{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:48:22Z","timestamp":1790272102708,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the incidence and characteristics of retinopathy of prematurity (ROP) premature infants with late gestational age (GA) and large birth weight (BW) and show a 7-year trend of ROP incidence in South China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, cross-sectional study included premature infants who received ROP screening in a 7-year period (from 2010 to 2016) at the Sun Yat-sen Memorial Hospital (SYSMH), Guangzhou, South China. Infants were screened if they had GA &amp;lt;37 weeks or BW &amp;lt;2,500 g. All screened infants were divided into two groups: Group 1 (with both GA \u2265 35 weeks and BW \u2265 1,750 g) and Group 2 (others). The characteristics of ROP infants in Group 1 were analyzed and compared with those in Group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 911 premature infants were screened, with 282 infants in Group 1 and 629 in Group 2. Both the incidences of any ROP (6.7 vs. 8.3%, <jats:italic>p<\/jats:italic> = 0.50) and Type 1 ROP (1.4 vs. 1.7%, <jats:italic>p<\/jats:italic> = 0.72) in Group 1 were comparable with those in Group 2. Lower proportions of respiratory distress (15.8 vs. 71.2%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), blood transfusion (5.3 vs. 32.7%, <jats:italic>p<\/jats:italic> = 0.028), and oxygen administration (31.6 vs. 86.5%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) among ROP patients in Group 1 than those in Group 2 were revealed. Vaginal delivery [OR: 4.73 (1.83\u201312.26)] was identified as a factor associated with ROP among the infants in Group 1. Forty percent (6\/15) of Type 1 ROP in this study would have been missed under the current screening criteria in China (GA \u2264 34 weeks and\/or BW \u2264 2,000 g). Trends of increased incidence of Type 1 ROP and decreased BW were exhibited in the 7-year study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicate that even the premature infants with late GA and large BW also have a high risk of developing ROP, especially for those delivered by vagina. The findings may provide a significant reference for ROP screening and neonatal care in South China and other regions with similar conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.712759","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T06:47:08Z","timestamp":1646290028000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence and Characteristics of Retinopathy of Prematurity Patients With Late Gestational Age and Large Birth Weight in South China"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunru","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1053\/j.semperi.2015.12.006","article-title":"Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity","volume":"40","author":"Beharry","year":"2016","journal-title":"Semin Perinatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/S0140-6736(16)31405-2","article-title":"The effects of China's universal two-child policy","volume":"388","author":"Zeng","year":"2016","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12886-018-0708-3","article-title":"systematic study on the prevention and treatment of retinopathy of prematurity in China","volume":"18","author":"Xu","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000464459","article-title":"Screening tool for early postnatal prediction of retinopathy of prematurity in preterm newborns (STEP-ROP)","volume":"112","author":"Ricard","year":"2017","journal-title":"Neonatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3928\/23258160-20141118-10","article-title":"Screening for retinopathy of prematurity in a tertiary ophthalmology department in Turkey: incidence, outcomes, and risk factors","volume":"45","author":"Cerman","year":"2014","journal-title":"Ophthalmic Surg Lasers Imag Retin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/5918736","article-title":"Prospective study of the incidence of retinopathy of prematurity in China: evaluation of different screening criteria","volume":"2016","author":"Li","year":"2016","journal-title":"J Ophthalmol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"F280","DOI":"10.1136\/archdischild-2015-310129","article-title":"Screening for retinopathy of prematurity: does one size fit all?","volume":"101","author":"Gilbert","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1542\/peds.2012-2996","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"131","author":"Fierson","year":"2013","journal-title":"Pediatrics."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1038\/eye.2008.128","article-title":"Guideline Development Group of the Royal College of Paediatrics and Child Health, Royal College of Ophthalmologists, British Association of Perinatal Medicine. 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