{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:45:45Z","timestamp":1791693945203,"version":"4.3.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Some research has suggested that dental plaque and saliva could be reservoirs of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) and be capable of infecting or re-infecting the gastric mucosa after eradication, with certain studies showing a significant association between PD and gastric infection by this bacterium. An electronic search was performed in PubMed, EMBASE, and Web of Science databases with the terms \u201c<jats:italic>Helicobacter pylori<\/jats:italic> AND periodontal diseases\u201d; \u201c<jats:italic>Helicobacter pylori<\/jats:italic> AND gingivitis\u201d; \u201c<jats:italic>Helicobacter pylori<\/jats:italic> AND chronic periodontitis\u201d; \u201c<jats:italic>Helicobacter pylori<\/jats:italic> AND periodontitis\u201d; \u201c<jats:italic>Helicobacter pylori<\/jats:italic> AND dental plaque\u201d, to identify articles up to September 2021. The Newcastle-Ottawa scale was used to assess study quality. A meta-analysis was performed using RevMan 2020 (Cochane Collaboration) software. A total of 1,315 studies were identified and 12 were included, analyzing 226,086 patients with mean age between 10.5 and 63.4 years. The prevalence of <jats:italic>H. pylori<\/jats:italic> in the oral cavity ranged from 5.4 to 83.3%. A random-effects model was used to analyze the presence of <jats:italic>H. pylori<\/jats:italic> and subgroups were made according to the method of evaluation (PCR or RUT). Statistical significance was found in the overall analysis (<jats:italic>p<\/jats:italic> = 0.01). There is no clear evidence that <jats:italic>H. pylori<\/jats:italic> present in oral bacterial plaque causes gastric infection and vice versa.<\/jats:p><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p><jats:ext-link>www.INPLASY.COM<\/jats:ext-link>, identifier: INPLASY2021100097.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.822194","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T13:25:01Z","timestamp":1650374701000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Possible Association of Periodontal Diseases With Helicobacter pylori Gastric Infection: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Nansi","family":"L\u00f3pez-Valverde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Macedo de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"L\u00f3pez-Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Aragoneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.3390\/jcm10163473","article-title":"Clinical Relevance of Helicobacter pylori Infection","volume":"10","author":"Mladenova","year":"2021","journal-title":"J Clin Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/life11070650","article-title":"A retrospective experience of Helicobacter pylori histology in a large sample of subjects in Northern Italy","volume":"11","author":"Ribaldone","year":"2021","journal-title":"Life."},{"key":"B3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/23744235.2019.1588472","article-title":"Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. 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