{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:22:04Z","timestamp":1790968924877,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Maresin 1 plays a role in the regulation of inflammation and metabolic diseases\n                    <jats:italic>in vivo<\/jats:italic>\n                    . An increasing number of studies have reported that postmenopausal osteoporosis (PMOP) is associated with inflammation. However, the potential relationship between the serum Maresin 1 content and PMOP is unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    1) To evaluate the Maresin 1 content in postmenopausal women with osteopenia, osteoporosis, or without these conditions (normal group) and 2) to analyze the correlations between Maresin 1 concentrations and bone mineral density (BMD) and bone turnover markers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    In this cross-sectional study, we measured serum Maresin 1 concentrations, serum biochemical parameters, markers of bone metabolism, and BMD of the femoral neck, lumbar spine, and hip in 141 postmenopausal women.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    We found that serum Maresin 1 in the osteopenia (140.09 \u00b1 30.54 pg\/ml) and PMOP (124.68 \u00b1 31.35 pg\/ml) groups were significantly lower than those in the normal group (167.38 \u00b1 24.85 pg\/ml) (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05 and\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001). Serum Maresin 1 levels were positively correlated with femoral neck, lumbar spine, and hip BMD (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001). Meanwhile, Maresin 1 concentrations were positively associated with 25-hydroxyvitamin D [25(OH)D] levels (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001), but negatively correlated with \u03b2-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (\u03b2-CTX) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002), procollagen type I amino-terminal propeptide (PINP) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004), tartrate-resistant acid phosphatase 5b (TRAP-5b) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005), and osteocalcin (OC) levels (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.001). Multivariate logistic regression analysis showed that a decrease in Maresin 1 concentration was still associated with osteopenia (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.035) or PMOP (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.016). Maresin 1 levels had a maximum area under curve of 0.820 for osteopenia and 0.746 for PMOP (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001). Our results showed that the serum Maresin 1 levels were reduced in osteopenia and PMOP patients compared with that in normal subjects, and were the lowest in the PMOP subjects. The results suggest that Maresin 1 may serve as a new non-invasive diagnostic biomarker for PMOP.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2021.759825","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:28:22Z","timestamp":1641774502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Decreased Serum Maresin 1 Concentration Is Associated With Postmenopausal Osteoporosis: A Cross-Sectional Study"],"prefix":"10.3389","volume":"8","author":[{"given":"Jing","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yuan","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J Bone Miner Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00198-004-1627-0","article-title":"An estimate of the worldwide prevalence, mortality and disability associated with hip fracture","volume":"15","author":"Johnell","year":"2004","journal-title":"Osteoporos Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S615","DOI":"10.1007\/s00198-010-1401-4","article-title":"Outcome in geriatric fracture patients and how it can be improved","volume":"21","author":"Roth","year":"2010","journal-title":"Osteoporos Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. 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