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Med."],"abstract":"<jats:p>Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and\/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option.<\/jats:p>","DOI":"10.3389\/fmed.2022.1023458","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T06:42:15Z","timestamp":1671172935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab"],"prefix":"10.3389","volume":"9","author":[{"given":"Si-Zhe","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Han","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou-Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Gang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.3389\/fimmu.2019.01389","article-title":"Lichen planus pemphigoides: from lichenoid inflammation to autoantibody-mediated blistering","volume":"10","author":"H\u00fcbner","year":"2019","journal-title":"Front Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e15387","DOI":"10.1111\/dth.15387","article-title":"A 10-year survey on lichen planus pemphigoides in Iran: a therapeutic conundrum","volume":"35","author":"Balighi","year":"2022","journal-title":"Dermatol Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1365-4632.2012.05693.x","article-title":"Lichen planus pemphigoides: four new cases and a review of the literature","volume":"52","author":"Zaraa","year":"2013","journal-title":"Int J Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"adv00156","DOI":"10.2340\/00015555-3523","article-title":"Non-bullous lichen planus pemphigoides: a case report","volume":"100","author":"Lamberts","year":"2020","journal-title":"Acta Derm Venereol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/ajd.12306","article-title":"Non-bullous lichen planus pemphigoides possibly induced by venlafaxine","volume":"57","author":"Tan","year":"2016","journal-title":"Australas J Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/ajd.13808","article-title":"Challenges and pitfalls between lichen planus pemphigoides and bullous lichen planus","volume":"63","author":"Papara","year":"2022","journal-title":"Australas J Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1002\/ski2.94","article-title":"Severe childhood lichen planus pemphigoides after hepatitis A vaccination","volume":"2","author":"Lahouel","year":"2022","journal-title":"Skin Health Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jdcr.2020.03.008","article-title":"Childhood erythrodermic lichen planus pemphigoides after nonavalent human papillomavirus vaccination","volume":"6","author":"Pizzatti","year":"2020","journal-title":"JAAD Case Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus: report of an international consensus meeting. 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