{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:45:32Z","timestamp":1783464332041,"version":"3.55.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To characterize the clinical features of autoimmune pancreatitis (AIP) in China and compare differences between our Chinese cohort and Western cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of patients with AIP that was carried out in the China-Japan Friendship Hospital between January 2010 and April 2021. We included a total of 50 patients (46 males and 4 females) aged between 27 and 86 years who fulfilled the international Consensus Diagnostic (ICD) Criteria. For comparative purposes, we included data from seven representative Western cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>When comparing Chinese and Western patients, we found that obstructive jaundice was the most frequent initial symptom (68 vs. 43%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). Extra-pancreatic organ involvement was more common in Chinese patients (68 vs. 30%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). Sclerosing cholangitis was the most frequent extrapancreatic lesion (48 vs. 24%, <jats:italic>P<\/jats:italic> = 0.001). The elevation of serum IgG4 was more obvious in our cohort (86 vs. 49%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). Conversely, the rates of ANA-positivity were significantly higher in Western populations (17 vs. 50%, <jats:italic>P<\/jats:italic> = 0.006). With regards to imaging, diffuse swelling was significantly more common in China (44 vs. 27%, <jats:italic>P<\/jats:italic> = 0.021). Steroid therapy was used more frequently in our Chinese patients (84 vs. 59%, <jats:italic>P<\/jats:italic> = 0.001). The steroid-response rate was also significantly higher in our Chinese patients (85 vs. 54%, <jats:italic>P<\/jats:italic> = 0.001); However, the rate of resection was higher in Western cohorts (2 vs. 31%, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). There was no significant difference between the two populations with regards to recurrence rate (33 vs. 33%, <jats:italic>P<\/jats:italic> = 1.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identified significant differences between Chinese and Western populations of patients with AIP. Within the Chinese population, AIP was more likely to have jaundice and extra-pancreatic organ involvement, and elevated serum IgG4 levels. Chinese patients were also showed favorable responses to treatment with glucocorticoids.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.771784","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T05:27:50Z","timestamp":1646630870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Clinical Phenotype of Chinese Patients With Autoimmune Pancreatitis Differs Significantly From Western Patients"],"prefix":"10.3389","volume":"9","author":[{"given":"Qiwen","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpeng","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1007\/bf02285209","article-title":"Chronic pancreatitis caused by an autoimmune abnormality. 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