{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:12Z","timestamp":1753891272192,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The goal of our study was to evaluate the association of sex and in-hospital mortality in patients with septic shock in Beijing, China.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> We analyzed 3,643 adult patients with septic shock from January 1, 2019, to Dec 31, 2019, in all secondary and tertiary hospitals in Beijing. Study data were retrospectively extracted from the Quality Control Center of Beijing Municipal Health Commission.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were 2,345 (64.37%) male and 1,298 (35.63%) female patients. Compared to male patients, female patients with septic shock had a higher in-hospital mortality rate (55.54 vs. 49.29%, <jats:italic>p<\/jats:italic> &amp;lt; 0.01). The median length of hospitalization stay for male patients was 22.71 days, while that for female patients was 19.72 days (<jats:italic>p<\/jats:italic> &amp;gt; 0.01). Male patients had a higher prevalence of pulmonary infection (68.8 vs. 31.2%, <jats:italic>p<\/jats:italic> &amp;lt; 0.01). The B values of sex in univariate and multivariate logistic regression were \u22120.251 and \u22120.312, respectively. Men had a lower likelihood of hospital mortality than women (OR = 0.732, 95% CI = 0.635\u20130.844, <jats:italic>p<\/jats:italic> = 0.000).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Female patients with septic shock had a higher risk of dying in the hospital than male patients.<\/jats:p>","DOI":"10.3389\/fmed.2021.733410","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T21:36:53Z","timestamp":1634074613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex Differences in In-hospital Mortality of Patients With Septic Shock: An Observational Study Based on Data Analysis From a Cover Sheet of Medical Records in Beijing"],"prefix":"10.3389","volume":"8","author":[{"given":"Xiao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meili","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.anclin.2018.09.007","article-title":"Gender disparities in trauma care: how sex determines treatment, behavior, and outcome","volume":"37","author":"Marcolini","year":"2019","journal-title":"Anesthesiol Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1161\/CIRCULATIONAHA.118.037655","article-title":"Sex differences in in-hospital management and outcomes of patients with acute coronary syndrome","volume":"139","author":"Hao","year":"2019","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/jnr.23955","article-title":"The importance of studying sex differences in disease: The example of multiple sclerosis","volume":"95","author":"Golden","year":"2017","journal-title":"J Neurosci Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.jalz.2018.04.008","article-title":"Understa","volume":"14","author":"Nebel","year":"2018","journal-title":"Alzheimer's Dement."},{"key":"B5","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1007\/s00134-020-05961-3","article-title":"Understanding gender disparities in outcomes after sepsis","volume":"46","author":"Elizabeth Wilcox","year":"2020","journal-title":"Intensive Care Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit Care Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"473.e7","DOI":"10.1016\/j.jcrc.2014.01.002","article-title":"The DISPARITY Study: do gender differences exist in Surviving Sepsis Campaign resuscitation bundle completion, completion of individual bundle elements, or sepsis mortality?","volume":"29","author":"Madsen","year":"2014","journal-title":"J Crit Care"},{"key":"B9","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/SHK.0000000000001253","article-title":"Association of sex with clinical outcome in critically ill sepsis patients: a retrospective analysis of the large clinical database MIMIC-III","volume":"52","author":"Xu","year":"2019","journal-title":"Shock."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1097\/CCM.0b013e3181a569df","article-title":"Gender impact on the outcomes of critically ill patients with nosocomial infections","volume":"37","author":"Combes","year":"2009","journal-title":"Crit Care Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1097\/CCM.0000000000002649","article-title":"MARS Consortium. 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