{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:08Z","timestamp":1789759448702,"version":"4.0.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Immune-mediated alopecias (IMAs), a group of hair disorders associated with immunological reactions, remain a therapeutic challenge since available treatments are generally unfavorable with potential side effects. Platelet-rich plasma (PRP) has been recently proposed as a treatment option based on several limited-quality studies; however, there is no systematic evaluation of PRP efficacy on IMAs in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess PRP\u2019s effects in treating IMAs using a systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches were conducted using PubMed, Embase, Scopus, and Cochrane Library databases. A search strategy was designed to retrieve all studies exploring PRP in treating IMAs, including alopecia areata (AA) and primary cicatricial alopecias (PCAs). In addition, all randomized and non-randomized studies reporting subjective and\/or objective outcomes of alopecia treatment with PRP were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty-two studies were included, comprising 621 patients with AA and 19 patients with PCAs. PRP had superior efficacy as monotherapy in five studies, comparable to intralesional corticosteroids in six studies in AA treatment. In addition, in the analysis of PCAs, including lymphocytic and neutrophilic subtypes, PRP was efficacious in alleviating disease progression in nine studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PRP is considered a promising treatment for AA and PCAs in patients who experienced unfavorable outcomes from conventional treatment. However, its clinical application remains to be standardized, and its recommendation as a treatment for IMAs could not be ascertained due to a lack of high-quality evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>[<jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=353859<\/jats:ext-link>], identifier [CRD42022353859].<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.1058431","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:20:52Z","timestamp":1669270852000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Platelet-rich plasma in alopecia areata and primary cicatricial alopecias: A systematic review"],"prefix":"10.3389","volume":"9","author":[{"given":"Kasama","family":"Tejapira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanat","family":"Yongpisarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawara","family":"Sakpuwadol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonkiat","family":"Suchonwanit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.2147\/ppa.S282399","article-title":"Measuring patient quality of life following treatment for alopecia.","volume":"15","author":"Thadanipon","year":"2021","journal-title":"Patient Prefer Adherence."},{"key":"B2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.2147\/ccid.S247390","article-title":"Asian hair: a review of structures, properties, and distinctive disorders.","volume":"13","author":"Leerunyakul","year":"2020","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2501248","article-title":"PPAR-\u03b3 agonists and their role in primary cicatricial alopecia.","volume":"2017","author":"Harnchoowong","year":"2017","journal-title":"PPAR Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.2147\/dddt.S240615","article-title":"Finasteride and its potential for the treatment of female pattern hair loss: evidence to date.","volume":"14","author":"Iamsumang","year":"2020","journal-title":"Drug Des Devel Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s40257-018-0378-1","article-title":"Alopecia in association with malignancy: a review.","volume":"19","author":"Suchonwanit","year":"2018","journal-title":"Am J Clin Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1016\/j.jisp.2017.10.014","article-title":"Hair follicle immune privilege revisited: the key to alopecia areata management.","volume":"19","author":"Paus","year":"2018","journal-title":"J Investig Dermatol Symp Proc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000518434","article-title":"Variation of hair follicle counts among different scalp areas: a quantitative histopathological study.","volume":"8","author":"Rutnin","year":"2022","journal-title":"Skin Appendage Disord."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/253154","article-title":"Leprosy reaction in thai population: a 20-year retrospective study.","volume":"2015","author":"Suchonwanit","year":"2015","journal-title":"Dermatol Res Pract."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2476890","article-title":"Evaluation of hair density and hair diameter in the adult thai population using quantitative trichoscopic analysis.","volume":"2020","author":"Leerunyakul","year":"2020","journal-title":"Biomed Res Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2147\/itt.S266409","article-title":"Alopecia areata: an autoimmune disease of multiple players.","volume":"10","author":"Suchonwanit","year":"2021","journal-title":"Immunotargets Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.2147\/jir.S331579","article-title":"Prevalence and risk factors associated with the occurrence of autoimmune diseases in patients with alopecia areata.","volume":"14","author":"Chanprapaph","year":"2021","journal-title":"J Inflamm Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/ijd.13453","article-title":"Trichoscopic clues for diagnosis of alopecia areata and trichotillomania in Asians.","volume":"56","author":"Khunkhet","year":"2017","journal-title":"Int J Dermatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2017.04.1141","article-title":"Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis.","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J Am Acad Dermatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1111\/ijd.13061","article-title":"Factors affecting the severity of central centrifugal cicatricial alopecia.","volume":"55","author":"Suchonwanit","year":"2016","journal-title":"Int J Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1159\/000503681","article-title":"Fibrosing alopecia in a pattern distribution: a case report and literature review.","volume":"11","author":"Triyangkulsri","year":"2019","journal-title":"Case Rep Dermatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.2353\/ajpath.2010.100454","article-title":"The pathogenesis of primary cicatricial alopecias.","volume":"177","author":"Harries","year":"2010","journal-title":"Am J Pathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/ijd.14672","article-title":"Frontal fibrosing alopecia in Asians: a retrospective clinical study.","volume":"59","author":"Suchonwanit","year":"2020","journal-title":"Int J Dermatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2147\/dddt.S342179","article-title":"Intramuscular corticosteroid therapy in the treatment of alopecia areata: a time-to-event analysis.","volume":"16","author":"Chanprapaph","year":"2022","journal-title":"Drug Des Devel Ther."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.2147\/dddt.S297858","article-title":"Application of topical immunotherapy in the treatment of alopecia areata: a review and update.","volume":"15","author":"Mahasaksiri","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2017.7399","article-title":"A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata.","volume":"9","author":"Sriphojanart","year":"2017","journal-title":"Dermatol Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1080\/09546634.2020.1773384","article-title":"A comparison of the efficacy and tolerability of three corticosteroid treatment regimens in patients with alopecia areata.","volume":"33","author":"Suchonwanit","year":"2022","journal-title":"J Dermatolog Treat."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.2147\/dddt.S172638","article-title":"Role of janus kinase inhibitors in the treatment of alopecia areata.","volume":"12","author":"Triyangkulsri","year":"2018","journal-title":"Drug Des Devel Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/14656566.2020.1854728","article-title":"Are drug treatment strategies really effective against alopecia areata?","volume":"22","author":"Rattananukrom","year":"2021","journal-title":"Expert Opin Pharmacother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jaad.2020.03.004","article-title":"The Alopecia Areata Consensus of Experts (ACE) study: results of an international expert opinion on treatments for alopecia areata.","volume":"83","author":"Meah","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jaad.2017.04.1142","article-title":"Alopecia areata: an appraisal of new treatment approaches and overview of current therapies.","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J Am Acad Dermatol."},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1111\/j.1524-4725.2012.02394.x","article-title":"Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth.","volume":"38","author":"Li","year":"2012","journal-title":"Dermatol Surg."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207794","article-title":"Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020.","volume":"21","author":"Everts","year":"2020","journal-title":"Int J Mol Sci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13650","article-title":"Diagnostic and prognostic values of cutaneous manifestations in COVID-19.","volume":"33","author":"Suchonwanit","year":"2020","journal-title":"Dermatol Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/j.1600-051X.2006.00991.x","article-title":"Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes.","volume":"33","author":"Christgau","year":"2006","journal-title":"J Clin Periodontol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"Bmj."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions.","volume":"355","author":"Sterne","year":"2016","journal-title":"Bmj."},{"key":"B32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments.","volume":"12","author":"McGuinness","year":"2020","journal-title":"Res Synth Methods."},{"key":"B33","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/bjd.12397","article-title":"A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata.","volume":"169","author":"Trink","year":"2013","journal-title":"Br J Dermatol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12437","article-title":"Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: a trichoscopic evaluation.","volume":"30","author":"El Taieb","year":"2017","journal-title":"Dermatol Ther."},{"key":"B35","first-page":"59","article-title":"Safety and efficacy of microneedling with autologous platelet-rich plasma in chronic and stable alopecia areata.","volume":"28","author":"Nagaratna","year":"2018","journal-title":"J Pak Assoc Dermatol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12989","article-title":"The effect of platelet rich plasma on hair regrowth in patients with alopecia areata totalis: a clinical pilot study.","volume":"32","author":"Khademi","year":"2019","journal-title":"Dermatol Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1111\/jocd.12858","article-title":"Evaluation of platelet-rich plasma vs intralesional steroid in treatment of alopecia areata.","volume":"18","author":"Albalat","year":"2019","journal-title":"J Cosmetic Dermatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.15570\/actaapa.2020.35","article-title":"Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or microneedling.","volume":"25","author":"Ragab","year":"2020","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/jcas.Jcas_16_19","article-title":"Comparative evaluation of therapeutic efficacy of intralesional injection of triamcinolone acetonide versus intralesional autologous platelet-rich plasma injection in alopecia areata.","volume":"13","author":"Kapoor","year":"2020","journal-title":"J Cutan Aesthet Surg."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14388","article-title":"A randomized, placebo and active controlled, split scalp study to evaluate the efficacy of platelet-rich plasma in patchy alopecia areata of the scalp.","volume":"33","author":"Hegde","year":"2020","journal-title":"Dermatol Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"920","DOI":"10.4103\/idoj.IDOJ_6_20","article-title":"A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata.","volume":"11","author":"Balakrishnan","year":"2020","journal-title":"Indian Dermatol Online J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.jaad.2020.12.039","article-title":"Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: a randomized observer-blinded, placebo-controlled, split-head pilot study.","volume":"84","author":"Gupta","year":"2021","journal-title":"J Am Acad Dermatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3889\/oamjms.2022.7428","article-title":"Low level laser versus platelet-rich plasma in treatment of alopecia areata: a randomized controlled intra-patient comparative study.","volume":"10","author":"Tawfik","year":"2022","journal-title":"Open Access Macedonian J Med Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/0970-0358.155271","article-title":"Role of platelet-rich plasma in chronic alopecia areata: our centre experience.","volume":"48","author":"Singh","year":"2015","journal-title":"Indian J Plastic Surg."},{"key":"B45","first-page":"107","article-title":"Role of autologous platelet rich plasma (PRP) in limited alopecia areata in local population.","volume":"26","author":"Khan","year":"2016","journal-title":"J Pak Assoc Dermatol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/01.EWX.0000540042.97989.cf","article-title":"Evaluation of platelet-rich plasma in treatment of alopecia areata: a placebo-controlled study.","volume":"15","author":"Fayed","year":"2018","journal-title":"J Egypt Women\u2019s Dermatol Soc."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1111\/jocd.13739","article-title":"Trichoscopy as an evaluation method for alopecia areata treatment: a comparative study.","volume":"20","author":"Fawzy","year":"2021","journal-title":"J Cosmetic Dermatol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jdcr.2015.07.004","article-title":"Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP).","volume":"1","author":"Donovan","year":"2015","journal-title":"JAAD Case Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jdds.2015.11.002","article-title":"Platelet-rich plasma combined with intralesional triamcinolone acetonide for the treatment of alopecia areata: a case report.","volume":"20","author":"Mubki","year":"2016","journal-title":"J Dermatol Dermatol Surg."},{"key":"B50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.5935\/scd1984-8773.2016831504","article-title":"Use of platelet-rich plasma in the treatment of difficult-to-control alopecia areata.","volume":"8","author":"De Vasconcelos","year":"2016","journal-title":"Surg Cosmetic Dermatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2478\/sjdv-2019-0007","article-title":"Successful management of treatment-resistant alopecia areata with platelet rich plasma: a case series.","volume":"11","author":"Fonseka","year":"2019","journal-title":"Serbian J Dermatol Venereol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13082","article-title":"Steroid-resistant alopecia totalis in a child successfully treated with oral apremilast and platelet-rich plasma therapy.","volume":"32","author":"Chhabra","year":"2019","journal-title":"Dermatol Ther."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7495","article-title":"Successful treatment of alopecia areata barbae with platelet-rich plasma.","volume":"12","author":"Pototschnig","year":"2020","journal-title":"Cureus."},{"key":"B54","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1016\/j.jisp.2020.05.008","article-title":"Monitoring response to platelet-rich plasma in patients with alopecia areata with optical coherence tomography: a case series.","volume":"20","author":"Ekelem","year":"2020","journal-title":"J Investig Dermatol Symp Proc."},{"key":"B55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jdcr.2021.11.019","article-title":"Clinical response to adjunctive platelet-rich plasma injections in a patient with alopecia universalis on oral tofacitinib.","volume":"20","author":"Ederaine","year":"2022","journal-title":"JAAD Case Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/dth.12343","article-title":"Platelet-rich plasma as a novel treatment for lichen planopillaris.","volume":"29","author":"Bolan\u010da","year":"2016","journal-title":"Dermatol Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1016\/j.jaad.2018.05.029","article-title":"Platelet-rich plasma for the treatment of lichen planopilaris.","volume":"79","author":"Jha","year":"2018","journal-title":"J Am Acad Dermatol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13072","article-title":"Platelet-rich plasma for treatment resistant frontal fibrosing alopecia: a case report.","volume":"32","author":"\u00d6zcan","year":"2019","journal-title":"Dermatol Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1016\/j.jaad.2018.09.013","article-title":"Platelet-rich plasma as an adjunctive treatment in lichen planopilaris.","volume":"80","author":"Jha","year":"2019","journal-title":"J Am Acad Dermatol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/DSS.0000000000001635","article-title":"Use of platelet-rich plasma in cicatricial alopecia.","volume":"45","author":"Dina","year":"2019","journal-title":"Dermatol Surg."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.jaad.2020.06.026","article-title":"Use of platelet-rich plasma in lichen planopilaris and its variants: a retrospective case series demonstrating treatment tolerability without koebnerization.","volume":"83","author":"Svigos","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jdcr.2021.04.008","article-title":"The role of platelet-rich plasma therapy in refractory folliculitis decalvans.","volume":"12","author":"Suh","year":"2021","journal-title":"JAAD Case Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"309","DOI":"10.36849\/jdd.5933","article-title":"Platelet rich plasma for the treatment of scarring alopecia due to discoid lupus erythematosus.","volume":"21","author":"Polster","year":"2022","journal-title":"J Drugs Dermatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"671","DOI":"10.36849\/jdd.6810","article-title":"Reversible hair loss in lichen planopilaris: regrowth with low-dose naltrexone and platelet-rich plasma.","volume":"21","author":"Klein","year":"2022","journal-title":"J Drugs Dermatol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yexcr.2017.02.012","article-title":"Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage.","volume":"352","author":"Moussa","year":"2017","journal-title":"Exp Cell Res."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5128376","article-title":"Assessing biophysical and physiological profiles of scalp seborrheic dermatitis in the thai population.","volume":"2019","author":"Suchonwanit","year":"2019","journal-title":"Biomed Res Int."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1268430","article-title":"Scalp pruritus: review of the pathogenesis, diagnosis, and management.","volume":"2019","author":"Rattanakaemakorn","year":"2019","journal-title":"Biomed Res Int."},{"key":"B68","doi-asserted-by":"publisher","first-page":"781","DOI":"10.2147\/cia.S310178","article-title":"Scalp biophysical characteristics in males with androgenetic alopecia: a comparative study with healthy controls.","volume":"16","author":"Chanprapaph","year":"2021","journal-title":"Clin Interv Aging."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1177\/2059513118808773","article-title":"The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review.","volume":"4","author":"Alser","year":"2018","journal-title":"Scars Burn Heal."},{"key":"B70","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/09546634.2020.1782324","article-title":"Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature.","volume":"33","author":"Suchonwanit","year":"2022","journal-title":"J Dermatol Treat."},{"key":"B71","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/dss.0000000000001614","article-title":"Platelet-rich plasma augments subcision in atrophic acne scars: a split-face comparative study.","volume":"45","author":"Deshmukh","year":"2019","journal-title":"Dermatol Surg."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.890206","article-title":"Epidemiological, clinical, and trichoscopic features of syphilitic alopecia: a retrospective analysis and systematic review.","volume":"9","author":"Pomsoong","year":"2022","journal-title":"Front Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/dss.0000000000001965","article-title":"Platelet-rich plasma and its utilities in alopecia: a systematic review.","volume":"46","author":"Hesseler","year":"2020","journal-title":"Dermatol Surg."},{"key":"B74","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jaad.2018.09.033","article-title":"Treatment of male pattern alopecia with platelet-rich plasma: a double-blind controlled study with analysis of platelet number and growth factor levels.","volume":"80","author":"Rodrigues","year":"2019","journal-title":"J Am Acad Dermatol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1058431\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:20:56Z","timestamp":1669270856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1058431\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":74,"alternative-id":["10.3389\/fmed.2022.1058431"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1058431","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"article-number":"1058431"}}