{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:46:41Z","timestamp":1779900401349,"version":"3.53.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30CA236031"],"award-info":[{"award-number":["F30CA236031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Oral iron supplements are commonly administered to patients with chronic iron deficiency anemia. This approach is generally well-tolerated, causing only mild adverse effects. Rarely, oral iron supplementation can cause more severe symptoms, one of the most concerning being acute gastritis. This predominantly affects elderly patients and is extremely uncommon in young, otherwise healthy people. Here, we report the case of a 43-year-old woman who presented with upper gastrointestinal (GI) symptoms and iron deficiency anemia and was started on oral iron supplementation following the resolution of her acute symptoms. She soon re-presented with a severe, <jats:italic>Helicobacter pylori<\/jats:italic>-negative gastritis with iron deposition on histology. These new onset symptoms resolved rapidly with cessation of iron supplements, consistent with iron pill gastritis. In addition to the limited body of literature describing iron pill gastritis, this case serves as a reminder that any patient receiving oral iron supplementation is at a potential risk for gastritis, particularly in the setting of an ongoing GI pathology. Hence, it is important to provide continued follow-up for patients receiving iron supplementation regardless of age or comorbidity, particularly in the weeks following the start of the treatment.<\/jats:p>","DOI":"10.3389\/fmed.2022.1010897","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T10:11:26Z","timestamp":1667470286000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case report: Rapid onset, ischemic-type gastritis after initiating oral iron supplementation"],"prefix":"10.3389","volume":"9","author":[{"given":"Regina M.","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Tchernodrinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Principe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0140-6736(07)61235-5","article-title":"Nutritional iron deficiency.","volume":"370","author":"Zimmermann","year":"2007","journal-title":"Lancet."},{"key":"B2","author":"Nguyen","year":"2022","journal-title":"Iron Supplementation."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e8234","DOI":"10.7759\/cureus.8234","article-title":"Iron overload in gastric mucosa: underdiagnosed condition rarely documented in clinical and pathology reports.","volume":"12","author":"Onorati","year":"2020","journal-title":"Cureus."},{"key":"B4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.14740\/gr804w","article-title":"Iron pill gastritis: an under diagnosed condition with potentially serious outcomes.","volume":"10","author":"Sunkara","year":"2017","journal-title":"Gastroenterol Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/j.1365-2559.2006.02448.x","article-title":"Iron-induced mucosal injury to the upper gastrointestinal tract.","volume":"48","author":"Haig","year":"2006","journal-title":"Histopathology."},{"key":"B6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/1066896913502230","article-title":"Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II).","volume":"22","author":"De Petris","year":"2014","journal-title":"Int J Surg Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/BF01535729","article-title":"Effect of oral iron therapy on the upper gastrointestinal tract. A prospective evaluation.","volume":"33","author":"Laine","year":"1988","journal-title":"Dig Dis Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1097\/00000478-199910000-00009","article-title":"Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity.","volume":"23","author":"Abraham","year":"1999","journal-title":"Am J Surg Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1042\/bj2410273","article-title":"Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?","volume":"241","author":"Aruoma","year":"1987","journal-title":"Biochem J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.14309\/crj.2013.7","article-title":"Iron pill-induced gastritis.","volume":"1","author":"Hashash","year":"2013","journal-title":"ACG Case Rep J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e524","DOI":"10.1016\/S2352-3026(17)30182-5","article-title":"Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.","volume":"4","author":"Stoffel","year":"2017","journal-title":"Lancet Haematol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3324\/haematol.2019.220830","article-title":"Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women.","volume":"105","author":"Stoffel","year":"2020","journal-title":"Haematologica."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.4103\/jfmpc.jfmpc_559_20","article-title":"Oral versus intravenous iron therapy in iron deficiency anemia: an observational study.","volume":"9","author":"Das","year":"2020","journal-title":"J Fam Med Prim Care."},{"key":"B14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1185\/03007995.2012.761599","article-title":"Tolerability of different oral iron supplements: a systematic review.","volume":"29","author":"Cancelo-Hidalgo","year":"2013","journal-title":"Curr Med Res Opin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0117383","DOI":"10.1371\/journal.pone.0117383","article-title":"Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis.","volume":"10","author":"Tolkien","year":"2015","journal-title":"PLoS One."},{"key":"B16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000334877","article-title":"Efficacy and tolerability of accelerated-dose low-molecular-weight iron dextran (cosmofer) in patients with chronic kidney disease.","volume":"35","author":"Cooke","year":"2012","journal-title":"Am J Nephrol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1046\/j.1523-1755.1999.055Suppl.69061.x","article-title":"Strategies for iron supplementation: oral versus intravenous.","volume":"69","author":"Macdougall","year":"1999","journal-title":"Kidney Int Suppl."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(07)60689-8","article-title":"Clinical update: intravenous iron for anaemia.","volume":"369","author":"Auerbach","year":"2007","journal-title":"Lancet."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1010897\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T10:11:33Z","timestamp":1667470293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1010897\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":18,"alternative-id":["10.3389\/fmed.2022.1010897"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1010897","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,3]]},"article-number":"1010897"}}