{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:47Z","timestamp":1793059967436,"version":"4.5.0"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.<\/jats:p>","DOI":"10.3389\/fmed.2022.1093868","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:50:07Z","timestamp":1673916607000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["Trace element zinc and skin disorders"],"prefix":"10.3389","volume":"9","author":[{"given":"Pan","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/nu10020199","article-title":"Zinc and skin disorders","volume":"10","author":"Ogawa","year":"2018","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jphs.2021.11.007","article-title":"Zinc transporters as potential therapeutic targets: an updated review","volume":"148","author":"Hara","year":"2022","journal-title":"J Pharmacol Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.15761\/GOD.1000185","article-title":"An overview of zinc and its importance in dermatology-Part I: importance and function of zinc in human beings","volume":"3","author":"Bagherani","year":"2016","journal-title":"Glob Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu Rev Nutr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"709152","DOI":"10.1155\/2014\/709152","article-title":"Zinc therapy in dermatology: a review","volume":"2014","author":"Gupta","year":"2014","journal-title":"Dermatol Res Pract."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/aps.2018.25","article-title":"Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases","volume":"39","author":"Choi","year":"2018","journal-title":"Acta Pharmacol Sin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3945\/an.112.003210","article-title":"Discovery of human zinc deficiency: its impact on human health and disease","volume":"4","author":"Prasad","year":"2013","journal-title":"Adv Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s40257-017-0290-0","article-title":"Sunscreens: an update","volume":"18","author":"Mancuso","year":"2017","journal-title":"Am J Clin Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1056\/NEJM197504242921702","article-title":"Zinc therapy of acrodermatitis enteropathica","volume":"292","author":"Neldner","year":"1975","journal-title":"N Engl J Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1046\/j.1365-2133.2002.04617.x","article-title":"Oral zinc sulphate in the treatment of recalcitrant viral warts: randomized placebo-controlled clinical trial","volume":"146","author":"Al-Gurairi","year":"2002","journal-title":"Br J Dermatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e13308","DOI":"10.1111\/dth.13308","article-title":"Intralesional zinc sulfate 2% vs intralesional vitamin D in plantar warts: a clinicodermoscopic study","volume":"33","author":"El Sayed","year":"2020","journal-title":"Dermatol Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4103\/2229-5178.126034","article-title":"Efficacy of oral zinc therapy in epidermodysplasia verruciformis with squamous cell carcinoma","volume":"5","author":"Sharma","year":"2014","journal-title":"Indian Dermatol Online J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/0253-7184.112867","article-title":"Herpes genitalis - 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