{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:11:57Z","timestamp":1768349517459,"version":"3.49.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preeclampsia is a serious complication of pregnancy that threatens the safety of the fetus and mother. We assessed the relationship between systolic blood pressure (SBP) in the early pregnancy stage (12 weeks) in patients with preeclampsia and the development of severe eclampsia and birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were categorized based on the quartiles of the prenatal first SBP level. Logistic regression analysis was performed to assess whether prenatal first SBP was a risk factor for low birth weight and severe preeclampsia. The area under the receiver-operating characteristic curve (AUC) of sensitivity and specificity were used to predict the risk of low birth weight and severe preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 333 patients with preeclampsia were enrolled. There were 162 (48.6%) patients with severe preeclampsia and 270 (81.08%) cesareans. Group I patients with a prenatal first SBP \u2264 119 mmHg prenatal had a higher birth weight. Multiple logistic regression analysis showed that serum creatinine (<jats:italic>p<\/jats:italic> = 0.025), prenatal first SBP (<jats:italic>p<\/jats:italic> = 0.029), S-preeclampsia (<jats:italic>p<\/jats:italic> = 0.003), gestational age (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), total cholesterol (TC) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), and low-density lipoprotein (LDL) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) were independent risk factors for low birth weight. Multiple logistic regression analysis showed that prenatal first SBP (<jats:italic>p<\/jats:italic> = 0.003), TC (<jats:italic>p<\/jats:italic> = 0.002), and B-type natriuretic peptide (BNP) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) were independent risk factors for severe preeclampsia. Compared with Group I (SBP \u2264 119 mmHg), the incidence of low birth weight for patients in groups III (131 \u2264 SBP \u2264 138 mmHg) and IV (SBP \u2265 139 mmHg) was significantly higher. Even after correcting for age, gestational age, and biochemical indices, the difference remained statistically significant. The risk of diagnosed severe preeclampsia for patients in Groups IV (SBP \u2265 139 mmHg), III (131 \u2264 SBP \u2264 138 mmHg), and II (120 \u2264 SBP \u2264 130 mmHg) was significantly higher than that in Group I (SBP \u2264 119 mmHg). The AUC of the prenatal first SBP for predicting low birth weight and severe preeclampsia was 0.676 (95% <jats:italic>CI<\/jats:italic> 0.618\u20130.733, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and 0.727 (95% <jats:italic>CI<\/jats:italic> 0.673\u20130.781, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), respectively, in patients with preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prenatal first SBP was associated with birth weight and severe preeclampsia. Higher prenatal first SBP in patients with preeclampsia can predict low birth weight and severe preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2021.771738","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T06:23:34Z","timestamp":1643869414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Value of Prenatal First Systolic Blood Pressure Can Predict Severe Preeclampsia and Birth Weight in Patients With Preeclampsia"],"prefix":"10.3389","volume":"8","author":[{"given":"Bei","family":"Gan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1053\/j.semperi.2011.09.011","article-title":"Maternal mortality from preeclampsia\/eclampsia","volume":"36","author":"Ghulmiyyah","year":"2012","journal-title":"Semin Perinatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/GCO.0b013e32835e0ef5","article-title":"Hypertensive disease of pregnancy and maternal mortality","volume":"25","author":"Lo","year":"2013","journal-title":"Curr Opin Obstet Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","article-title":"Report on the American College of Obstetricians and Gynecologists' task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/molehr\/gau105","article-title":"Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development","volume":"21","author":"Cindrova-Davies Tissot van patot","year":"2015","journal-title":"Mol Hum Reprod."},{"key":"B5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1161\/01.HYP.0000251522.18094.d4","article-title":"Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?","volume":"49","author":"Germain","year":"2007","journal-title":"Hypertension."},{"key":"B6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1081\/PRG-120021066","article-title":"Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States","volume":"22","author":"Zhang","year":"2003","journal-title":"Hypertens Pregnancy."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1172\/JCI119387","article-title":"Human cyotrophoblasts adopt a vascular phenotype as they differentiate. a strategy for successful endovascular invasion?","volume":"99","author":"Zhou","year":"1997","journal-title":"J Clin Invest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1172\/JCI119388","article-title":"Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. 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