{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:48:45Z","timestamp":1793256525481,"version":"4.5.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To provide a perspective and surgical video demonstration of peripheral corneal ulceration and perforation managed with multilayered amniotic membrane transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Reports<\/jats:title><jats:p>Case 1 describes a 48-year-old female with progressive redness and pain, and an inferonasal corneal thinning and perforation in the left eye from peripheral ulcerative keratitis. She underwent conjunctival recession with amniotic membrane inlay and onlay (Sandwich technique) transplantation. The amniotic membrane integrated well, and her Snellen visual acuity improved from 6\/21 preoperatively to 6\/9 at 3 months post op. Case 2 describes a 78-year-old male with redness and pain with temporal corneal thinning bilaterally and perforation in the right eye from peripheral ulcerative keratitis. Both eyes underwent similar surgical intervention with smooth integration of the amniotic membrane in the cornea and improvement in the visual acuity. Both patients were also started on systemic immunosuppression in collaboration with the rheumatology team.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report successful use of multilayered amniotic membrane transplantation for the treatment of corneal ulceration and perforation. The authors believe the simplicity of the surgical technique, easier access to amniotic membrane tissue, and lower induced post-operative astigmatism all provide advantages over alternative treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.836873","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T10:16:04Z","timestamp":1651054564000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Case Report: Use of Amniotic Membrane for Tectonic Repair of Peripheral Ulcerative Keratitis With Corneal Perforation"],"prefix":"10.3389","volume":"9","author":[{"given":"Maryam","family":"Eslami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Benito-Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadiah","family":"Goolam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Moloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/ICO.0000000000000128","article-title":"\u201cPleats fold\u201d technique of amniotic membrane transplantation for management of corneal perforations","volume":"33","author":"Namba","year":"2014","journal-title":"Cornea"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.2147\/OPTH.S71102","article-title":"Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital","volume":"8","author":"Yokogawa","year":"2014","journal-title":"Clin Ophthalmol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4238919","DOI":"10.1155\/2020\/4238919","article-title":"Amniotic membrane as a main component in treatments supporting healing and patch grafts in corneal melting and perforations","volume":"2020","author":"Krysik","year":"2020","journal-title":"J Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1097\/ICO.0b013e31820ce80f","article-title":"\u201cSwiss roll\u201d amniotic membrane technique for the management of corneal perforations","volume":"30","author":"Chan","year":"2011","journal-title":"Cornea"},{"key":"B5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3238\/arztebl.2011.0243","article-title":"Amniotic membrane transplantation in the human eye","volume":"108","author":"Meller","year":"2011","journal-title":"Dtsch Arztebl Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5500\/wjt.v4.i2.111","article-title":"Human amniotic membrane transplantation: different modalities of its use in ophthalmology","volume":"4","author":"Malhotra","year":"2014","journal-title":"World J Transplant"},{"key":"B7","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0002-9394(00)00825-4","article-title":"Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera","volume":"131","author":"Hanada","year":"2001","journal-title":"Am J Ophthalmol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S0161-6420(01)01032-6","article-title":"Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers","volume":"109","author":"Solomon","year":"2002","journal-title":"Ophthalmology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1442-9071.2010.02479.x","article-title":"Amniotic membrane transplantation for Mooren's ulcer: amniotic membrane for Mooren's ulcer","volume":"39","author":"Ngan","year":"2011","journal-title":"Clin Exp Ophthalmol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.836873\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T10:16:07Z","timestamp":1651054567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.836873\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":9,"alternative-id":["10.3389\/fmed.2022.836873"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.836873","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"article-number":"836873"}}