{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:48:44Z","timestamp":1792900124563,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Vasculitides, characterized by inflammation and damage of blood vessels, encompass a broad spectrum of diseases. They can occur with different pathophysiological mechanisms and have a rich clinical heterogeneity depending on the vessel diameters they affect. Vasculitides may also present with a broad spectrum of severity, ranging from a mild self-limiting to a potentially life-threatening disease. The high prevalence of skin involvement in vasculitis, visible character and, finally, the easy accessibility of the skin for both physical examination and biopsy offers important advantages for prompt disease recognition and diagnosis. Thus, dermatologists are privileged to diagnose the disease earlier and more effectively than any other discipline. As a consequence, a detailed clinical and histopathological evaluation of the skin is one of the most critical steps in diagnosing vasculitis. Besides obtaining a good medical history, laboratory and radiological evaluation methods are used in the diagnosis. In this review, a practical and algorithmic approach is aimed to assist in the diagnosis of vasculitis. However, this approach should not be seen as strict rules. This stepwise algorithmic diagnostic approach for vasculitis was developed by combining the current literature knowledge and the author's experience in this field to provide a rational framework for selecting the most appropriate among various diagnostic approaches.<\/jats:p>","DOI":"10.3389\/fmed.2022.1012554","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:44:21Z","timestamp":1663721061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Cutaneous vasculitis; An algorithmic approach to diagnosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Erkan","family":"Alpsoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/art.40375","article-title":"Nomenclature of cutaneous vasculitis: dermatologic addendum to the 2012 revised international chapel hill consensus conference nomenclature of vasculitides","volume":"70","author":"Sunderk\u00f6tter","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s40257-014-0076-6","article-title":"A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis","volume":"15","author":"Goeser","year":"2014","journal-title":"Am J Clin Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.clindermatol.2017.08.004","article-title":"Vasculitis: Kids are not just little people","volume":"35","author":"Lakdawala","year":"2017","journal-title":"Clin Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.mayocp.2014.04.015","article-title":"Incidence of leukocytoclastic vasculitis, 1996 to 2010: a population-based study in Olmsted County, Minnesota","volume":"89","author":"Arora","year":"2014","journal-title":"Mayo Clin Proc."},{"key":"B5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12016-020-08788-4","article-title":"Cutaneous vasculitis: review on diagnosis and clinicopathologic correlations","volume":"61","author":"Frumholtz","year":"2021","journal-title":"Clin Rev Allergy Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/BOR.0000000000000563","article-title":"An update on the nomenclature for cutaneous vasculitis","volume":"31","author":"Caproni","year":"2019","journal-title":"Curr Opin Rheumatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.abd.2020.01.003","article-title":"Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis- part I","volume":"95","author":"Morita","year":"2020","journal-title":"An Bras Dermatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/S0190-9622(86)70064-9","article-title":"Cutaneous granulomatous vasculitis: its relationship to systemic disease","volume":"14","author":"Gibson","year":"1986","journal-title":"J Am Acad Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/00005792-199811000-00006","article-title":"Cutaneous vasculitis in children and adults. 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