{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:20:16Z","timestamp":1779297616107,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Analysis the outcomes of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> prosthetic joint infection (PJI), and of their clinical and microbiological characteristics, surgical strategies and antibiotic treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Monocenter cohort study in a Bone-and-Joint-Infection Referral Center (08\/2004 to 10\/2018) including all consecutive <jats:italic>P. aeruginosa<\/jats:italic> PJIs. Data were extracted from the prospective database, including the following events: relapses, new PJIs, related deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median [IQR]: among the 43 patients included (28 females; 72 [63\u201380] years old; 27 hip, 15 knee, and 1 shoulder PJIs), 29 (67%) had underlying comorbidities, 12 (28%) had previously been treated for another PJI and 9 (21%) had undergone previous surgeries for their <jats:italic>P. aeruginosa<\/jats:italic> PJI. Eleven (26%) PJIs were polymicrobial, 16 (37%) strains were wild type, 8 (19%) ciprofloxacin-resistant. PJIs were classified as late chronic (<jats:italic>n<\/jats:italic> = 33), early postoperative (<jats:italic>n<\/jats:italic> = 9) or acute hematogenous infection (<jats:italic>n<\/jats:italic> = 1). Forty patients underwent surgery: 27 one-stage and 5 two-stage exchanges, 3 debridement and implant retention, and 5 other surgical strategies. Antibiotic treatments were: 29 received 41 [37\u201343] days of combination therapy (IV anti-pseudomonal \u03b2-lactam and 3\u20135 days of amikacin, then \u03b2-lactam and oral ciprofloxacin), followed by oral ciprofloxacin for a total of 12 weeks; 10 received only IV antibiotics for 83 [77\u201386] days, including 37 [32\u201346] days of combination therapy; 49 days of ceftazidime alone for 1. During follow-up lasting 33 [24\u201364.5] months, 2 relapses, 3 new PJIs, and 2 related deaths occurred. Thirty-three (82%) patients and 93% of those managed with one-stage exchange experienced no event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes of our cohort\u2019s <jats:italic>P. aeruginosa<\/jats:italic> PJIs\u2014predominantly monomicrobial, chronic, ciprofloxacin-susceptible, treated with one-stage exchange and prolonged IV antibiotics\u2014were 82% favorable.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.1039596","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T15:28:45Z","timestamp":1670513325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Pseudomonas aeruginosa prosthetic joint-infection outcomes: Prospective, observational study on 43 patients"],"prefix":"10.3389","volume":"9","author":[{"given":"H\u00e9lo\u00efse","family":"Pri\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanina","family":"Meyssonnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younes","family":"Kerroumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Heym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lidove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Marmor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.otsr.2017.11.019","article-title":"Ten-year survival and complications of total knee arthroplasty for osteoarthritis secondary to trauma or surgery: a French multicentre study of 263 patients","volume":"104","author":"Putman","year":"2018","journal-title":"Orthop Traumatol Surg Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2106\/JBJS.G.00587","article-title":"Future clinical and economic impact of revision total hip and knee arthroplasty","volume":"89","author":"Kurtz","year":"2007","journal-title":"J Bone Joint Surg Am."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the infectious diseases society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jinf.2017.12.016","article-title":"Analysis of postoperative and hematogenous prosthetic joint-infection microbiological patterns in a large cohort","volume":"76","author":"Zeller","year":"2018","journal-title":"J Infect."},{"key":"B5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cmi.2018.04.035","article-title":"Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study","volume":"25","author":"Triffault-Fillit","year":"2019","journal-title":"Clin Microbiol Infect."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1016\/j.arth.2017.01.027","article-title":"Specific infectious organisms associated with poor outcomes in treatment for hip periprosthetic infection","volume":"32","author":"Cunningham","year":"2017","journal-title":"J Arthroplasty."},{"key":"B7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.5301\/jabfm.5000209","article-title":"Risk factors for failure in early prosthetic joint infection treated with debridement. 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