{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:49:59Z","timestamp":1779911399960,"version":"3.53.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Adamantiades-Beh\u00e7et\u2019s disease (ABD) is a chronic-relapsing multisystemic inflammatory disease with unknown etiology first described by a Greek ophthalmology Benediktos Adamantiades and a Turkish dermatology Hulusi Beh\u00e7et. Any organ or apparatus may be involved, though more often there is an involvement of oral and genital mucosae as well as ocular lesions, skin features, and vascular findings. Since there is neither laboratory nor radiological pathognomonic test, the diagnosis is basically clinical according to peculiar signs and symptoms of the disease. With the purpose of giving objectivity and homogeneity to the diagnosis, many authors in time introduced a long series of diagnostic and classification criteria for Adamantiades-Beh\u00e7et\u2019s disease. This mini-review provides an overview of published diagnostic\/classification criteria.<\/jats:p>","DOI":"10.3389\/fmed.2022.1098351","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:59:49Z","timestamp":1670565589000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The diagnosis of Adamantiades-Beh\u00e7et disease: Clinical features and diagnostic\/classification criteria"],"prefix":"10.3389","volume":"9","author":[{"given":"Serena","family":"Bergamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"B1","first-page":"p. 586","author":"Adamantiades","year":"1930","journal-title":"A Case of Relapsing Iritis with Hypopyon (in Greek)."},{"key":"B2","first-page":"143","article-title":"La trombophl\u00e9bite comme quatri\u00e9me symptome de l\u2019iritis r\u00e9cidivant \u00e0 l\u2019hypopyon.","volume":"179","author":"Adamantiades","year":"1946","journal-title":"Ann Ocul."},{"key":"B3","first-page":"846","article-title":"Le symptome complexe de l\u2019uv\u00e9ite r\u00e9cidivante \u00e0 hypopyon.","volume":"186","author":"Adamantiades","year":"1953","journal-title":"Ann Ocul."},{"key":"B4","first-page":"199","article-title":"Severe complications of the central nervous system in the syndrome of relapsing iritis with hypopyon (in Greek).","volume":"26","author":"Adamantiades","year":"1958","journal-title":"Deltion Ellikinis Ophtalmol Etairias."},{"key":"B5","first-page":"1152","article-title":"Uber rezidivierende, aphthose, durch ein virus verursachte geschwure im mund, am auge und an den genitalien.","volume":"105","author":"Beh\u00e7et","year":"1937","journal-title":"Dermatol Wochenschr."},{"key":"B6","first-page":"1037","article-title":"Kurze mitteilung uber fokalsepsis mit aphthosen erscheinungen an mund, genitalien und veranderungen an den augen, als wahrscheinliche folge einer durch virus bedingten allgemeininfektion.","volume":"107","author":"Beh\u00e7et","year":"1938","journal-title":"Dermatol Wochenschr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000253787","article-title":"Some observations on the clinical pictures of the so-called triple symptom complex.","volume":"81","author":"Beh\u00e7et","year":"1940","journal-title":"Dermatologica."},{"key":"B8","first-page":"471","article-title":"Benedictos Adamantiades and his forgotten contribution to medicine.","volume":"12","author":"Zouboulis","year":"2002","journal-title":"Eur J Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"502","DOI":"10.23736\/S2724-5683.21.05847-6","article-title":"Adamantiades-Beh\u00e7et disease: from clinical heterogeneity to diagnosis during the COVID-19 pandemic.","volume":"70","author":"Trevisan","year":"2022","journal-title":"Minerva Cardiol Angiol."},{"key":"B10","first-page":"E6","article-title":"Adamantiades-Behcet disease: an enigmatic process with oral manifestations.","volume":"11","author":"Eguia","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal."},{"key":"B11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10067-009-1106-2","article-title":"Nailfold capillaroscopy in Behcet\u2019s disease, analysis of 128 patients.","volume":"28","author":"Movasat","year":"2009","journal-title":"Clin Rheumatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1001\/archderm.1946.01510370063005","article-title":"Recurrent genito-oral aphthosis with hypopion (Behcet\u2019s syndrome).","volume":"54","author":"Curth","year":"1946","journal-title":"Arch Dermatol."},{"key":"B13","first-page":"565","article-title":"Criteres de prevision du syndrome de Behcet.","volume":"76","author":"Hewitt","year":"1969","journal-title":"Bull Soc Fr Dermatol Syphiligr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1136\/ard.28.2.95","article-title":"Beh\u00e7et\u2019s syndrome with arthritis.","volume":"28","author":"Mason","year":"1969","journal-title":"Ann Rheum Dis."},{"key":"B15","article-title":"Revision of the diagnostic criteria of Behcet\u2019s syndrome.","volume":"79","author":"Hewitt","year":"1971","journal-title":"Press Med."},{"key":"B16","first-page":"291","article-title":"Behcet\u2019s disease guide to the diagnosis of Behcet\u2019s disease (1972).","volume":"18","year":"1974","journal-title":"Japanese J Ophthalmol."},{"key":"B17","first-page":"43","article-title":"La maladie de Beh\u00e7et en 1974","author":"Hubault","year":"1974","journal-title":"L\u2019actualit \u00ece Rhumatologique 15"},{"key":"B18","first-page":"2371","article-title":"Criteres propose \u00ecs pour le diagnostique de la maladie de Behcet et notes therapeutiques.","volume":"36","author":"O\u2019Duffy","year":"1974","journal-title":"Rev Med."},{"key":"B19","first-page":"15","article-title":"\u201cSome special clinical manifestations of Behcet\u2019s disease\u2014report of illustrative cases and review of literature.","volume":"19","author":"Chen","year":"1980","journal-title":"Chinese J Int Med."},{"key":"B20","first-page":"p. 177","article-title":"Our diagnostic criteria of Behcet\u2019s disease\u2014an overview.","author":"Dilsen","year":"1986","journal-title":"Recent Advances in Behcet\u2019s Disease. Vol. 103 of International Congress and Symposium Series."},{"key":"B21","first-page":"59","article-title":"Recent research into Behcet\u2019s disease in Japan.","volume":"10","author":"Mizushima","year":"1988","journal-title":"Int J Tissue React."},{"key":"B22","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et\u2019s disease.","volume":"335","year":"1990","journal-title":"Lancet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/rheumatology\/31.5.299","article-title":"Evaluation of diagnostic (classification) criteria in Beh\u00e7et\u2019s disease-towards internationally agreed criteria.","volume":"31","year":"1992","journal-title":"Br J Rheumatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3349\/ymj.1997.38.6.365","article-title":"Diagnostic criteria of Beh\u00e7et\u2019s disease; problems and suggestions.","volume":"38","author":"Lee","year":"1997","journal-title":"Yonsei Med J."},{"key":"B25","first-page":"p. 245","article-title":"Classification tree for the diagnosis of Behcet\u2019s disease.","author":"Davatchi","year":"1993","journal-title":"Behcet\u2019s Disease."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1479-8077.2005.00121.x","article-title":"New simple way to use the classification tree for the diagnosis of Behcet\u2019s disease.","volume":"8","author":"Davatchi","year":"2005","journal-title":"APLAR J Rheumatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3346\/jkms.2003.18.1.88","article-title":"Survey and validation of the criteria for Beh\u00e7et\u2019s disease recently used in Korea: a suggestion for modification of the international study group criteria.","volume":"18","author":"Chang","year":"2003","journal-title":"J Korean Med Sci."},{"key":"B28","first-page":"S21","article-title":"Validation of the classification criteria commonly used in Korea and a modified set of preliminary criteria for Beh\u00e7et\u2019s disease: a multi-center study.","volume":"22","author":"Chang","year":"2004","journal-title":"Clin Exp Rheumatol."},{"key":"B29","article-title":"Evaluation of the International Criteria for Behcet\u2019s disease (ICBD).","volume":"24","year":"2006","journal-title":"Clin Exp Rheumatol."},{"key":"B30","first-page":"S14","article-title":"Revision of the International Criteria for Behcet\u2019s Disease (ICBD).","volume":"24","year":"2006","journal-title":"Clin Exp Rheumatol."},{"key":"B31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1756-185X.2009.01455.x","article-title":"Validation of the international criteria for Beh\u00e7et\u2019s disease (ICBD) in Iran.","volume":"13","author":"Davatchi","year":"2010","journal-title":"Int J Rheumat Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/0019-5154.113936","article-title":"Analysis of diagnostic criteria in Adamantiades-Beh\u00e7et disease: a retrospective study.","volume":"58","author":"Di Meo","year":"2013","journal-title":"Indian J Dermatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The international criteria for Beh\u00e7et\u2019s disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria.","volume":"28","year":"2014","journal-title":"J Eur Acad Dermatol Venereol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1098351\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:59:59Z","timestamp":1670565599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.1098351\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":33,"alternative-id":["10.3389\/fmed.2022.1098351"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.1098351","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,9]]},"article-number":"1098351"}}