{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:05:52Z","timestamp":1753891552150,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2218-E-006-017"],"award-info":[{"award-number":["MOST 110-2218-E-006-017"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score has been evaluated for predicting new onset atrial fibrillation, but never for adverse systemic thromboembolic events (STE) in elderly. We aimed to evaluate the HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score and comparing to atrial high rate episodes (AHRE) \u226524 h for predicting STE in older patients with cardiac implantable electronic devices (CIED) implantation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We retrospective enrolled 219 consecutive patients \u2265 65 years of age undergoing CIED implantation. The primary endpoint was subsequent STE. For all patients in the cohort, the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc, C<jats:sub>2<\/jats:sub>HEST, mC<jats:sub>2<\/jats:sub>HEST, HAVOC, HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> scores and AHRE \u2265 24 h were determined. AHRE was defined as &amp;gt; 175 bpm lasting \u2265 30 s. Multivariate Cox regression analysis with time-dependent covariates was used to determine variables associated with independent risk of STE.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The median patient age was 77 years, and 61.2% of the cohort was male. During follow-up (median, 35 months), 16 STE occurred (incidence rate, 2.51\/100 patient-years; 95% CI, 1.65\u20135.48). Multiple Cox regression analysis showed that the HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score (HR, 3.405; 95% CI, 2.272\u20135.104; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) was an independent predictor for STE. The optimal HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score cutoff value was 3, with the highest Youden index (AUC, 0.907; 95% CI, 0.853\u20130.962; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The STE rate increased with increasing HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score (<jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This study is the first to show the prognostic value of the HAT<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub> score for STE occurrence in older patients with CIEDs.<\/jats:p>","DOI":"10.3389\/fmed.2021.786779","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T06:20:22Z","timestamp":1640326822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["HAT2CH2 Score Predicts Systemic Thromboembolic Events in Elderly After Cardiac Electronic Device Implantation"],"prefix":"10.3389","volume":"8","author":[{"given":"Ju-Yi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tse-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Da","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1111\/j.1532-5415.1999.tb05239.x","article-title":"Permanent pacemakers in older persons","volume":"47","author":"Gregoratos","year":"1999","journal-title":"J Am Geriatr Soc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1111\/jgs.16099","article-title":"Implantable cardioverter-defibrillators and cardiac resynchronization therapy in older adults with heart 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