{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:35:45Z","timestamp":1771486545294,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zone. Axial length, keratometry, astigmatism, and corneal asphericity were also determined.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> This study included 247 patients (420 eyes) with a mean age of 18.1 years. The values of ASA, PSA, and TSA were 0.136 \u00b1 0.100 \u03bcm, \u22120.118 \u00b1 0.030 \u03bcm, and 0.095 \u00b1 0.095 \u03bcm, respectively. In the EL patients with Marfan syndrome (MFS), ASA and TSA were significantly lower than in the non-MFS patients (0.126 \u00b1 0.094 \u03bcm vs. 0.155 \u00b1 0.107 \u03bcm, <jats:italic>P<\/jats:italic> = 0.004 for ASA; 0.085 \u00b1 0.091 \u03bcm vs. 0.114 \u00b1 0.099 \u03bcm, <jats:italic>P<\/jats:italic> = 0.003 for TSA), whereas PSA was not significantly different (<jats:italic>P<\/jats:italic> = 0.061). The values of ASA and TSA were significantly higher in the patients with EL aged \u2265 40 years old than in younger patients, whereas ASA and PSA were lower in patients aged &amp;lt;10 years old than in older patients (all <jats:italic>P<\/jats:italic> &amp;lt; 0.05). In the multiple linear regression analysis, age, keratometry, astigmatism, anterior asphericity, higher-order aberration (HOA), and lower-order aberration (LOA) were positively or negatively correlated with TSA in the patients with EL (<jats:italic>r<\/jats:italic> = 0.681, <jats:italic>P<\/jats:italic> &amp;lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Corneal spherical aberration was low in the patients with EL especially for MFS and tended to increase with aging. Preoperatively, individual measurement of CSA was necessary for bilateral EL patients with MFS.<\/jats:p>","DOI":"10.3389\/fmed.2021.736686","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T04:48:24Z","timestamp":1637297304000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis 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