{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:59:32Z","timestamp":1765382372091,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>An 82-year-old male patient was hospitalized in the Respiratory Department for \u201crepeated cough and shortness of breath for 10 years, recurrence worsened for 1 month.\u201d Later, he was transferred for further diagnosis and treatment, to the Infectious Disease Department for further hospitalization. Previously, the patient had repeatedly undergone tuberculosis-related examinations including bronchoscopy examinations. However, no evidence of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>MTB<\/jats:italic>) infection was found. Early anti-infection treatments failed. Due to repeated symptoms, we performed bronchoscopy again and sent alveolar lavage fluid for the metagenomic next-generation sequencing (mNGS) test. Subsequently, <jats:italic>MTB<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic> were detected by mNGS. After antituberculosis and antifungal treatments, the symptoms were significantly relieved, and the chest CT showed resolution of the lung lesions. Therefore, we successfully diagnosed and treated a case of recurrent pneumonia with tuberculosis and <jats:italic>Candida<\/jats:italic> co-infection diagnosed by mNGS.<\/jats:p>","DOI":"10.3389\/fmed.2022.755308","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:05:06Z","timestamp":1649419506000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Recurrent Pneumonia With Tuberculosis and Candida Co-infection Diagnosed by Metagenomic Next-Generation Sequencing: A Case Report and Literature 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