{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:44:27Z","timestamp":1791434667215,"version":"4.3.3"},"reference-count":159,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Cardiovascular disease and mineral bone disorders are major contributors to morbidity and mortality among patients with chronic kidney disease and often persist after renal transplantation. Ongoing hormonal imbalances after kidney transplant (KT) are associated with loss of graft function and poor outcomes. Fibroblast growth factor 23 (FGF-23) and its co-receptor, \u03b1-Klotho, are key factors in the underlying mechanisms that integrate accelerated atherosclerosis, vascular calcification, mineral disorders, and osteodystrophy. On the other hand, kidney donation is also associated with endocrine and metabolic adaptations that include transient increases in circulating FGF-23 and decreases in \u03b1-Klotho levels. However, the long-term impact of these alterations and their clinical relevance have not yet been determined. This manuscript aims to review and summarize current data on the role of FGF-23 and \u03b1-Klotho in the endocrine response to KT and living kidney donation, and importantly, underscore specific areas of research that may enhance diagnostics and therapeutics in the growing population of KT recipients and kidney donors.<\/jats:p>","DOI":"10.3389\/fmed.2022.803016","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T14:50:04Z","timestamp":1651848604000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Alterations in Alpha-Klotho and FGF-23 in Kidney Transplantation and Kidney Donation"],"prefix":"10.3389","volume":"9","author":[{"given":"Meera","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumati","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gedaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut H.","family":"Malluche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Neyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"B1","volume-title":"2020 Usrds Annual Data Report: Epidemiology of Kidney Disease in the United States","author":"System","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The klotho proteins in health and disease","volume":"15","author":"Kuro","year":"2019","journal-title":"Nat Rev Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5500\/wjt.v5.i4.222","article-title":"Vascular calcification, bone and mineral metabolism after kidney transplantation","volume":"5","author":"D'Marco","year":"2015","journal-title":"World J Transplant."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1093\/ndt\/gfr214","article-title":"Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis\u2013implications for post-transplantation bone disease","volume":"26","author":"Westenfeld","year":"2011","journal-title":"Nephrol Dial Transplant."},{"key":"B5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.bone.2014.01.020","article-title":"Acute and long term mineral metabolism adaptation in living kidney donors: a prospective study","volume":"62","author":"Ponte","year":"2014","journal-title":"Bone."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1097\/TXD.0000000000000660","article-title":"Changes in markers of mineral metabolism after living kidney donation","volume":"3","author":"Tan","year":"2017","journal-title":"Transplant Direct."},{"key":"B7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.transproceed.2012.07.150","article-title":"The impact of nephrectomy and renal transplantation on serum levels of soluble klotho protein","volume":"45","author":"Akimoto","year":"2013","journal-title":"Transplant Proc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/j.transproceed.2015.06.025","article-title":"Impact of renal transplantation and nephrectomy on urinary soluble klotho protein","volume":"47","author":"Kimura","year":"2015","journal-title":"Transplant Proc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"61834","DOI":"10.3390\/jcm9061834","article-title":"Serum klotho in living kidney donors and kidney transplant recipients: a meta-analysis","volume":"9","author":"Thongprayoon","year":"2020","journal-title":"J Clin Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1128\/MCB.02249-06","article-title":"Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members","volume":"27","author":"Goetz","year":"2007","journal-title":"Mol Cell Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1002\/jbmr.4003","article-title":"Il-1beta drives production of fgf-23 at the onset of chronic kidney disease in mice","volume":"35","author":"McKnight","year":"2020","journal-title":"J Bone Miner Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/1873-3468.12040","article-title":"Counter-regulatory paracrine actions of Fgf-23 and 1,25(Oh)2 D in macrophages","volume":"590","author":"Han","year":"2016","journal-title":"FEBS Lett."},{"key":"B13","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor Nf-kappab pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by klotho","volume":"281","author":"Kurosu","year":"2006","journal-title":"J Biol Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical Fgf receptor into a specific receptor for Fgf23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature."},{"key":"B16","doi-asserted-by":"publisher","first-page":"F282","DOI":"10.1152\/ajprenal.90742.2008","article-title":"Fgf23 decreases renal Napi-2a and Napi-2c expression and induces hypophosphatemia in vivo predominantly via Fgf receptor 1","volume":"297","author":"Gattineni","year":"2009","journal-title":"Am J Physiol Renal Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1038\/ki.2011.27","article-title":"Phosphate and Fgf-23","volume":"79121","author":"Juppner","year":"2011","journal-title":"Kidney Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1038\/ki.2011.26","article-title":"Phosphate and Klotho","volume":"79121","author":"Kuro","year":"2011","journal-title":"Kidney Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1172\/JCI81928","article-title":"Cyp24 inhibition as a therapeutic target in Fgf23-mediated renal phosphate wasting disorders","volume":"126","author":"Bai","year":"2016","journal-title":"J Clin Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of Fgf-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"Quarles","year":"2012","journal-title":"Nat Rev Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1172\/JCI32409","article-title":"The parathyroid is a target organ for Fgf23 in rats","volume":"117","author":"Ben-Dov","year":"2007","journal-title":"J Clin Invest."},{"key":"B22","doi-asserted-by":"publisher","first-page":"E310","DOI":"10.1152\/ajpendo.00460.2012","article-title":"Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo","volume":"304","author":"Quinn","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B23","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ndt\/gfm672","article-title":"Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23","volume":"23","author":"Marsell","year":"2008","journal-title":"Nephrol Dial Transplant."},{"key":"B24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse Klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature."},{"key":"B25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1681\/ASN.2014101030","article-title":"Renal production, uptake, and handling of circulating alphaklotho","volume":"27","author":"Hu","year":"2016","journal-title":"J Am Soc Nephrol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1016\/j.febslet.2009.09.009","article-title":"Klotho is a substrate for alpha-, beta- and gamma-secretase","volume":"583","author":"Bloch","year":"2009","journal-title":"FEBS Lett."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19796","DOI":"10.1073\/pnas.0709805104","article-title":"Insulin stimulates the cleavage and release of the extracellular domain of Klotho by Adam10 and Adam17","volume":"104","author":"Chen","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5579","DOI":"10.1021\/bi500409n","article-title":"Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho","volume":"53","author":"Chen","year":"2014","journal-title":"Biochemistry."},{"key":"B29","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1006\/bbrc.1997.8019","article-title":"Identification of the human Klotho gene and its two transcripts encoding membrane and secreted Klotho protein","volume":"242","author":"Matsumura","year":"1998","journal-title":"Biochem Biophys Res Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0014-5793(98)00127-6","article-title":"Structure of the mouse Klotho gene and its two transcripts encoding membrane and secreted protein","volume":"424","author":"Shiraki-Iida","year":"1998","journal-title":"FEBS Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/ki.2013.489","article-title":"Klotho has dual protective effects on cisplatin-induced acute kidney injury","volume":"85","author":"Panesso","year":"2014","journal-title":"Kidney Int."},{"key":"B32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.55782\/ane-2015-2016","article-title":"Signals mediating Klotho-induced neuroprotection in hippocampal neuronal cells","volume":"75","author":"Cheng","year":"2015","journal-title":"Acta Neurobiol Exp."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1177\/1535370215587914","article-title":"Rtef-1 protects against oxidative damage induced by H2o2 in human umbilical vein endothelial cells through Klotho activation","volume":"240","author":"Sun","year":"2015","journal-title":"Exp Biol Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"L566","DOI":"10.1152\/ajplung.00306.2013","article-title":"Alpha-Klotho protects against oxidative damage in pulmonary epithelia","volume":"307","author":"Ravikumar","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e57391","DOI":"10.1371\/journal.pone.0057391","article-title":"Klotho sensitizes human lung cancer cell line to cisplatin via Pi3k\/Akt pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1172\/JCI64986","article-title":"Circulating alphaklotho influences phosphate handling by controlling Fgf23 production","volume":"122","author":"Smith","year":"2012","journal-title":"J Clin Invest."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.kint.2016.10.034","article-title":"Recombinant alpha-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy","volume":"91","author":"Hu","year":"2017","journal-title":"Kidney Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature25451","article-title":"Alpha-Klotho is a non-enzymatic molecular scaffold for Fgf23 hormone signalling","volume":"553","author":"Chen","year":"2018","journal-title":"Nature."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.1096\/fj.10-154765","article-title":"Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ki.2009.24","article-title":"Reversal of mineral ion homeostasis and soft-tissue calcification of Klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase","volume":"75","author":"Ohnishi","year":"2009","journal-title":"Kidney Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/978-1-4614-0887-1_5","article-title":"Fgf23, Klotho and Vitamin D Interactions: what have we learned from in vivo mouse genetics studies?","volume":"728","author":"Razzaque","year":"2012","journal-title":"Adv Exp Med Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/bs.vh.2016.02.007","article-title":"Alphaklotho and chronic kidney disease","volume":"101","author":"Neyra","year":"2016","journal-title":"Vitam Horm."},{"key":"B43","doi-asserted-by":"publisher","first-page":"F1252","DOI":"10.1152\/ajprenal.00294.2011","article-title":"Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis","volume":"302","author":"Sugiura","year":"2012","journal-title":"Am J Physiol Renal Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.1074\/jbc.M110.174037","article-title":"Klotho inhibits transforming growth factor-beta1 (Tgf-Beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice","volume":"286","author":"Doi","year":"2011","journal-title":"J Biol Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.2147\/CIA.S84978","article-title":"Klotho, stem cells, and aging","volume":"10","author":"Bian","year":"2015","journal-title":"Clin Interv Aging."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1681\/ASN.2015060613","article-title":"Alphaklotho mitigates progression of Aki to Ckd through activation of autophagy","volume":"27","author":"Shi","year":"2016","journal-title":"J Am Soc Nephrol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"15269","DOI":"10.1096\/fj.202000596R","article-title":"Relationship between Gfr, Intact Pth, Oxidized Pth, non-oxidized Pth as well as Fgf23 in patients with Ckd","volume":"34","author":"Zeng","year":"2020","journal-title":"FASEB J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ki.2015.231","article-title":"Key role of the kidney in the regulation of fibroblast growth factor 23","volume":"88","author":"Mace","year":"2015","journal-title":"Kidney Int."},{"key":"B50","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.kint.2017.01.015","article-title":"Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia","volume":"92","author":"Mace","year":"2017","journal-title":"Kidney Int."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1111\/j.1523-1755.2004.00604.x","article-title":"Fgf-23 in patients with end-stage renal disease on hemodialysis","volume":"65","author":"Imanishi","year":"2004","journal-title":"Kidney Int."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1681\/ASN.2005010052","article-title":"Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease","volume":"16","author":"Gutierrez","year":"2005","journal-title":"J Am Soc Nephrol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.semnephrol.2014.09.005","article-title":"New insights into the Fgf23-Klotho axis","volume":"34","author":"Olauson","year":"2014","journal-title":"Semin Nephrol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.111.053405","article-title":"Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23","volume":"125","author":"Lim","year":"2012","journal-title":"Circulation."},{"key":"B55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.semnephrol.2018.10.005","article-title":"Fibroblast growth factor 23 and Klotho in Aki","volume":"39","author":"Christov","year":"2019","journal-title":"Semin Nephrol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"162","DOI":"10.2215\/CJN.02840320","article-title":"Klotho in clinical nephrology: diagnostic and therapeutic implications","volume":"16","author":"Neyra","year":"2020","journal-title":"Clin J Am Soc Nephrol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ki.1980.85","article-title":"Renal toxicity of phosphate in rats","volume":"17","author":"Haut","year":"1980","journal-title":"Kidney Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1126\/science.1143578","article-title":"Augmented Wnt signaling in a mammalian model of accelerated aging","volume":"317","author":"Liu","year":"2007","journal-title":"Science."},{"key":"B59","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1681\/ASN.2015080888","article-title":"Klotho may ameliorate proteinuria by targeting Trpc6 channels in podocytes","volume":"28","author":"Kim","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation."},{"key":"B61","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N Engl J Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"J Am Med Assoc."},{"key":"B63","doi-asserted-by":"publisher","first-page":"640","DOI":"10.7326\/0003-4819-152-10-201005180-00004","article-title":"The associations of fibroblast growth factor 23 and uncarboxylated matrix gla protein with mortality in coronary artery disease: the heart and soul study","volume":"152","author":"Parker","year":"2010","journal-title":"Ann Intern Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"Fgf23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","article-title":"Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease","volume":"119","author":"Gutierrez","year":"2009","journal-title":"Circulation."},{"key":"B67","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/TP.0000000000000903","article-title":"The kidney-vascular-bone axis in the chronic kidney disease-mineral bone disorder","volume":"100","author":"Seifert","year":"2016","journal-title":"Transplantation."},{"key":"B68","doi-asserted-by":"publisher","first-page":"644363","DOI":"10.3389\/fcell.2021.644363","article-title":"Hyperphosphatemia and cardiovascular disease","volume":"9","author":"Zhou","year":"2021","journal-title":"Front Cell Dev Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s11255-016-1231-1","article-title":"Fgf-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients","volume":"48","author":"Turan","year":"2016","journal-title":"Int Urol Nephrol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1161\/01.ATV.0000160548.78317.29","article-title":"Mechanisms, pathophysiology, and therapy of arterial stiffness","volume":"25","author":"Zieman","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/bs.acc.2018.12.003","article-title":"Clinical implications of fetuin-A","volume":"89","author":"Jirak","year":"2019","journal-title":"Adv Clin Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1093\/ndt\/gfr609","article-title":"Phosphorylated fetuin-a-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis Ckd","volume":"27","author":"Smith","year":"2012","journal-title":"Nephrol Dial Transplant."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1161\/ATVBAHA.119.312705","article-title":"Atherosclerosis in chronic kidney disease: more, less, or just different?","volume":"39","author":"Valdivielso","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"F1381","DOI":"10.1152\/ajprenal.00003.2008","article-title":"Increased inorganic phosphate induces human endothelial cell apoptosis in vitro","volume":"294","author":"Di Marco","year":"2008","journal-title":"Am J Physiol Renal Physiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1093\/ndt\/15.7.1014","article-title":"Arterial stiffening and vascular calcifications in end-stage renal disease","volume":"15","author":"Guerin","year":"2000","journal-title":"Nephrol Dial Transplant."},{"key":"B76","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int."},{"key":"B77","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1046\/j.1523-1755.1998.00981.x","article-title":"Immunologic function and survival in hemodialysis patients","volume":"54","author":"Kimmel","year":"1998","journal-title":"Kidney Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/ki.1994.117","article-title":"Plasma levels of Il-1 beta, Tnf alpha and their specific inhibitors in undialyzed chronic renal failure, capd and hemodialysis patients","volume":"45","author":"Pereira","year":"1994","journal-title":"Kidney Int."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.2215\/CJN.03500412","article-title":"Association between albuminuria, kidney function, and inflammatory biomarker profile in Ckd in Cric","volume":"7","author":"Gupta","year":"2012","journal-title":"Clin J Am Soc Nephrol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2180373","DOI":"10.1155\/2018\/2180373","article-title":"Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome","volume":"2018","author":"Mihai","year":"2018","journal-title":"J Immunol Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1172\/JCI83470","article-title":"Fgf23 signaling impairs neutrophil recruitment and host defense during Ckd","volume":"126","author":"Rossaint","year":"2016","journal-title":"J Clin Invest."},{"key":"B82","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrneph.2013.198","article-title":"Evaluating bone quality in patients with chronic kidney disease","volume":"9","author":"Malluche","year":"2013","journal-title":"Nat Rev Nephrol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (Kdigo)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1002\/jbmr.4141","article-title":"Incidence of fractures before and after dialysis initiation","volume":"35","author":"Iseri","year":"2020","journal-title":"J Bone Miner Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/archinte.167.2.133","article-title":"Renal function and risk of hip and vertebral fractures in older women","volume":"167","author":"Ensrud","year":"2007","journal-title":"Arch Intern Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.atherosclerosis.2018.08.046","article-title":"Ckd, Arterial calcification, atherosclerosis and bone health: inter-relationships and controversies","volume":"278","author":"Reiss","year":"2018","journal-title":"Atherosclerosis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/jbmr.309","article-title":"Renal osteodystrophy in the first decade of the new millennium: analysis of 630 bone biopsies in black and white patients","volume":"26","author":"Malluche","year":"2011","journal-title":"J Bone Miner Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/ki.1994.342","article-title":"Evidence for abnormal calcium homeostasis in patients with adynamic bone disease","volume":"46","author":"Kurz","year":"1994","journal-title":"Kidney Int."},{"key":"B89","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.matbio.2004.09.007","article-title":"Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice","volume":"23","author":"Sitara","year":"2004","journal-title":"Matrix Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e1000154","DOI":"10.1371\/journal.pgen.1000154","article-title":"Genetic evidence of serum phosphate-independent functions of Fgf-23 on bone","volume":"4","author":"Sitara","year":"2008","journal-title":"PLoS Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1359\/jbmr.080220","article-title":"Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro","volume":"23","author":"Wang","year":"2008","journal-title":"J Bone Miner Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.kint.2017.04.012","article-title":"Is osteocyte Klotho bad for bone health?","volume":"92","author":"Moyses","year":"2017","journal-title":"Kidney Int."},{"key":"B93","doi-asserted-by":"publisher","first-page":"144855","DOI":"10.1016\/j.gene.2020.144855","article-title":"Alkaline phosphatase: structure, expression and its function in bone mineralization","volume":"754","author":"Vimalraj","year":"2020","journal-title":"Gene."},{"key":"B94","doi-asserted-by":"publisher","first-page":"e1002427","DOI":"10.1371\/journal.pbio.1002427","article-title":"Excessive osteocytic Fgf23 secretion contributes to pyrophosphate accumulation and mineralization defect in Hyp mice","volume":"14","author":"Murali","year":"2016","journal-title":"PLoS Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/jbmr.2079","article-title":"Increased osteopontin contributes to inhibition of bone mineralization in Fgf23-deficient mice","volume":"29","author":"Yuan","year":"2014","journal-title":"J Bone Miner Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.bone.2011.06.025","article-title":"Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo","volume":"49","author":"Rhee","year":"2011","journal-title":"Bone"},{"key":"B97","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.kint.2017.02.014","article-title":"Klotho expression in osteocytes regulates bone metabolism and controls bone formation","volume":"92","author":"Komaba","year":"2017","journal-title":"Kidney Int."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.2215\/CJN.03950417","article-title":"Fibroblast growth factor 23 and anemia in the chronic renal insufficiency cohort study","volume":"12","author":"Mehta","year":"2017","journal-title":"Clin J Am Soc Nephrol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"7294","DOI":"10.1038\/s41598-018-25439-z","article-title":"Circulating fibroblast growth factor-23 levels are associated with an increased risk of anemia development in patients with nondialysis chronic kidney disease","volume":"8","author":"Nam","year":"2018","journal-title":"Sci Rep."},{"key":"B100","doi-asserted-by":"publisher","first-page":"9795","DOI":"10.1074\/jbc.M113.527150","article-title":"Fgf-23 is a negative regulator of prenatal and postnatal erythropoiesis","volume":"289","author":"Coe","year":"2014","journal-title":"J Biol Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1096\/fj.201700667R","article-title":"Inhibition of fibroblast growth factor 23 (Fgf23) signaling rescues renal anemia","volume":"32","author":"Agoro","year":"2018","journal-title":"FASEB J."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1038\/ki.2009.189","article-title":"Chapter 1: introduction and definition of Ckd\u2013Mbd and the development of the guideline statements","volume":"76","year":"2009","journal-title":"Kidney Int."},{"key":"B104","first-page":"S100","volume":"76113","year":"2009","journal-title":"Kidney Int."},{"key":"B105","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1530\/EJE-10-1150","article-title":"Early post-transplantation hypophosphatemia is associated with elevated Fgf-23 levels","volume":"164","author":"Trombetti","year":"2011","journal-title":"Eur J Endocrinol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.2215\/CJN.10270916","article-title":"Post-transplant hypophosphatemia and the risk of death-censored graft failure and mortality after kidney transplantation","volume":"12","author":"van Londen","year":"2017","journal-title":"Clin J Am Soc Nephrol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.transproceed.2011.11.046","article-title":"Elevated fibroblast growth factor 23 levels as a cause of early post-renal transplantation hypophosphatemia","volume":"44","author":"Han","year":"2012","journal-title":"Transplant Proc."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1093\/ndt\/gfq777","article-title":"The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor kidney transplantation: a 1-year prospective observational study","volume":"26","author":"Kawarazaki","year":"2011","journal-title":"Nephrol Dial Transplant."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1007\/s00467-013-2547-z","article-title":"Fgf23 and mineral metabolism in the early post-renal transplantation period","volume":"28","author":"Wesseling-Perry","year":"2013","journal-title":"Pediatr Nephrol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1530\/EJE-14-0457","article-title":"Soluble Klotho and intact fibroblast growth factor 23 in long-term kidney transplant patients","volume":"172","author":"Bleskestad","year":"2015","journal-title":"Eur J Endocrinol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000183690","article-title":"High plasma ionized calcium with normal Pth and total calcium levels in normal-function kidney transplant recipients","volume":"42","author":"Vezzoli","year":"1986","journal-title":"Nephron."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1111\/j.1600-6143.2007.01978.x","article-title":"Vitamin D status in renal transplant recipients","volume":"7","author":"Stavroulopoulos","year":"2007","journal-title":"Am J Transplant."},{"key":"B113","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1097\/01.TP.0000116417.03114.87","article-title":"Calcium levels as a risk factor for delayed graft function","volume":"77","author":"Boom","year":"2004","journal-title":"Transplantation."},{"key":"B114","first-page":"S175","article-title":"Calcium and phosphate changes after renal transplantation","volume":"23","author":"Messa","year":"2010","journal-title":"J Nephrol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3265\/Nefrologia.pre2013.Aug.11888","article-title":"Management of hypercalcemia after renal transplantation","volume":"33","author":"Torregrosa","year":"2013","journal-title":"Nefrologia."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e0178637","DOI":"10.1371\/journal.pone.0178637","article-title":"Interactions of sclerostin with Fgf23, soluble Klotho and vitamin D in renal transplantation","volume":"12","author":"Tartaglione","year":"2017","journal-title":"PLoS ONE."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.2215\/CJN.01310308","article-title":"Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation","volume":"3","author":"Evenepoel","year":"2008","journal-title":"Clin J Am Soc Nephrol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.1093\/ndt\/gfs409","article-title":"Serum level of fibroblast growth factor 23 in maintenance renal transplant patients","volume":"27","author":"Sanchez Fructuoso","year":"2012","journal-title":"Nephrol Dial Transplant."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1016\/j.transproceed.2014.09.015","article-title":"Fgf23 and Klotho in relation to markers of endothelial dysfunction in kidney transplant recipients","volume":"46","author":"Malyszko","year":"2014","journal-title":"Transplant Proc."},{"key":"B120","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1681\/ASN.2010080894","article-title":"Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality","volume":"22","author":"Wolf","year":"2011","journal-title":"J Am Soc Nephrol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.2215\/CJN.01880213","article-title":"Fibroblast growth factor 23 and cardiovascular mortality after kidney transplantation","volume":"8","author":"Baia","year":"2013","journal-title":"Clin J Am Soc Nephrol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000346711","article-title":"Longitudinal analysis of vascular function and biomarkers of metabolic bone disorders before and after renal transplantation","volume":"37","author":"Yilmaz","year":"2013","journal-title":"Am J Nephrol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1097\/00007890-199511000-00005","article-title":"Impact of renal transplantation on uremic cardiomyopathy","volume":"60","author":"Parfrey","year":"1995","journal-title":"Transplantation."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1111\/j.1600-6143.2008.02407.x","article-title":"Severe left ventricular systolic dysfunction may reverse with renal transplantation: uremic cardiomyopathy and cardiorenal syndrome","volume":"8","author":"Zolty","year":"2008","journal-title":"Am J Transplant."},{"key":"B125","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11255-021-02982-9","article-title":"The relationship between Fgf23 and anemia in Hd and renal transplant patients","volume":"21","author":"Baloglu","year":"2021","journal-title":"Int Urol Nephrol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/tri.12925","article-title":"Mineral adaptations following kidney transplantation","volume":"30","author":"Tan","year":"2017","journal-title":"Transpl Int."},{"key":"B127","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000496630","article-title":"Inhibition of the mammalian target of rapamycin may augment the increase in soluble Klotho levels in renal transplantation recipients","volume":"47","author":"Mizusaki","year":"2019","journal-title":"Blood Purif."},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000543389.60945.78","article-title":"The potential role of klotho as a prognostic biomarker in deceased donor kidney transplantation","author":"Kim","year":"2018","journal-title":"Transplantation."},{"key":"B129","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/ndt\/gfp451","article-title":"Klotho reduces apoptosis in experimental ischaemic acute kidney injury via Hsp-70","volume":"25","author":"Sugiura","year":"2010","journal-title":"Nephrol Dial Transplant."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/ndt\/gfi165","article-title":"Klotho reduces apoptosis in experimental ischaemic acute renal failure","volume":"20","author":"Sugiura","year":"2005","journal-title":"Nephrol Dial Transplant."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/ki.2010.328","article-title":"Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective","volume":"78","author":"Hu","year":"2010","journal-title":"Kidney Int."},{"key":"B132","doi-asserted-by":"publisher","first-page":"7936","DOI":"10.12659\/MSM.913274","article-title":"The value of older donors' Klotho level in predicting recipients' short-term renal function","volume":"24","author":"Deng","year":"2018","journal-title":"Med Sci Monit."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1046\/j.1523-1755.2003.00938.x","article-title":"The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling","volume":"63","author":"Rojas","year":"2003","journal-title":"Kidney Int."},{"key":"B134","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.1046\/j.1523-1755.63.s85.30.x","article-title":"Bone remodeling after renal transplantation","volume":"85","author":"Bellorin-Font","year":"2003","journal-title":"Kidney Int Suppl."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1097\/TP.0b013e3181a6bbda","article-title":"Risk of fractures after renal transplantation in the United States","volume":"87","author":"Nikkel","year":"2009","journal-title":"Transplantation."},{"key":"B136","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00007890-200301150-00009","article-title":"Bone mineral density changes within six months of renal transplantation","volume":"75","author":"Mikuls","year":"2003","journal-title":"Transplantation."},{"key":"B137","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1056\/NEJM199108223250804","article-title":"Rapid loss of vertebral mineral density after renal transplantation","volume":"325","author":"Julian","year":"1991","journal-title":"N Engl J Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1097\/01.TP.0000131990.13277.28","article-title":"Early rapid loss followed by long-term consolidation characterizes the development of lumbar bone mineral density after kidney transplantation","volume":"77","author":"Brandenburg","year":"2004","journal-title":"Transplantation."},{"key":"B139","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1172\/JCI2799","article-title":"Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone","volume":"102","author":"Weinstein","year":"1998","journal-title":"J Clin Invest."},{"key":"B140","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1749-6632.2002.tb04204.x","article-title":"Mechanisms of glucocorticoid action in bone","volume":"966","author":"Canalis","year":"2002","journal-title":"Ann N Y Acad Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrneph.2009.192","article-title":"Bone disease after renal transplantation","volume":"6","author":"Malluche","year":"2010","journal-title":"Nat Rev Nephrol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1046\/j.1523-1755.2000.00341.x","article-title":"Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation","volume":"58","author":"Westeel","year":"2000","journal-title":"Kidney Int."},{"key":"B143","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1097\/01.tp.0000203557.36884.e3","article-title":"Lumbar bone mineral density in renal transplant patients on neoral and tacrolimus: a four-year prospective study","volume":"81","author":"Marcen","year":"2006","journal-title":"Transplantation."},{"key":"B144","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/00007890-200103150-00011","article-title":"Osteoporosis after renal transplantation: single center experience","volume":"71","author":"Ugur","year":"2001","journal-title":"Transplantation."},{"key":"B145","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s00198-003-1532-y","article-title":"Long-term fracture risk following renal transplantation: a population-based study","volume":"15","author":"Vautour","year":"2004","journal-title":"Osteoporos Int."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1359\/jbmr.2001.16.10.1863","article-title":"Prevalence and causes of low bone density and fractures in kidney transplant patients","volume":"16","author":"Patel","year":"2001","journal-title":"J Bone Miner Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1097\/00007890-199505270-00006","article-title":"Prevention of cancellous bone loss but persistence of renal bone disease despite normal 1,25 vitamin D levels two years after kidney transplantation","volume":"59","author":"Briner","year":"1995","journal-title":"Transplantation."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.2215\/CJN.11371015","article-title":"Bone disease after kidney transplantation","volume":"11","author":"Bouquegneau","year":"2016","journal-title":"Clin J Am Soc Nephrol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.2215\/CJN.00950110","article-title":"Fibroblast growth factor-23 and parathyroid hormone are associated with post-transplant bone mineral density loss","volume":"5","author":"Kanaan","year":"2010","journal-title":"Clin J Am Soc Nephrol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1053\/j.ackd.2011.09.005","article-title":"Risks and outcomes of living donation","volume":"19","author":"Lentine","year":"2012","journal-title":"Adv Chronic Kidney Dis."},{"key":"B151","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jama.2010.237","article-title":"Perioperative mortality and long-term survival following live kidney donation","volume":"303","author":"Segev","year":"2010","journal-title":"J Am Med Assoc."},{"key":"B152","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1056\/NEJMoa0804883","article-title":"Long-term consequences of kidney donation","volume":"360","author":"Ibrahim","year":"2009","journal-title":"N Engl J Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"276","DOI":"10.7326\/M17-1235","article-title":"Mid- and long-term health risks in living kidney donors: a systematic review and meta-analysis","volume":"168","author":"O'Keeffe","year":"2018","journal-title":"Ann Intern Med."},{"key":"B154","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation","volume":"311","author":"Muzaale","year":"2014","journal-title":"J Am Med Assoc."},{"key":"B155","volume-title":"Provisional Life Expectancy Estimates for January through June, 2020. Vital Statistics Rapid Release no 10","author":"Arias","year":"2020"},{"key":"B156","doi-asserted-by":"publisher","first-page":"e0235082","DOI":"10.1371\/journal.pone.0235082","article-title":"Effect of kidney donation on bone mineral metabolism","volume":"15","author":"Hiemstra","year":"2020","journal-title":"PLoS ONE."},{"key":"B157","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000450621","article-title":"Neutrophil gelatinase-associated lipocalin, fibroblast growth factor 23, and soluble klotho in long-term kidney donors","volume":"6","author":"Thorsen","year":"2016","journal-title":"Nephron Extra."},{"key":"B158","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1053\/j.ajkd.2011.09.019","article-title":"Bone and mineral metabolism and fibroblast growth factor 23 levels after kidney donation","volume":"59","author":"Young","year":"2012","journal-title":"Am J Kidney Dis."},{"key":"B159","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.1093\/ndt\/gfq288","article-title":"Fibroblast growth factor-23 and mineral metabolism after unilateral nephrectomy","volume":"25","author":"Westerberg","year":"2010","journal-title":"Nephrol Dial Transplant."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.803016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T04:27:04Z","timestamp":1700540824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.803016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":159,"alternative-id":["10.3389\/fmed.2022.803016"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.803016","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]},"article-number":"803016"}}