{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:39:22Z","timestamp":1775705962905,"version":"3.50.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Langerhans cell histiocytosis (LCH) is a clonal neoplasm of myeloid dendritic cells, rarely involving the thyroid gland. Papillary thyroid carcinoma (PTC) is the most common histological subtype of thyroid cancer. We report a rare case of a 34-year-old Chinese woman who has LCH with PTC and cervical lymph node metastasis of LCH, with a review of the literature. The patient has thyroid nodules and cervical lymph node enlargement detected by neck ultrasound during physical examination. Fine needle aspiration cytology (FNAC) showed PTC with Hashimoto\u2019s thyroiditis and <jats:italic>BRAF V600E<\/jats:italic> mutation after thyroidectomy and lymph node dissection. Histopathological examination suggests that LCH was concurrent with classical PTC, accompanied by LCH cervical lymph node metastasis. No <jats:italic>BRAF, HRAS<\/jats:italic>, and <jats:italic>TERT<\/jats:italic> promoter mutations were detected in LCH metastatic lesions. The patient is in stable clinical condition currently.<\/jats:p>","DOI":"10.3389\/fmed.2022.1105152","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T05:00:50Z","timestamp":1674104450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Thyroid Langerhans cell histiocytosis concurrent with papillary thyroid carcinoma: A case report and literature review"],"prefix":"10.3389","volume":"9","author":[{"given":"Bin","family":"Mi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Ka Seng","family":"Thong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","first-page":"421","author":"Swerdlow","year":"2017","journal-title":"WHO classification of tumours of haematopoietic and lymphoid tissues."},{"key":"B2","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1056\/NEJMra1607548","article-title":"Langerhans-cell histiocytosis.","volume":"379","author":"Allen","year":"2018","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1517\/14656566.2012.688028","article-title":"Medical management of langerhans cell histiocytosis from diagnosis to treatment.","volume":"13","author":"Donadieu","year":"2012","journal-title":"Exp Opin Pharmacother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/hon.2857","article-title":"Langerhans cell histiocytosis: version 2021.","volume":"39","author":"Gulati","year":"2021","journal-title":"Hematol Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s42000-020-00181-2","article-title":"Langerhans cell histiocytosis of the thyroid together with papillary thyroid carcinoma.","volume":"19","author":"Ozisik","year":"2020","journal-title":"Hormones."},{"key":"B6","first-page":"422","article-title":"Thyromegaly secondary to simultaneous papillary carcinoma and histiocytosis X. 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