{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:59:09Z","timestamp":1777395549892,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Subacute thyroiditis is an inflammatory thyroid disorder associated with viral infections. Rare cases of subacute thyroiditis have also been described following vaccination. Recently, a few cases of subacute thyroiditis following SARS-CoV-2 vaccination have also been reported. Here, we present two cases of cytological proven subacute thyroiditis after receiving the first dose of a SARS-CoV-2 vaccination. We describe clinical, laboratory, imaging and cytological findings in two cases of subacute thyroiditis that presented in our department 2 weeks after SARS-CoV-2 vaccination with Spikevax (Moderna Biotech, Spain) and Vaxzevria (AstraZeneca; Sweden). Both cases did not have a previous history of thyroid disorders and presented with anterior and lateral neck pain. Clinical test results as well as cytological findings were consistent with subacute thyroiditis. Subacute thyroiditis may develop following a SARS-CoV-2 vaccination and should be considered as a possible side effect in cases that present with thyroid pain.<\/jats:p>","DOI":"10.3389\/fmed.2021.737142","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:43:30Z","timestamp":1629794610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Case Report: Two Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccination"],"prefix":"10.3389","volume":"8","author":[{"given":"Catherine","family":"Bornemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Woyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bouter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"B1","article-title":"Subacute thyroiditis.","volume-title":"Endotext","author":"Hennessey","year":"2000"},{"key":"B2","first-page":"135","article-title":"Subacute thyroiditis after hepatitis B vaccination","volume":"45","author":"Toft","year":"1998","journal-title":"Endocr J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1607-551X(09)70315-8","article-title":"Subacute thyroiditis following influenza vaccine (Vaxigrip) in a young female","volume":"22","author":"Hsiao","year":"2006","journal-title":"Kaohsiung J Med Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1743-422X-6-5","article-title":"Viruses and thyroiditis: an update","volume":"6","author":"Desailloud","year":"2009","journal-title":"Virol J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/BF03346633","article-title":"Subacute thyroiditis following the H1N1 vaccine","volume":"33","author":"Girgis","year":"2010","journal-title":"J Endocrinol Invest."},{"key":"B6","first-page":"48","article-title":"Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation","volume":"103","author":"Hernan Martinez","year":"2011","journal-title":"Bol Asoc Med P R."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1080\/21645515.2015.1117716","article-title":"Subacute thyroiditis following seasonal influenza vaccination","volume":"12","author":"Altay","year":"2016","journal-title":"Hum Vaccin Immunother."},{"key":"B8","doi-asserted-by":"publisher","first-page":"713","DOI":"10.4103\/ijem.IJEM_237_18","article-title":"Occurrence of subacute thyroiditis following influenza vaccination","volume":"22","author":"Passah","year":"2018","journal-title":"Indian J Endocrinol Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"A956","DOI":"10.1210\/jendso\/bvab048.1954","article-title":"Subacute thyroiditis after mRNA vaccine for Covid-19","volume":"5","author":"Franquemont","year":"2021","journal-title":"J Endocrine Soc."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab373","article-title":"Three cases of subacute thyroiditis following SARS-CoV-2 vaccine: post-vaccination ASIA syndrome","author":"Iremli","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e16045","DOI":"10.7759\/cureus.16045","article-title":"Subacute thyroiditis after receiving the adenovirus-vectored vaccine for coronavirus disease (COVID-19)","volume":"13","author":"Oyibo","year":"2021","journal-title":"Cureus."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0184","article-title":"Letter to the editor: thyroiditis and thyrotoxicosis after the SARS-CoV-2 mRNA vaccine","author":"Schimmel","year":"2021","journal-title":"Thyroid"},{"key":"B13","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1078\/0344-0338-00344","article-title":"Cellular composition of subacute thyroiditis. an immunohistochemical study of six cases","volume":"198","author":"Kojima","year":"2002","journal-title":"Pathol Res Pract."},{"key":"B14","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s12020-021-02689-y","article-title":"Thyroiditis and SARS-CoV-2 pandemic: a review","volume":"72","author":"Caron","year":"2021","journal-title":"Endocrine."},{"key":"B15","doi-asserted-by":"publisher","first-page":"bqaa108","DOI":"10.1210\/endocr\/bqaa108","article-title":"Endocrine significance of SARS-CoV-2's reliance on ACE2","volume":"161","author":"Lazartigues","year":"2020","journal-title":"Endocrinology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1001\/jama.2020.3786","article-title":"Detection of SARS-CoV-2 in different types of clinical specimens","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s40618-020-01436-w","article-title":"Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis","volume":"44","author":"Rotondi","year":"2021","journal-title":"J Endocrinol Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"108480","DOI":"10.1016\/j.clim.2020.108480","article-title":"Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases","volume":"217","author":"Vojdani","year":"2020","journal-title":"Clin Immunol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.737142\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:43:35Z","timestamp":1629794615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.737142\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":18,"alternative-id":["10.3389\/fmed.2021.737142"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2021.737142","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]},"article-number":"737142"}}