{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:26:39Z","timestamp":1772079999066,"version":"3.50.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011196"],"award-info":[{"award-number":["2019A1515011196"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010121"],"award-info":[{"award-number":["2020A1515010121"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Aim:<\/jats:bold> The aim of this study was to investigate the changes in anterior segment parameters as assessed by ultrasound biomicroscopy (UBM) after laser peripheral iridotomy (LPI) and to propose a prediction equation for the width of the angle after LPI.<\/jats:p><jats:p><jats:bold>Design:<\/jats:bold> This was a prospective study.<\/jats:p><jats:p><jats:bold>Participants:<\/jats:bold> The participants included 100 subjects with primary angle closure suspect (PACS).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Anterior segment UBM parameters were measured, whereas AOD750 was chosen to indicate the width of the angle associated with gonioscopic angle closure, as found in a prior study.<\/jats:p><jats:p><jats:bold>Main Outcome Measures:<\/jats:bold> Angle parameters, iris parameters, anterior chamber parameters and ciliary body parameters.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All angle parameters increased after LPI, including the mean angle opening distance at 750 \u03bcm (AOD750), mean angle opening distance at 500 \u03bcm from the scleral spur (AOD500), mean angle opening distance at 750 \u03bcm from the scleral spur (AOD750), and mean angle recess area at 750 \u03bcm from the scleral spur (ARA750). Among iris parameters and ciliary body parameters, the iris thickness at 2,000 \u03bcm (IT2000), iris curvature (IC), and trabecular-ciliary process distance (ICPD) were reduced after LPI. The final equation consisted of four parameters: anterior chamber depth (ACD), iris thickness at 750 \u03bcm from the scleral spur (IT750), AOD750, and lens vault (LV). This equation explained 42.7% of the variability in the angle opening indicator AOD750 after LPI, whereas in the plateau iris configuration subgroup, the accuracy of the prediction equation reached the highest a maximum of 68.6%.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> There was an increase in angle opening and iris flattening after LPI. An equation involving four angle parameters was constructed, this equation which could explained 42.7% of the variability in the angle opening indicator AOD750 after LPI whereas in the plateau iris configuration subgroup, the accuracy of the prediction equation reached a maximum of 68.6%.<\/jats:p>","DOI":"10.3389\/fmed.2021.715747","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T06:36:26Z","timestamp":1628750186000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive Equation for Angle Opening Distance at 750 \u03bcm After Laser Peripheral Iridotomy in Primary Angle Closure Suspects"],"prefix":"10.3389","volume":"8","author":[{"given":"Xinbo","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengguo","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huishan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunru","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingkai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"020705","DOI":"10.7189\/jogh.07.020705","volume":"7","author":"Song","year":"2017","journal-title":"J Glob Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e515","DOI":"10.1111\/j.1755-3768.2011.02146.x","article-title":"Prevalence and risk factors for angle-closure disease in a rural Northeast China population: a population-based survey in Bin County, Harbin","volume":"89","author":"Qu","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ophtha.2006.06.053","article-title":"Laser peripheral iridotomy in primary angle-closure suspects: biometric and gonioscopic outcomes: the Liwan Eye Study","volume":"114","author":"He","year":"2007","journal-title":"Ophthalmology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.ophtha.2018.01.015","article-title":"Laser peripheral iridotomy in primary angle closure: a report by the American academy of ophthalmology","volume":"125","author":"Radhakrishnan","year":"2018","journal-title":"Ophthalmology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/jamaophthalmol.2016.5847","article-title":"Association of Baseline Anterior Segment Parameters With the Development of Incident Gonioscopic Angle Closure","volume":"135","author":"Nongpiur","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/IJG.0000000000000856","article-title":"Ultrasound biomicroscopic diagnosis of angle-closure mechanisms in Vietnamese subjects with unilateral angle-closure glaucoma","volume":"27","author":"Do","year":"2018","journal-title":"J Glaucoma."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.ophtha.2012.01.019","article-title":"Changes in anterior segment morphology after laser peripheral iridotomy: an anterior segment optical coherence tomography study","volume":"119","author":"How","year":"2012","journal-title":"Ophthalmology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3109\/02713683.2012.655396","article-title":"Anatomic predictors for anterior chamber angle opening after laser peripheral iridotomy in narrow angle eyes","volume":"37","author":"Huang","year":"","journal-title":"Curr Eye Res. 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