{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:14:58Z","timestamp":1776435298645,"version":"3.51.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the present study was to investigate the clinical features of peripapillary regions in patients with myopic macular retinoschisis (MRS) and its association with the development of retinoschisis (RS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross-sectional study, high-myopic patients with or without MRS were recruited, and the hypodense regions were analyzed in the peripapillary regions. The vitreoretinal adhesions around both macular and paravascular arcades were compared between groups. The risk factors for the development of MRS were analyzed by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 88 myopic eyes, MRS was detected in 45 eyes (51%). The eyes with MRS showed a higher rate of peripapillary and paravascular retinoschisis (<jats:italic>P<\/jats:italic> &amp;lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.006). Hypodense regions were detected in 25 eyes (20.35%). Higher rates of horizontal and vertical macular MRS were detected in the hypodense group (<jats:italic>P<\/jats:italic> = 0.012 and <jats:italic>P<\/jats:italic> = 0.002). Lower refractive error, longer axial length, and higher rates of outer retinoschisis both in horizontal and vertical macular regions were observed in the hypodense group (<jats:italic>P<\/jats:italic> = 0.012, <jats:italic>P<\/jats:italic> = 0.006, <jats:italic>P<\/jats:italic> = 0.038, and <jats:italic>P<\/jats:italic> = 0.034). Higher rates of inner and outer retinoschisis, vitreoschisis, and microfolds along superior vascular arcade were detected in the hypodense group (<jats:italic>P<\/jats:italic> = 0.005, <jats:italic>P<\/jats:italic> = 0.001, <jats:italic>P<\/jats:italic> = 0.014, and <jats:italic>P<\/jats:italic> = 0.014). Higher rates of internal limiting membrane (ILM) detachment, inner and outer RS were detected along the inferior vascular arcade in the hypodense group (<jats:italic>P<\/jats:italic> = 0.008, <jats:italic>P<\/jats:italic> = 0.001, and <jats:italic>P<\/jats:italic> = 0.028). Hypodense regions, the axial length and PICC (peripapillary intrachoroidal cavitation) were significantly correlated with the severity of MRS (Odds ratio = 0.207, <jats:italic>P<\/jats:italic> = 0.010; Odds ratio = 1.399, <jats:italic>P<\/jats:italic> = 0.016; Odds ratio = 0.142, <jats:italic>P<\/jats:italic> = 0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The hypodense regions were likely to affect outer retinoschisis both in macular and paravascular regions. It was a risk factor for the development of MRS.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.1018580","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T06:00:10Z","timestamp":1669960810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypodense regions in the peripapillary region increased the risk of macular retinoschisis detected by optical coherence 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