{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:33:44Z","timestamp":1781699624697,"version":"3.54.5"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Clinically amyopathic dermatomyositis (CADM) presented with rapid progressive interstitial lung disease (RP-ILD) is rare. Here, we present a case of a post-partum female with CADM complicated by severe RP-ILD managed with venovenous extracorporeal membrane oxygenation (V-V ECMO).<\/jats:p><jats:p><jats:bold>Case Summary:<\/jats:bold> A 36-year-old woman was referred to a local hospital with cough and fever. She had a history of facial erythema and cough since an induction of labor for a stillborn fetus 2 months ago. Her status developed into RP-ILD with mediastinal emphysema and subcutaneous emphysema after admission, and V-V ECMO was initiated. After several failed attempts to wean the patient from ECMO, a decision was made to place the patient on the lung transplant waitlist. She underwent a double lung transplant on ECMO day 31 and received tacrolimus as an immunosuppressive regimen. The patient presented with positive anti-MDA5 and anti-Ro-52 antibodies and a high ferritin level, all of which indicated the presence of clinically amyopathic dermatomyositis (CADM). The patient was weaned from ECMO at 3 days after transplantation, but the patient's state of consciousness deteriorated, and head CT was considered for posterior reversible encephalopathy syndrome (PRES). After the temporary cessation of calcineurin inhibitors and a dosage reduction, the patient's state of consciousness returned to normal. Because of another disturbance of consciousness, the patient declined further treatment and was discharged 14 days after transplantation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Early recognition of CADM can effectively improve patients' prognosis. ECMO should be considered as a supportive therapy in patients in acute respiratory failure secondary to RP-ILD.<\/jats:p>","DOI":"10.3389\/fmed.2021.742823","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T06:09:35Z","timestamp":1633068575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Extracorporeal Membrane Oxgenation for Rapidly Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis in a Post-partum Woman"],"prefix":"10.3389","volume":"8","author":[{"given":"Qiao","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MengYuan","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1111\/bjd.17536","article-title":"The diagnosis and classification of amyopathic dermatomyositis: a historical review and assessment of existing 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adults","volume":"145","author":"Abrams","year":"2014","journal-title":"Chest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1007\/s12035-015-9560-0","article-title":"Posterior reversible encephalopathy syndrome after transplantation: a review","volume":"53","author":"Chen","year":"2016","journal-title":"Mol Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12028-017-0387-6","article-title":"Neurologic complications of transplantation","volume":"28","author":"Dhar","year":"2018","journal-title":"Neurocrit Care."},{"key":"B10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/1346-8138.14092","article-title":"Associations between anti-melanoma differentiation-associated gene 5 antibody and demographics, clinical characteristics and laboratory results of patients with dermatomyositis: a systematic meta-analysis","volume":"45","author":"Li","year":"2018","journal-title":"J Dermatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1093\/rheumatology\/kes102","article-title":"Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis","volume":"51","author":"Gono","year":"2012","journal-title":"Rheumatology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1097\/CM9.0000000000000691","article-title":"Risk factors of interstitial lung diseases in clinically amyopathic dermatomyositis","author":"Gan","year":"2020","journal-title":"Chin Med J"},{"key":"B13","first-page":"113","article-title":"Subcutaneous emphysema, pneumomediastinum and pneumothorax in a patient with dermatomyositis","volume":"29","author":"Bakhshaee","year":"2017","journal-title":"Iran J Otorhinolaryngol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/j.athoracsur.2019.12.044","article-title":"Lung transplant for patient with idiopathic pneumonia syndrome","volume":"110","author":"Said","year":"2020","journal-title":"Ann Thorac Surg."}],"container-title":["Frontiers in 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