{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:53:51Z","timestamp":1794099231267,"version":"4.8.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012632","name":"Nazarbayev University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Abdominal surgery is one of the most definitive and mainstay treatment options for abdominal pathologies in clinical practice. Acute postoperative pain is a major challenge in the postoperative period. Although opioids are commonly used for analgesia after major abdominal surgeries, they can lead to side effects, such as nausea and vomiting, constipation, pruritus, and life-threatening respiratory depression. Regional anesthetic techniques are commonly used to prevent or minimize these side effects. The objective of this meta-analysis is to assess the effectiveness of erector spinae plane block (ESPB) and standard medical (no block) pain management after major abdominal surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched for articles reporting the results of randomized controlled trials on ESPB and no block in pain control published before May 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The systematic search initially yielded 56 publications, 49 articles were excluded, and seven randomized clinical trials were included and analyzed. We extracted the data on postoperative opioid consumption, the efficacy of pain relief, time to the first opioid demand, and the rate of postoperative complications in the ESPB group and no block group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Opioid requirement and time to first analgesic request were significantly reduced in the ultrasound-guided ESPB group, but pain scores, nausea, and vomiting did not differ significantly after pooling the results of the block and no block studies. There were no reports on serious complications related to ESPB.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.812531","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:36:15Z","timestamp":1645605375000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Erector Spinae Plane Block in Abdominal Surgery: A Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Dmitriy","family":"Viderman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Aubakirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerkin G.","family":"Abdildin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1213\/ANE.0b013e3181d8a095","article-title":"Intraoperative methadone improves postoperative pain control in patients undergoing complex spine surgery","volume":"112","author":"Gottschalk","year":"2011","journal-title":"Anesth Analg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/EJA.0000000000000366","article-title":"Current issues in postoperative pain management","volume":"33","author":"Rawal","year":"2016","journal-title":"Eur J Anaesthesiol"},{"key":"B3","article-title":"In: Principles and Practice of Pharmacology for Anaesthetists","author":"Front","year":"2009"},{"key":"B4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s00595-017-1616-5","article-title":"A new postoperative pain management (intravenous acetaminophen: Acelio\u00ae) leads to enhanced recovery after esophagectomy: a propensity score-matched analysis","volume":"48","author":"Ohkura","year":"2018","journal-title":"Surg Today"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.21037\/jtd.2018.02.48","article-title":"The role of local anaesthetic techniques in ERAS protocols for thoracic surgery","volume":"10","author":"Crumley","year":"2018","journal-title":"J Thorac Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1053\/j.jvca.2018.03.001","article-title":"The year in thoracic anesthesia: selected highlights from 2017","volume":"32","author":"Boisen","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/AAP.0000000000000451","article-title":"The erector spinae plane block: a novel analgesic technique in thoracic neuropathic pain","volume":"41","author":"Forero","year":"2016","journal-title":"Reg Anesth Pain Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1515\/sjpain-2020-0171","article-title":"Erector spinae plane block in acute interventional pain management: a systematic review","volume":"21","author":"Viderman","year":"2021","journal-title":"Scand J Pain"},{"key":"B9","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1177\/0300891620985935","article-title":"Erector spinae plane block in chronic pain management: a scoping review","volume":"107","author":"Viderman","year":"2021","journal-title":"Tumori"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jpainsymman.2009.06.001","article-title":"Opioid rotation: the science and the limitations of the equianalgesic dose table","volume":"38","author":"Knotkova","year":"2009","journal-title":"J Pain Symptom Manage"},{"key":"B13","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1177\/0269216311406577","article-title":"Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review","volume":"25","author":"Mercadante","year":"2011","journal-title":"Palliat Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/LRA.S143618","article-title":"Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies","volume":"11","author":"Santonocito","year":"2018","journal-title":"Local Reg Anesth"},{"key":"B15","doi-asserted-by":"publisher","first-page":"816","DOI":"10.23736\/S0375-9393.20.14064-1","article-title":"Comparison between the ultrasound-guided erector spinae block and the subcostal approach to the transversus abdominis plane block in obese patients undergoing sleeve gastrectomy: a randomized controlled trial","volume":"86","author":"Abdelhamid","year":"2020","journal-title":"Minerva Anestesiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1213\/ANE.0000000000004071","article-title":"Ultrasound-guided erector spinae plane block in patients undergoing open epigastric hernia repair: a prospective randomized controlled study","volume":"129","author":"Abu Elyazed","year":"2019","journal-title":"Anesth Analg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.2147\/JPR.S196501","article-title":"Erector spinae plane block for postoperative analgesia in patients undergoing total abdominal hysterectomy: a randomized controlled study original study","volume":"12","author":"Hamed","year":"2019","journal-title":"J Pain Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.36076\/ppj.2020\/23\/375","article-title":"Bilateral ultrasound-guided erector spinae plane block versus transversus abdominis plane block on postoperative analgesia after total abdominal hysterectomy","volume":"23","author":"Kamel","year":"2020","journal-title":"Pain Physician"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S106","DOI":"10.1097\/EJA.0000000000001475","article-title":"Ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic liver resection: a prospective, randomised controlled, patient and observer-blinded study","volume":"38","author":"Kim","year":"2021","journal-title":"Eur J Anaesthesiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"480","DOI":"10.4103\/sja.SJA_26_20","article-title":"Postoperative analgesic efficacy of fluoroscopy-guided erector spinae plane block after percutaneous nephrolithotomy (PCNL): a randomized controlled study","volume":"14","author":"Prasad","year":"2020","journal-title":"Saudi J Anaesth"},{"key":"B21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jclinane.2018.06.019","article-title":"Evaluation of ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic cholecystectomy: a prospective, randomized, controlled clinical trial","volume":"49","author":"Tulgar","year":"2018","journal-title":"J Clin Anesth"},{"key":"B22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12871-021-01277-x","article-title":"Analgesic efficacy and safety of erector spinae plane block in breast cancer surgery: a systematic review and meta-analysis","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/SPC.0000000000000208","article-title":"Opioids and cancer: friend or foe?","volume":"10","author":"Wigmore","year":"2016","journal-title":"Curr Opin Support Palliat Care"},{"key":"B24","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/AJP.0b013e3181dee988","article-title":"Severity of acute pain after breast surgery is associated with the likelihood of subsequently developing persistent pain","volume":"26","author":"Hickey","year":"2010","journal-title":"Clin J Pain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jclinane.2019.03.012","article-title":"Ultrasound-guided erector spinae plane block versus oblique subcostal transversus abdominis plane block for postoperative analgesia of adult patients undergoing laparoscopic cholecystectomy: randomized, controlled trial","volume":"57","author":"Altiparmak","year":"2019","journal-title":"J Clin Anesth"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/pm\/pny221","article-title":"Erector spinae plane block in management of pain after kidney transplantation","volume":"20","author":"Temirov","year":"2019","journal-title":"Pain Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1097\/ACO.0b013e32830815d1","article-title":"Ultrasound-guided peripheral nerve blockade","volume":"21","author":"Chin","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.redare.2020.10.005","article-title":"Analysis of bupivacaine and ropivacaine-related cardiac arrests in regional anesthesia: a systematic review of case reports","volume":"68","author":"Viderman","year":"2021","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"B29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12871-019-0700-3","article-title":"Comparison of the efficacy of erector spinae plane block performed with different concentrations of bupivacaine on postoperative analgesia after mastectomy surgery: ramdomized, prospective, double blinded trial","volume":"19","author":"Altiparmak","year":"2019","journal-title":"BMC Anesthesiol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.812531\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:36:18Z","timestamp":1645605378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.812531\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":29,"alternative-id":["10.3389\/fmed.2022.812531"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.812531","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]},"article-number":"812531"}}