fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, and about the serum profile of these patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We studied the blood serum profile of 75 selected patients, with previous confirmed C<jats:sc>ovid<\/jats:sc>-19, 2 months after hospital discharge, who reported new-onset fatigue, muscle weakness and\/or dyspnea not present prior to the virus infection and independently from concomitant diseases and\/or clinical conditions.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72% of patients had clinically significant low levels of hemoglobin and albumin, respectively. Seventy three percentage had elevations in erythrocyte sedimentation rate and CRP. Twenty seven percentage had elevations in LDH.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The co-existence of patient symptoms along with blood markers of coagulation, protein disarrangement and inflammation suggests ongoing alterations in the metabolism, promoting an inflammatory\/hypercatabolic state which maintains a vicious circles implicated in the persistence of PASC. The persistence of altered D-Dimer levels raises the possibility of long-term risks of thromboembolic disease. All these markers levels should be accurately evaluated in the long-term follow-up, with individualized consideration for prophylactic nutritional, anti-inflammatory and\/or anticoagulant therapy if indicated.<\/jats:p>","DOI":"10.3389\/fmed.2021.714426","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T10:05:05Z","timestamp":1626948305000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":76,"title":["Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical 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