{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:23:26Z","timestamp":1787243006149,"version":"build-2736575974"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Generalized pustular psoriasis (GPP) is a rare and severe form of psoriasis presenting with erythematous, aseptic pustules. Common systemic symptoms include fever and myalgias. The presentation of GPP resembles acute generalized exanthematous pustulosis (AGEP). However, the treatment of these two pathologies differs. While AGEP is self-limiting and treated with topical corticosteroids and constrain of systemic steroids. GPP treatment avoids corticosteroid, choosing acitretin, methotrexate, and cyclosporine as first-line agents. In this case report, a 27-year-old female with a medical history of AGEP presented to the hospital with extensive erythema and pustules. Complete blood count acute phase reactant analysis revealed an elevated white blood cell count and C-reactive protein (CRP). Two histopathological examinations revealed psoriatic hyperplasia of the epidermis with keratosis, along with Kogoj and Munro micro abscesses above the spina layer. Lymphocytic and neutrophilic infiltrate was present in the superficial derma layer along with vasodilation. The patient was diagnosed with GPP according to pathological and clinical criteria. Treatment was initiated with secukinumab because of the patient\u2019s failure to respond to systemic treatment with Acitretin, methotrexate, and cyclosporin. Following 2 weeks of therapy with 300 mg of secukinumab, the pustular lesions had resolved. This study indicates the potential efficacy of secukinumab as an effective therapy that can rapidly improve the clinical symptoms of GPP.<\/jats:p>","DOI":"10.3389\/fmed.2022.1072039","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T06:53:44Z","timestamp":1670482424000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case report: Successful treatment of acute generalized pustular psoriasis of puerperium with secukinumab"],"prefix":"10.3389","volume":"9","author":[{"given":"Gao","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Lili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yimiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiaohong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Dongmei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"B1","first-page":"1464","article-title":"Update on acute generalized exanthematous pustulosis.","volume":"32","author":"He","year":"2018","journal-title":"Chin J Derm Venereol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2147\/PTT.S98954","article-title":"Pustular psoriasis: pathophysiology and current treatment perspectives.","volume":"6","author":"Benjegerdes","year":"2016","journal-title":"Psoriasis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/s0190-9622(87)70281-3","article-title":"Penicillin-induced generalized pustular psoriasis.","author":"Katz","year":"1987","journal-title":"J Am Acad Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1080\/09546634.2019.1682502","article-title":"Review of treatments for generalized pustular psoriasis.","volume":"32","author":"Kearns","year":"2020","journal-title":"J Dermatolog Treat."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1007\/s13555-021-00612-x","article-title":"Pustular psoriasis: a narrative review of recent developments in pathophysiology and therapeuticoptions.","volume":"11","author":"Mener","year":"2021","journal-title":"Dermatol Ther."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1080\/09546634.2022.2089335","article-title":"Generalized pustular psoriasis: the new era of treatment with IL-36 receptor inhibitors.","volume":"33","author":"Ma\u00e7\u00e3es","year":"2022","journal-title":"J Dermatolog Treat."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1111\/1346-8138.13306","article-title":"Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: a 52-week analysis from phase III open-label multicenter Japanese study.","volume":"43","author":"Imafuku","year":"2016","journal-title":"J Dermatol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16551","article-title":"Real-world data on the use of secukinumab and acitretin in pediatric generalized pustular psoriasis.","author":"Miao","year":"2022","journal-title":"J Dermatol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.04.064","article-title":"Real-world data on the clinical use of secukinumab in pediatric generalized pustular psoriasis: a 48-week retrospective study.","author":"Ruan","year":"2022","journal-title":"J Am Acad Dermatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/1346-8138.14523","article-title":"Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP.","volume":"45","author":"Fujita","year":"2018","journal-title":"J Dermatol."}],"container-title":["Frontiers in 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