{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:36Z","timestamp":1753891296095,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral veins. Pulmonary emboli have been reported rarely. We present a case of a young male patient who developed severe thrombocytopenia and pulmonary embolism 12 days after the first dose of the vaccine. Severe thrombocytopenia, skin hematomas, and segmental pulmonary emboli were detected. Anti-platelet factor 4 (aPF-4) antibody was highly positive supporting the diagnosis of VITT. Prompt treatment with fondaparinux, intravenous immunoglobulin, and prednisone led to a marked improvement of clinical condition and thrombocytes count. We report the first known case of VITT in Slovakia.<\/jats:p>","DOI":"10.3389\/fmed.2021.789972","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T08:09:42Z","timestamp":1641283782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia"],"prefix":"10.3389","volume":"8","author":[{"given":"Martin","family":"Ihnatko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Truchla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L'udmila","family":"Ihnatkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Proh\u00e1szka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivica","family":"Laz\u00farov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"B1","unstructured":"2021"},{"key":"B2","doi-asserted-by":"publisher","first-page":"102663","DOI":"10.1016\/j.jaut.2021.102663","article-title":"Perspectives on vaccine induced thrombotic thrombocytopenia","volume":"121","author":"Dotan","year":"2021","journal-title":"J Autoimmun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1055\/s-0040-1718532","article-title":"Venous thromboembolism in COVID-19","volume":"120","author":"Schulman","year":"2020","journal-title":"Thromb Haemost."},{"key":"B4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/thoraxjnl-2020-216243","article-title":"COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms","volume":"76","author":"Loo","year":"2021","journal-title":"Thorax."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1056\/NEJMoa2104882","article-title":"Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination","volume":"384","author":"Schultz","year":"2021","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2450\/2021.0131-21","article-title":"A case of vaccine-induced immune thrombotic thrombocytopenia with massive artero-venous thrombosis","volume":"19","author":"Turi","year":"2021","journal-title":"Blood Transfus."},{"key":"B7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.5694\/mja2.51135","article-title":"The first known case of vaccine-induced thrombotic thrombocytopenia in Australia","volume":"215","author":"Hocking","year":"2021","journal-title":"Med J Aust."},{"key":"B8","doi-asserted-by":"publisher","first-page":"002692","DOI":"10.12890\/2021_002692","article-title":"Renal vein thrombosis and pulmonary embolism secondary to vaccine-induced thrombotic thrombocytopenia (VITT)","volume":"8","author":"Cliff-Patel","year":"2021","journal-title":"Eur J Case Rep Intern Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1182\/blood.2021012152","article-title":"Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know","volume":"138","author":"Arepally","year":"2021","journal-title":"Blood."},{"key":"B10","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1055\/a-1499-0119","article-title":"SARS-CoV-2 vaccine and thrombosis: an expert consensus on vaccine-induced immune thrombotic thrombocytopenia","volume":"121","author":"Elalamy","year":"2021","journal-title":"Thromb Haemost."},{"key":"B11","doi-asserted-by":"publisher","first-page":"102662","DOI":"10.1016\/j.jaut.2021.102662","article-title":"Mechanisms of immunothrombosis in vaccine-induced thrombotic thrombocytopenia (VITT) compared to natural SARS-CoV-2 infection","volume":"121","author":"McGonagle","year":"2021","journal-title":"J Autoimmun."},{"key":"B12","article-title":"Recognizing vaccine-induced immune thrombotic thrombocytopenia","volume-title":"Crit Care Med.","author":"Iba","year":"2021"},{"key":"B13","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41586-021-03744-4","article-title":"Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia","volume":"596","author":"Huynh","year":"2021","journal-title":"Nature."},{"key":"B14","doi-asserted-by":"publisher","first-page":"E346","DOI":"10.1002\/ajh.26265","article-title":"Vaccine-induced thrombotic thrombocytopenia following Ad26","volume":"96","author":"Abou-Ismail","year":"2021","journal-title":"Am J Hematol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1056\/NEJMoa2109908","article-title":"Clinical features of vaccine-induced immune thrombocytopenia and thrombosis","volume":"385","author":"Pavord","year":"2021","journal-title":"N Engl J Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1055\/s-0040-1712097","article-title":"Pulmonary embolism or pulmonary thrombosis in COVID-19? 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