{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:52:08Z","timestamp":1776693128527,"version":"3.51.2"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Psoriasis is a common inflammatory skin condition resulting from the interplay between epidermal keratinocytes and immunological cellular components. This sustained inflammation is essentially driven by pro-inflammatory cytokines with the IL-23\/IL-17 axis playing a critical central role, as proved by the clinical efficacy of their blockade in patients. Among all the CD45R0<jats:sup>+<\/jats:sup>memory T cell subsets, those with special tropism for cutaneous tissues are identified by the expression of the Cutaneous Lymphocyte-associated Antigen (CLA) carbohydrate on their surface, that is induced during T cell maturation particularly in the skin-draining lymph nodes. Because of their ability to recirculate between the skin and blood, circulating CLA<jats:sup>+<\/jats:sup>memory T cells reflect the immune abnormalities found in different human cutaneous conditions, such as psoriasis. Based on this premise, studying the effect of different environmental microbial triggers and psoriatic lesional cytokines on CLA<jats:sup>+<\/jats:sup>memory T cells, in the presence of autologous epidermal cells from patients, revealed important IL-17 cytokines responses that are likely to enhance the pro-inflammatory loop underlying the development of psoriatic lesions. The goal of this mini-review is to present latest data regarding cytokines implicated in plaque and guttate psoriasis immunopathogenesis from the prism of CLA<jats:sup>+<\/jats:sup>memory T cells, that are specifically related to the cutaneous immune system.<\/jats:p>","DOI":"10.3389\/fmed.2021.731911","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T05:50:11Z","timestamp":1635486611000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Human CLA+ Memory T Cell and Cytokines in Psoriasis"],"prefix":"10.3389","volume":"8","author":[{"given":"Carmen","family":"de Jes\u00fas-Gil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00eddia","family":"Sans-de San Nicol\u00e0s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Garc\u00eda-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ferran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Santamaria-Bab\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jaci.2018.10.033","article-title":"Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council","volume":"143","author":"Eyerich","year":"2019","journal-title":"J Allergy Clin Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/exd.13942","article-title":"Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy","volume":"29","author":"Florian","year":"2020","journal-title":"Exp Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1038\/nm.3025","article-title":"A welcome surprise in psoriasis","volume":"18","author":"Krueger","year":"2012","journal-title":"Nat Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.jaad.2009.05.042","article-title":"A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis","volume":"62","author":"Bissonnette","year":"2010","journal-title":"J Am Acad Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jaci.2014.05.046","article-title":"Humanized anti-IFN-\u03b3 (HuZAF) in the treatment of psoriasis","volume":"135","author":"Harden","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0134703","DOI":"10.1371\/journal.pone.0134703","article-title":"First-in-human, phase 1, randomized, dose-escalation trial with recombinant anti-IL-20 monoclonal antibody in patients with psoriasis","volume":"10","author":"Gottlieb","year":"2015","journal-title":"PLoS ONE."},{"key":"B7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1759720X17735756","article-title":"Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness","volume":"9","author":"Tsai","year":"2017","journal-title":"Ther Adv Musculoskelet Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1038\/jid.1983.4","article-title":"Skin-Associated lymphoid tissues (SALT): origins and functions","volume":"80","author":"Wayne Streilein","year":"1983","journal-title":"J Invest Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/40166","article-title":"Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells","volume":"389","author":"Fuhlbrigge","year":"1997","journal-title":"Nature."},{"key":"B10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","article-title":"Control of lymphocyte recirculation in man. 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