{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:45:39Z","timestamp":1772840739085,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> The aim of this study was to evaluate white blood cell (WBC) count as a risk factor related to methotrexate (MTX) treatment failure in patients with ectopic pregnancy (EP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 236 women diagnosed with EP and treated with a single dose of MTX were included. The exposure variable was WBC count at baseline, and the outcome was MTX treatment outcome. Both a multivariate binary logistics regression model and subgroup analysis were performed to evaluate the association between WBC and MTX non-response.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> WBC count was associated with the risk of treatment failure, and the odds ratio (OR) in different multivariate models was stable [minimally adjusted model: OR 1.2, 95% confidence interval (CI): 1.0\u20131.3, <jats:italic>p<\/jats:italic> = 0.008; fully adjusted model: OR 1.2, 95% CI: 1.0\u20131.4, <jats:italic>p<\/jats:italic> = 0.026]. For WBCs in group T3 (&amp;gt;8.9 \u00d7 109\/L), the association between WBC count and treatment failure was significant (minimally adjusted model: OR: 2.0, 95% CI: 1.0\u20133.8, <jats:italic>p<\/jats:italic> = 0.050; fully adjusted model: OR: 2.2, 95% CI: 1.1\u20135.6, <jats:italic>p<\/jats:italic> = 0.034). Subgroup analysis showed that in participants with regular menstruation (OR 1.1, 95% CI: 1.0\u20131.3), WBC count was significantly different from irregular menstruation (OR 1.8, 95% CI: 1.2\u20132.8); <jats:italic>p<\/jats:italic> for interaction was 0.031.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> We found a reliable and non-linear relationship between WBC count and MTX treatment failure for EP.<\/jats:p>","DOI":"10.3389\/fmed.2021.722963","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T04:45:52Z","timestamp":1631249152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between White Blood Cells at Baseline and Treatment Failure of MTX for Ectopic 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