{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:14:59Z","timestamp":1763968499742,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Primary thyroid osteosarcoma is an extremely rare tumor which is associated with a poor prognosis. In this study, we describe an additional case. A 4.5 \u00d7 3.8 cm irregular heterogeneous nodule was examined in the left thyroid gland of a 72-year-old woman. Cytological smears and histopathological specimens showed typical features of osteosarcoma with a neoplastic lesion rich in spindle cells with occasional multinucleated cells and lace-like osteoid matrix. Negative immunoreaction with epithelial markers and positive immunoreaction with SATB2 and low Ki-67 labeling index suggested the diagnosis of osteosarcoma. Multiple <jats:italic>KMT2C<\/jats:italic> gene mutations determined by next-generation sequencing further confirmed the diagnosis.<\/jats:p>","DOI":"10.3389\/fmed.2022.1030888","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T06:07:00Z","timestamp":1667887620000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["KMT2C mutation is a diagnostic molecular marker for primary thyroid osteosarcoma: A case report and literature review"],"prefix":"10.3389","volume":"9","author":[{"given":"Xinpei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3760\/cma.j.issn.0253-3766.2018.12.014","article-title":"[Chronic lymphocytic thyroiditis accompanied with primary osteosarcoma of thyroid : a case report and literature review].","volume":"40","author":"Ren","year":"2018","journal-title":"Zhonghua Zhong Liu Za Zhi."},{"key":"B2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/RLU.0b013e3181e05f30","article-title":"Primary thyroid osteosarcoma: staging and evaluation of response to therapy with F-18 Fdg Pet-Ct.","volume":"35","author":"Makis","year":"2010","journal-title":"Clin Nucl Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.5114\/wo.2013.33783","article-title":"Primary osteosarcoma of the thyroid gland \u2013 a case report.","volume":"17","author":"Zembala-No\u017cy\u0144ska","year":"2013","journal-title":"Contemp Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/dc.20840","article-title":"Fine-needle aspiration biopsy of primary osteosarcoma of the thyroid: report of a case and review of the literature.","volume":"36","author":"Tong","year":"2008","journal-title":"Diagn Cytopathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1055\/s-2006-925096","article-title":"[Extraosseous osteosarcoma of the thyroid gland].","volume":"85","author":"Hertel","year":"2006","journal-title":"Laryngorhinootologie."},{"key":"B6","first-page":"840","article-title":"[Primary Osteosarcoma of the Thyroid Gland].","volume":"124","author":"Strohschneider","year":"1999","journal-title":"Zentralbl Chir."},{"key":"B7","first-page":"1399","article-title":"Primary osteosarcoma of the thyroid gland.","volume":"33","author":"Nitzsche","year":"1992","journal-title":"J Nucl Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/bf00408105","article-title":"Fine needle aspiration cytology of the thyroid osteosarcoma. report of a case.","volume":"96","author":"Syrj\u00e4nen","year":"1980","journal-title":"J Cancer Res Clin Oncol."},{"key":"B9","first-page":"623","article-title":"An osteogenic sarcoma of the thyroid gland (report of a case and survey of the literature).","volume":"26","author":"Syrj\u00e4nen","year":"1979","journal-title":"Neoplasma."},{"key":"B10","first-page":"141","article-title":"[A case of primary osteogenetic sarcoma of the thyroid gland. 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