{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:43:44Z","timestamp":1770741824511,"version":"3.49.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Renal medullary carcinoma (RMC) is a rare entity with poor prognosis bearing inactivating genomic alterations in <jats:italic>SMARCB1\/INI1<\/jats:italic> resulting in the loss of expression of INI1 and occurring in young patients with sickle cell trait or sickle cell disease. Recently, rare examples with histological characteristics of RMC have been described in older patients without hemoglobinopathies and provisionally termed \u201cRenal cell carcinoma unclassified with medullary phenotype\u201d (RCCU-MP). Fluorescence <jats:italic>in situ<\/jats:italic> Hybridization (FISH) can detect alterations in <jats:italic>SMARCB1\/INI1<\/jats:italic> consisting mostly in inactivating translocation of one allele and deletion of the second. To date, only seven further cases of RCCU-MP have been described in the literature. Here we report the second Italian case of RCCU-MP, a 62-year-old man presenting with persistent dull back pain and incidentally discovering a 13 cm mass in the right kidney. The nomenclature of this entity is still debated and might be updated as a variant of medullary carcinoma in the upcoming WHO classification. In the meantime, we encourage awareness of these extraordinarily rare neoplasms with poor outcomes.<\/jats:p>","DOI":"10.3389\/fmed.2022.835599","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T04:43:17Z","timestamp":1644208997000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Unclassified Renal Cell Carcinoma With Medullary Phenotype and SMARCB1\/INI1 Deficiency, Broadening the Spectrum of Medullary Carcinoma"],"prefix":"10.3389","volume":"9","author":[{"given":"Marina","family":"Valeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Cieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia 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