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Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.<\/jats:p>","DOI":"10.3389\/fmed.2021.771297","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T22:28:35Z","timestamp":1640298515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["The Impact of Trace Elements on 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