{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:53:03Z","timestamp":1777290783109,"version":"3.51.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To evaluate the long-term retinal microvascular, neural, and choroidal changes in the patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty-five eyes of 28 patients with treatment-naive severe NPDR and PDR were included and followed for 12 months after PRP. Microvascular and neural changes in the macular and peripapillary areas were assessed by using optical coherence tomography angiography. Subfoveal choroidal thickness (SFCT) was measured by using optical coherence tomography. A Linear mixed-effects model was used to highlight the differences for the variables after adjusting for sex, age, and axial length.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared to baseline, there were no statistical differences in the best corrected visual acuity (BCVA), macular and peripapillary vessel density (VD), and SFCT following PRP. Macular thickness significantly increased at 1 and 3\u20136 months after PRP (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), while the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness significantly increased at 1 month postoperatively (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Global loss volume and focal loss volume significantly decreased at the same time point (<jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The unchanged BCVA, VD, the thickness of RNFL and GCC, and SFCT during the 12-month follow-up period suggest that PRP may prevent the retinal neurovascular and choroidal damage.<\/jats:p>","DOI":"10.3389\/fmed.2021.752538","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T04:25:59Z","timestamp":1634617559000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy"],"prefix":"10.3389","volume":"8","author":[{"given":"Tian","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40662-015-0026-2","article-title":"Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss","volume":"2","author":"Lee","year":"2015","journal-title":"Eye Vis (Lond)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.61.4.29","article-title":"Choroidal thickness in diabetes and diabetic retinopathy: a swept source OCT study","volume":"61","author":"Wang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/iae.0000000000001516","article-title":"Choroildal thickness in diabetic retinopathy assessed with swept-source optical coherence tomography","volume":"38","author":"La\u00edns","year":"2018","journal-title":"Retina."},{"key":"B4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1136\/bjophthalmol-2018-311903","article-title":"Choriocapillaris and retinal vascular plexus density of diabetic eyes using split-spectrum amplitude decorrelation spectral-domain optical coherence tomography angiography","volume":"103","author":"Conti","year":"2019","journal-title":"Br J Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.61.6.1","article-title":"Association between alterations of the choriocapillaris microcirculation and visual function and cone photoreceptors in patients with diabetes","volume":"61","author":"Ro-Mase","year":"2020","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0161-6420(81)34978-1","article-title":"Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8. 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