{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:34:13Z","timestamp":1770748453109,"version":"3.50.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hemangioblastoma-like clear cell stromal tumor (HLCCST) is a recently reported neoplasm of the lung. Only 13 cases have been reported in four recent studies. Because HLCCST is very rare, it has not been included in the 2021 WHO classification of lung tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report a case of HLCCST of the left lower lung in a 40-year-old female who was admitted to our hospital after pulmonary nodules were discovered. A plain chest CT scan showed a nodular high-density shadow measuring approximately 8 mm in diameter in the left lower lung. The lesion had clear borders, uneven internal density, and a low-density central vacuolar area. The left lower lung was partially resected by video-assisted thoracic surgery. Post-operative histopathologic diagnosis \u201chemangioblastoma-like clear cell stromal tumor\u201d of the left lower lung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HLCCST is an extremely rare tumor and needs long-term follow-up after operation. Clinically, it may be easily confused with other benign and malignant tumors of the lung, and diagnosis is solely determined by histopathologic examination. This case suggests that immunohistochemical CD34 can be a strong positive marker.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.836012","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:01:40Z","timestamp":1650258100000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Hemangioblastoma- Like Clear Cell Stromal Tumor of the Left Lower Lung"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiaowei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bifei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongquan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1007\/s00381-020-04712-5","article-title":"Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment.","volume":"36","author":"Klingler","year":"2020","journal-title":"Childs Nerv Syst."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.prp.2018.05.007","article-title":"Extraneuraxial hemangioblastoma: a clinicopathologic study of 10 cases with molecular analysis of the VHL gene.","volume":"214","author":"Muscarella","year":"2018","journal-title":"Pathol Res Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.21037\/jtd.2018.12.04","article-title":"Mesenchymal tumors of the lung: diagnostic pathology, molecular pathogenesis, and identified biomarkers.","volume":"11","author":"Hashimoto","year":"2019","journal-title":"J Thorac Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/PAP.0000000000000176","article-title":"Extraneuraxial hemangioblastoma: clinicopathologic features and review of the literature.","volume":"25","author":"Bisceglia","year":"2018","journal-title":"Adv Anat Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/PAP.0b013e318286245d","article-title":"Hemangioblastoma-like clear cell stromal tumor of the lung.","volume":"20","author":"Falconieri","year":"2013","journal-title":"Adv Anat Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.15586\/jkcvhl.2017.88","article-title":"A review of Von Hippel-Lindau syndrome.","volume":"4","author":"Varshney","year":"2017","journal-title":"J Kidney Cancer VHL."},{"key":"B7","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/PAS.0000000000001429","article-title":"Hemangioblastoma-like clear cell stromal tumor of the lung: a clinicopathologic and immunohistochemical study of 5 cases.","volume":"44","author":"Lindholm","year":"2020","journal-title":"Am J Surg Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1111\/his.14437","article-title":"YAP1-TFE3 gene fusion variant in clear cell stromal tumour of lung:report of two cases in support of a distinct entity.","volume":"79","author":"Dermawan","year":"2021","journal-title":"Histopathology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/gcc.22073","article-title":"Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma.","volume":"52","author":"Antonescu","year":"2013","journal-title":"Genes Chromosomes Cancer."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1097\/PAS.0000000000001719","article-title":"Recurrent YAP1-TFE3 gene fusions in clear cell stromal tumor of the lung.","volume":"45","author":"Agaimy","year":"2021","journal-title":"Am J Surg Pathol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.836012\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:01:42Z","timestamp":1650258102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.836012\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":10,"alternative-id":["10.3389\/fmed.2022.836012"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.836012","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"article-number":"836012"}}