{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:50:58Z","timestamp":1777139458276,"version":"3.51.4"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>An intraretinal macrocyst is a cavity located in the outer plexiform layer of the retina. It is commonly filled with liquid or blood. To date, few case reports of intraretinal macrocysts with crystalline content and retinal detachment have been published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 44-year-old woman with no history of other diseases complained of decreased vision in her right eye that had persisted for 20 days. The best corrected visual acuity of the right eye was hand motion. Comprehensive ophthalmic examinations were performed, including a vision test, slit lamp fundus examination, ocular B-scan ultrasound, and orbital magnetic resonance imaging. We performed vitrectomy and retinotomy to sufficiently remove the macrocyst and relieve retinal traction. We then reattached the retina and filled it with silicone oil. During the surgery, we found that the cyst had crystalline content, which has not been previously reported, to the best of our knowledge. Finally, the pathological results confirmed a final diagnosis of intraretinal macrocyst. Six months later, we performed a second operation to remove the silicone oil and implant an intraocular lens. After both surgeries, the best corrected visual acuity of the patient's right eye was restored to 20\/200, and the retina had repositioned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraretinal macrocysts are very rare. Both orbital magnetic resonance imaging and ocular B-scan ultrasound are essential for their diagnosis. Our results indicated that vitrectomy was the best way to remove the cyst and reattach the retina.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.1051181","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T06:41:48Z","timestamp":1671086508000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case report: An intraretinal macrocyst with crystalline content and retinal detachment"],"prefix":"10.3389","volume":"9","author":[{"given":"Chang","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihou","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/bjo.50.11.617","article-title":"Retinal cysts and retinoschisis","volume":"50","author":"Keith","year":"1966","journal-title":"Br J Ophthalmol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.5301\/ejo.5000034","article-title":"Intraretinal cyst secondary to longstanding retinal detachment","volume":"22","author":"Verdaguer","year":"2012","journal-title":"Eur J Ophthalmol."},{"key":"B3","first-page":"442","article-title":"Intraretinal macrocysts and retinal detachment","volume":"71","author":"Hagler","year":"1967","journal-title":"Trans Am Acad Ophthalmol Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4103\/ojo.OJO_136_2018","article-title":"Retinal detachment with hemorrhagic intraretinal macrocyst clinically presenting as pseudo-choroidal melanoma","volume":"12","author":"Naik","year":"2019","journal-title":"Oman J Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000363759","article-title":"Clinical and echographic long-term follow-up of a retinal macrocyst: a case report","volume":"5","author":"Serna-Ojeda","year":"2014","journal-title":"Case Rep Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4103\/jovr.jovr_210_16","article-title":"Ocular toxoplasmosis presenting as subretinal macrocyst","volume":"14","author":"Karimi","year":"2019","journal-title":"J Ophthalmic Vis Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3928\/23258160-20140501-04","article-title":"Idiopathic giant retinal cyst","volume":"45","author":"Chen","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina."},{"key":"B8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/IMCRJ.S47769","article-title":"Resolution of exudative retinal detachment and regression of retinal macrocyst post-laser in Coats disease","volume":"6","author":"Munira","year":"2013","journal-title":"Int Med Case Rep J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/08820530802508561","article-title":"Chronic retinal detachment with secondary retinal macrocyst and peripheral neovascularization","volume":"24","author":"Labriola","year":"2009","journal-title":"Semin Ophthalmol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.4103\/ijo.IJO_2336_19","article-title":"Surgical management of a large retinal cyst in X-linked retinoschisis with internal drainage: Report of an unusual case","volume":"68","author":"Sen","year":"2020","journal-title":"Indian J Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4103\/0974-620X.77660","article-title":"Hemorrhagic intraretinal macrocyst: Differential diagnoses and report of an unusual case","volume":"4","author":"Rishi","year":"2011","journal-title":"Oman J Ophthalmol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1001\/jamaophthalmol.2018.2189","article-title":"Association of macular and peripheral retinal macro-pseudocysts with chronic retinal detachment","volume":"136","author":"Liu","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1177\/11206721211012848","article-title":"Retinotomy and retinectomy for anterior inferior proliferative vitreoretinopathy: can visual outcome be improved","volume":"32","author":"Hocaoglu","year":"2022","journal-title":"Eur J Ophthalmol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1001\/archopht.1979.01020020015003","article-title":"Intraretinal macrocysts in retinal detachment","volume":"97","author":"Marcus","year":"1979","journal-title":"Arch Ophthalmol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4103\/0974-620X.192309","article-title":"Ultrawide field imaging of multiple intraretinal cysts in old rhegmatogenous retinal detachment","volume":"9","author":"Kumar","year":"2016","journal-title":"Oman J Ophthalmol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1051181\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T06:41:53Z","timestamp":1671086513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1051181\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":15,"alternative-id":["10.3389\/fmed.2022.1051181"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1051181","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]},"article-number":"1051181"}}