{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:05:59Z","timestamp":1787065559843,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Genomic analysis of hepatitis B virus (HBV) identifies phylogenetic variants, which may lead to distinct biological and clinical behaviors. The satellite hepatitis D virus (HDV) may also influence clinical outcomes in patients with hepatitis B. The aim of this study was to investigate HBV genetic variants, including clinically relevant mutations, and HDV infection in acute and chronic hepatitis B patients in central Argentina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 217 adult HBV infected patients [acute (AHB):\n                      <jats:italic>n<\/jats:italic>\n                      = 79; chronic (CHB):\n                      <jats:italic>n<\/jats:italic>\n                      = 138] were studied; 67 were HBV\/human immunodeficiency virus (HIV) coinfected. Clinical and demographic data were obtained from medical records. Serological markers were determined. Molecular detection of HBV and HDV was carried out by RT-Nested PCR, followed by sequencing and phylogenetic analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, genotype (gt) F [sub-genotype (sgt) F1b] was the most frequently found. In AHB patients, the gts\/sgts found were: F1b (74.7%) &amp;gt; A2 (13.9%) &amp;gt; F4 (7.6%) &amp;gt; C (2.5%) &amp;gt; A1 (1.3%). Among CHB patients: F1b (39.1%) &amp;gt; A2 (23.9%) &amp;gt; F4 (18.2%) &amp;gt; D (9.4%) &amp;gt; C and F6 (3.6% each) &amp;gt; A1, A3 and B2 (0.7% each). The distribution of sgt A2 and gt D was significantly different between HBV mono and HBV\/HIV coinfected patients [A2: 15.9% vs. 35.7% (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), respectively and D: 14.6% vs. 1.8% (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), respectively]. Mutation frequency in basal core promoter\/pre-Core (BCP\/pC) region was 35.5% (77\/217) [AHB: 20.3% (16\/79), CHB: 44.2% (61\/138)]. In the open reading frame (ORF) S, mutations associated with vaccine escape and diagnostic failure were detected in 7.8% of the sequences (17\/217) [AHB: 3.8% (3\/79), CHB: 10.1% (14\/138)]. ORF-P amino acid substitutions associated with antiviral resistance were detected in 3.2% of the samples (7\/217) [AHB: 1.3% (1\/79), CHB 4.3%, (6\/138)]. The anti-HDV seropositivity was 5.2% (4\/77); one sample could be sequenced, belonging to gt HDV-1 associated with sgt HBV-D3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We detected an increase in the circulation of genotype F in Central Argentina, particularly among AHB patients, suggesting transmission advantages over the other genotypes. A low rate of mutations was detected, especially those with antiviral resistance implications, which is an encouraging result. The evidence of HDV circulation in our region, reported for the first time, alerts the health system for its search and diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2022.1057194","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T04:14:55Z","timestamp":1673237695000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV"],"prefix":"10.3389","volume":"9","author":[{"given":"Gonzalo M.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola E.","family":"Sicilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda I.","family":"Riberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"Debes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Barb\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda E.","family":"Cudol\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda B.","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana E.","family":"R\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"B1","year":"2022","journal-title":"Home\/Newsroom\/Fact sheets\/Detail\/Hepatitis B."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1128\/CMR.00046-19","article-title":"Hepatitis B virus: advances in prevention, diagnosis, and therapy.","volume":"33","author":"Nguyen","year":"2020","journal-title":"Clin Microbiol Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41575-020-0296-6","article-title":"The evolution and clinical impact of hepatitis B virus genome diversity.","volume":"17","author":"Revill","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.clinre.2020.04.018","article-title":"B virus American genotypes: pathogenic variants?","volume":"44","author":"Pujol","year":"2020","journal-title":"Clin Res Hepatol Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1002\/jmv.21309","article-title":"Change of hepatitis B virus genotypes in acute and chronic infections in Japan.","volume":"80","author":"Kobayashi","year":"2008","journal-title":"J Med Virol."},{"key":"B6","first-page":"137","article-title":"The impact of viral molecular diversity on the clinical presentation and outcome of acute hepatitis B in Italy.","volume":"38","author":"Sagnelli","year":"2015","journal-title":"New Microbiol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.17126","article-title":"Correlation between hepatitis B G1896A precore mutations and HBeAg in chronic HBV patients.","volume":"8","author":"Zhand","year":"2015","journal-title":"Jundishapur J Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1111\/j.1572-0241.2008.01974.x","article-title":"HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study.","volume":"103","author":"Fang","year":"2008","journal-title":"Am J Gastroenterol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/hep.21249","article-title":"Influence of genotypes and preCore mutations on fulminant or chronic outcome of acute hepatitis B virus infection.","volume":"44","author":"Ozasa","year":"2006","journal-title":"Hepatology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jcv.2018.01.011","article-title":"Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: reliable detection of HBV by the elecsys HBsAg II assay.","volume":"101","author":"Gencay","year":"2018","journal-title":"J Clin Virol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167871","article-title":"Investigation of a novel hepatitis B virus surface antigen (HBsAg) escape mutant affecting immunogenicity.","volume":"12","author":"Hossain","year":"2017","journal-title":"PLoS One."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.37806","article-title":"Genotyping and mutation pattern in the overlapping MHR region of HBV isolates in Southern Khorasan.","volume":"16","author":"Ziaee","year":"2016","journal-title":"Eastern Iran. Hepat Mon"},{"key":"B13","year":"2022","journal-title":"Home\/Newsroom\/Fact sheets\/Detail\/Hepatitis D."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-017-0845-y","article-title":"Hepatitis delta: virological and clinical aspects.","volume":"14","author":"Botelho-Souza","year":"2017","journal-title":"Virol J"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/life11020169","article-title":"HBV\/HDV co-infection: epidemiological and clinical changes. recent knowledge and future challenges.","volume":"11","author":"Sagnelli","year":"2021","journal-title":"Life."},{"key":"B16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.actatropica.2008.02.009","article-title":"Hepatitis D and B virus genotypes in chronically infected patients from the Eastern Amazon Basin.","volume":"106","author":"Gomes-Gouv\u00eaa","year":"2008","journal-title":"Acta Trop."},{"key":"B17","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/MEG.0000000000000007","article-title":"Hepatitis delta virus genotype-1 alone cocirculates with hepatitis B virus genotypes A and D in Pakistan.","volume":"26","author":"Butt","year":"2014","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1469-0691.2010.03283.x","article-title":"Hepatitis B virus in Buenos Aires, Argentina: genotypes, virological characteristics and clinical outcomes.","volume":"17","author":"Pezzano","year":"2011","journal-title":"Clin Microbiol Infect."},{"key":"B19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jcv.2014.06.030","article-title":"Molecular epidemiology of Hepatitis B virus in C\u00f3rdoba, Argentina.","volume":"61","author":"Gallego","year":"2014","journal-title":"J Clin Virol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1007\/s00705-016-2960-2","article-title":"Hepatitis B virus infection in blood donors in Argentina: prevalence of infection, genotype distribution and frequency of occult HBV infection.","volume":"161","author":"Pisano","year":"2016","journal-title":"Arch Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1128\/JCM.36.11.3362-3365","article-title":"Distribution of hepatitis B virus genotypes in two different pediatric populations from Argentina.","volume":"36","author":"Mbayed","year":"1998","journal-title":"J Clin Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00705-013-1917-y","article-title":"Hepatitis B virus and hepatitis D virus in blood donors from Argentina: circulation of HBsAg and reverse transcriptase mutants.","volume":"159","author":"Delfino","year":"2014","journal-title":"Arch Virol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-131","article-title":"Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients.","volume":"9","author":"Barbini","year":"2012","journal-title":"Virol J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.meegid.2013.07.007","article-title":"Molecular epidemiology and genetic diversity of hepatitis B virus in Mar del Plata city, Argentina.","volume":"19","author":"Barbini","year":"2013","journal-title":"Infect Genet Evol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/jvh.13052","article-title":"Molecular epidemiology of hepatitis B virus mutants associated with vaccine escape, drug resistance and diagnosis failure.","volume":"26","author":"Di Lello","year":"2019","journal-title":"J Viral Hepat."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159509","article-title":"Analysis of the molecular evolution of hepatitis B virus genotypes in symptomatic acute infections in Argentina.","volume":"11","author":"Rodrigo","year":"2016","journal-title":"PLoS One."},{"key":"B27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.meegid.2016.11.023","article-title":"New pieces on genetic diversity and evolutionary history of hepatitis B virus: characterization of the novel subgenotype F6.","volume":"47","author":"Mojsiejczuk","year":"2017","journal-title":"Infect Genet Evol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jcv.2012.04.014","article-title":"HDAg-L variants in covert hepatitis D and HBV occult infection among Amerindians of Argentina: new insights.","volume":"54","author":"Delfino","year":"2012","journal-title":"J Clin Virol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0.","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol Biol Evol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2109","article-title":"jModelTest2: more models, new heuristics and parallel computing.","volume":"9","author":"Darriba","year":"2012","journal-title":"Nat Methods."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-62","article-title":"Mutation reporter tool: an online tool to interrogate loci of interest, with its utility demonstrated using hepatitis B virus.","volume":"10","author":"Bell","year":"2013","journal-title":"Virol J."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.616023","article-title":"comprehensive analysis of clinically significant hepatitis B virus mutations in relation to genotype, subgenotype and geographic region.","volume":"11","author":"Araujo","year":"2020","journal-title":"Front Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3851\/IMP2599","article-title":"Distribution of HBV genotypes in Latin America.","volume":"18","author":"Alvarado-Mora","year":"2013","journal-title":"Antivir Ther."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104294","article-title":"Tracing back hepatitis B virus genotype D introduction and dissemination in South Brazil.","volume":"82","author":"Wolf","year":"2020","journal-title":"Infect Genet Evol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jcv.2008.01.018","article-title":"Hepatitis B virus genetic diversity in Argentina: dissimilar genotype distribution in two different geographical regions; description of hepatitis B surface antigen variants.","volume":"42","author":"Pi\u00f1eiro","year":"2008","journal-title":"J Clin Virol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.meegid.2019.03.020","article-title":"Molecular epidemiology of hepatitis B virus in Paraguay.","volume":"71","author":"Mojsiejczuk","year":"2019","journal-title":"Infect Genet Evol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.meegid.2015.03.009","article-title":"Reliable timescale inference of HBV genotype A origin and phylodynamics.","volume":"32","author":"Zehender","year":"2015","journal-title":"Infect Genet Evol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/jvh.13527","article-title":"Temporal and geographic spreading of hepatitis B virus genotype A (HBV-A) in Brazil and the Americas.","volume":"28","author":"Wolf","year":"2021","journal-title":"J Viral Hepat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jhep.2009.12.014","article-title":"Is response to antiviral treatment influenced by hepatitis B virus genotype?","volume":"52","author":"Raimondi","year":"2010","journal-title":"J Hepatol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220342","article-title":"Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas.","volume":"14","author":"Spitz","year":"2019","journal-title":"PLoS One."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104973","article-title":"HBV evolution and genetic variability: impact on prevention, treatment and development of antivirals.","volume":"186","author":"Glebe","year":"2021","journal-title":"Antiviral Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2021.100574","article-title":"Hepatitis B virus genotypes and subgenotypes and the natural history and epidemiology of hepatitis B.","author":"Reuter","year":"2022","journal-title":"Ann Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"708","DOI":"10.4254\/wjh.v14.i4.708","article-title":"Review on hepatitis B virus preCore\/core promoter mutations and their correlation with genotypes and liver disease severity.","volume":"14","author":"Kumar","year":"2022","journal-title":"World J Hepatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.virusres.2007.02.021","article-title":"Hepatitis B virus genetic variability and evolution.","volume":"127","author":"Kay","year":"2007","journal-title":"Virus Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.meegid.2015.08.024","article-title":"Hepatitis B virus intergenotypic recombinants worldwide: an overview.","volume":"36","author":"Araujo","year":"2015","journal-title":"Infect Genet Evol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7653","DOI":"10.3748\/wjg.v20.i24.7653","article-title":"Clinical implications of hepatitis B virus mutations: recent advances.","volume":"20","author":"Lazarevic","year":"2014","journal-title":"World J Gastroenterol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07085-z","article-title":"Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in Eastern China.","volume":"7","author":"Yan","year":"2017","journal-title":"Sci Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/jmv.20516","article-title":"Frequency of hepatitis B virus \u2018a\u2019 determinant variants in unselected spanish chronic carriers.","volume":"78","author":"Avell\u00f3n","year":"2006","journal-title":"J Med Virol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/jmv.23183","article-title":"Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.","volume":"84","author":"Ma","year":"2012","journal-title":"J Med Virol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4428-y","article-title":"Hepatitis B infection in the general population of China: a systematic review and meta-analysis.","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Infect Dis."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006629","article-title":"A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent action.","volume":"12","author":"Mokaya","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00234-14","article-title":"Commonly found variations\/mutations in the HBsAg of hepatitis B virus in the context of effective immunization programs: questionable clinical and public health significance.","volume":"88","author":"Locarnini","year":"2014","journal-title":"J Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1128\/JVI.03654-13","article-title":"Viral hepatitis prevention board. reduced prevalence of HBsAg variants following a successful immunization program in China.","volume":"88","author":"Jilg","year":"2014","journal-title":"J Virol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1128\/JVI.70.9.5845-5851.1996","article-title":"Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on preCore gene expression and viral replication.","volume":"70","author":"Buckwold","year":"1996","journal-title":"J Virol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1086\/596655","article-title":"Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B.","volume":"199","author":"Liu","year":"2009","journal-title":"J Infect Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jhep.2011.11.012","article-title":"Quantitative dynamics of hepatitis B basal core promoter and preCore mutants before and after HBeAg seroconversion.","volume":"56","author":"Nie","year":"2012","journal-title":"J Hepatol."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121436","article-title":"Hepatitis B virus genotype distribution and genotype-specific BCP\/preCore substitutions in acute and chronic infections in Argentina.","volume":"10","author":"Gonz\u00e1lez L\u00f3pez Ledesma","year":"2015","journal-title":"PLoS One."},{"key":"B58","year":"2021","journal-title":"SAHE - Sociedad argentina de hepatolog\u00eda."},{"key":"B59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/978-981-13-9151-4_6","article-title":"Present and future therapies for chronic hepatitis B.","volume":"1179","author":"Tao","year":"2020","journal-title":"Adv Exp Med Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.coviro.2013.08.006","article-title":"Hepatitis B antivirals and resistance.","volume":"3","author":"Devi","year":"2013","journal-title":"Curr Opin Virol."},{"key":"B61","year":"2022","journal-title":"Coverage Immunization."},{"key":"B62","year":"2016","journal-title":"Global health sector strategy on viral hepatitis 2016-2021. Towards ending viral hepatitis."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1057194\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T04:14:59Z","timestamp":1673237699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1057194\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,9]]},"references-count":62,"alternative-id":["10.3389\/fmed.2022.1057194"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1057194","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,9]]},"article-number":"1057194"}}