{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:09:49Z","timestamp":1793916589347,"version":"4.8.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> To investigate the association of plasma LPS mass with mortality and inflammation in patients with peritonitis-induced septic shock (SS).<\/jats:p><jats:p><jats:bold>Design:<\/jats:bold> Longitudinal endotoxin and inflammatory parameters in a multicentric cohort of SS.<\/jats:p><jats:p><jats:bold>Patients:<\/jats:bold> Protocolized post-operative parameters of 187 SS patients collected at T1 (12 h max post-surgery) and T4 (24 h after T1).<\/jats:p><jats:p><jats:bold>Intervention:<\/jats:bold><jats:italic>Post-hoc<\/jats:italic> analysis of ABDOMIX trial.<\/jats:p><jats:p><jats:bold>Measurements and Results:<\/jats:bold> Plasma concentration of LPS mass as determined by HPLC-MS\/MS analysis of 3-hydroxymyristate, activity of phospholipid transfer protein (PLTP), lipids, lipoproteins, IL-6, and IL-10. Cohort was divided in low (LLPS) and high (HLPS) LPS levels. The predictive value for mortality was tested by multivariate analysis. HLPS and LLPS had similar SAPSII (58 [48.5; 67]) and SOFA (8 [6.5; 9]), but HLPS showed higher death and LPS to PLTP ratio (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). LPS was stable in HLPS, but it increased in LLPS with a greater decrease in IL-6 (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Dead patients had a higher T1 LPS (<jats:italic>p<\/jats:italic> = 0.02), IL-6 (&amp;lt;0.01), IL-10 (=0.01), and day 3 SOFA score (<jats:italic>p<\/jats:italic> = 0.01) than survivors. In the group of SAPSII &amp;gt; median, the risk of death in HLPS (38%) was higher than in LLPS (24%; <jats:italic>p<\/jats:italic> &amp;lt; 0.01). The 28-day death was associated only with SAPSII (OR 1.06 [1.02; 1.09]) and HLPS (OR 2.47 [1; 6.11]) in the multivariate model. In HLPS group, high PLTP was associated with lower plasma levels of IL-6 (<jats:italic>p<\/jats:italic> = 0.02) and IL-10 (<jats:italic>p<\/jats:italic> = 0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Combination of high LPS mass concentration and high SAPS II is associated with elevated mortality in peritonitis-induced SS patients.<\/jats:p>","DOI":"10.3389\/fmed.2021.749405","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T07:07:37Z","timestamp":1635491257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock"],"prefix":"10.3389","volume":"8","author":[{"given":"Didier","family":"Payen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Pais de 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