{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:25:05Z","timestamp":1764937505471,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Determining the cause of intrauterine fetal death is essential for patients to manage their next pregnancy. However, in the majority of cases of fetal death, the cause remains unexplained despite comprehensive evaluation, especially in the cases of twins. Among twin pregnancies, conditions of monochorionic twinning, commonly regarded as monozygotic, are more complicated than dichorionic ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>We systematically evaluated the cause of fetal death for a Han Chinese woman with monochorionic twinning following <jats:italic>in vitro<\/jats:italic> fertilization\/embryo transfer. Discrepant karyotypes were unexpectedly discovered between the twins. One fetus had an aneuploid male karyotype (46, XY), dup (9) (p24.3-q13), and the other had a normal female karyotype (46, XX). We considered that the male died of aberration of chromosome 9 and the female died of subsequent acute exsanguination through vascular anastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated the importance of recognizing the presence of monochorionic dizygotic twinning and the challenges of clinical management for twins following <jats:italic>in vitro<\/jats:italic> fertilization\/double embryo transfer.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.1055275","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T15:35:49Z","timestamp":1672846549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Determining the cause of intrauterine fetal death in monochorionic twins: A case report"],"prefix":"10.3389","volume":"9","author":[{"given":"Anxia","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuecheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/01.AOG","article-title":"Fetal death.","volume":"109","author":"Silver","year":"2007","journal-title":"Obstet Gynecol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3080","article-title":"Risk of recurrent stillbirth: systematic review and meta-analysis.","volume":"350","author":"Lamont","year":"2015","journal-title":"BMJ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1001\/jama.2011.1823","article-title":"Causes of death among stillbirths.","volume":"306","year":"2011","journal-title":"JAMA."},{"key":"B4","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0140-6736(15)01020-X","article-title":"Stillbirths: recall to action in high-income countries.","volume":"387","author":"Flenady","year":"2016","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.bpobgyn.2016.08.002","article-title":"Screening and prevention of stillbirth.","volume":"38","author":"Smith","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1093\/humrep\/deq045","article-title":"Mothers of IVF and spontaneously conceived twins: a comparison of prenatal maternal expectations, coping resources and maternal stress.","volume":"25","author":"Baor","year":"2010","journal-title":"Hum Reprod."},{"key":"B7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bpobgyn.2013.11.005","article-title":"Reducing multiple births in assisted reproduction technology.","volume":"28","author":"Bhattacharya","year":"2014","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4353","article-title":"Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis.","volume":"354","author":"Cheong-See","year":"2016","journal-title":"BMJ."},{"key":"B9","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1002\/uog.21973","article-title":"Monochorionic twins after in-vitro fertilization: do they have poorer outcomes? A retrospective cohort study.","volume":"56","author":"Couck","year":"2020","journal-title":"Ultrasound Obstet Gynecol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0140-6736(03)14237-7","article-title":"Twinning.","volume":"362","author":"Hall","year":"2003","journal-title":"Lancet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies.","volume":"26","author":"Manichaikul","year":"2010","journal-title":"Bioinformatics."},{"key":"B12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.tcb.2021.07.008","article-title":"Human embryonic development: from peri-implantation to gastrulation.","volume":"32","author":"Zhai","year":"2022","journal-title":"Trends Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.744890","article-title":"Case report: identification of germline chimerism in monochorionic dizygotic twins.","volume":"12","author":"Chen","year":"2021","journal-title":"Front Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1056\/NEJMoa030050","article-title":"Report of dizygous monochorionic twins.","volume":"349","author":"Souter","year":"2003","journal-title":"N Engl J Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/uog.22073","article-title":"Twin Anemia\u2013Polycythemia sequence in sex discordant monochorionic dizygotic twins.","volume":"56","author":"Chen","year":"2020","journal-title":"Ultrasound Obstet Gynecol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.bpobgyn.2013.12.010","article-title":"Prenatal screening and diagnosis of aneuploidy in multiple pregnancies.","volume":"28","author":"Gagnon","year":"2014","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/s1695-4033(04)78398-8","article-title":"Trisom\u00eda 9p.","volume":"61","author":"San Rom\u00e1n Mu\u00f1oz","year":"2004","journal-title":"An Pediatr (Barc)."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e473","DOI":"10.5546\/aap.2019","article-title":"Trisomy 9p. A brief clinical, diagnostic and therapeutic description.","volume":"117","author":"Cammarata-Scalisi","year":"2019","journal-title":"Arch Argent Pediatr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3343\/kjlm.2008.28.2.155","article-title":"A case of partial trisomy 9pter \u2013> q13 due to paternal balanced translocation t (9;21) (q13;q21).","volume":"28","author":"Woo","year":"2008","journal-title":"Korean J Lab Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1515\/jpm-2012-0019","article-title":"Single fetal death in twin gestations.","volume":"41","author":"Blickstein","year":"2013","journal-title":"J Perinat Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bpobgyn","article-title":"Single-twin demise: pregnancy outcome.","volume":"28","author":"Shek","year":"2014","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10038-004-0216-6","article-title":"Do monochorionic dizygotic twins increase after pregnancy by assisted reproductive technology?","volume":"50","author":"Miura","year":"2005","journal-title":"J Hum Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s10815-013-0109-8","article-title":"Testicular hypoplasia in monochorionic dizygous twin with confined blood chimerism.","volume":"30","author":"Choi","year":"2013","journal-title":"J Assist Reprod Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3760\/cma.j.issn.1003-9406.2013.03.024","article-title":"Prevalence of chromosome 9 abnormalities among pediatric specimens.","volume":"30","author":"Wang","year":"2013","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41436-018-0298-8","article-title":"Molecular autopsy by trio exome sequencing (ES) and postmortem examination in fetuses and neonates with prenatally identified structural anomalies.","volume":"21","author":"Quinlan-Jones","year":"2019","journal-title":"Genet Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"B2","DOI":"10.1016\/j.ajog","article-title":"Obstetric care consensus #10: management of stillbirth: (replaces practice bulletin number 102, March 2009).","volume":"222","year":"2020","journal-title":"Am J Obstet Gynecol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1055275\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T15:35:53Z","timestamp":1672846553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1055275\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":26,"alternative-id":["10.3389\/fmed.2022.1055275"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1055275","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"article-number":"1055275"}}