{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:14:46Z","timestamp":1785554086117,"version":"3.56.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> This study aimed to investigate the difference in the efficacy of pre-operative enteral nutrition (EN) <jats:italic>via<\/jats:italic> a nasogastric tube (NGT) and pre-operative EN <jats:italic>via<\/jats:italic> a nasointestinal tube (NIT) in reducing the incidence of post-operative acalculous acute cholecystitis (AAC) after definitive surgery (DS) for small intestinal fistulas.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Patients with a small intestinal fistula, who had a DS for the disease between January 2015 and March 2021, were enrolled in this study. They were divided into the NIT group and the NGT group based on the pre-operative routes of feeding they received. The clinical characteristics of the two groups were analyzed, and the incidences of post-operative AAC in the two groups were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 200 patients were enrolled in the study, 85 in the NGT group and 115 in the NIT group. Thirty-one patients developed post-operative AAC (8 in the NGT group and 23 in the NIT group). The incidence of post-operative AAC was 15.5%. EN <jats:italic>via<\/jats:italic> the NGT route was associated with a reduction in the incidence of post-operative AAC (adjusted HR = 0.359; 95% CI: 0.139\u20130.931; <jats:italic>P<\/jats:italic> = 0.035).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Pre-operative EN <jats:italic>via<\/jats:italic> the NGT may reduce the incidence of post-operative AAC in patients who received a DS for small intestinal fistulas.<\/jats:p>","DOI":"10.3389\/fmed.2021.721402","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T05:10:50Z","timestamp":1629177050000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Compared With a Nasointestinal Route, Pre-operative Enteral Nutrition via a Nasogastric Tube Reduced the Incidence of Acalculous Acute Cholecystitis After Definitive Surgery for Small Intestinal Fistula"],"prefix":"10.3389","volume":"8","author":[{"given":"Zheng","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cgh.2009.08.034","article-title":"Acute acalculous cholecystitis: a review","volume":"8","author":"Huffman","year":"2010","journal-title":"Clin Gastroenterol 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