{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:13:25Z","timestamp":1793225605800,"version":"4.5.0"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Advanced glycation end products (AGEs) are a series of stable compounds produced under non-enzymatic conditions by the amino groups of biomacromolecules and the free carbonyl groups of glucose or other reducing sugars commonly produced by thermally processed foods. AGEs can cause various diseases, such as diabetes, atherosclerosis, neurodegeneration, and chronic kidney disease, by triggering the receptors of AGE (RAGEs) in the human body. There is evidence that AGEs can also affect the different structures and physiological functions of the skin. However, the mechanism is complicated and cumbersome and causes various harms to the skin. This article aims to identify and summarise the formation and characteristics of AGEs, focussing on the molecular mechanisms by which AGEs affect the composition and structure of normal skin substances at different skin layers and induce skin issues. We also discuss prevention and inhibition pathways, provide a systematic and comprehensive method for measuring the content of AGEs in human skin, and summarise and analyse their advantages and disadvantages. This work can help researchers acquire a deeper understanding of the relationship between AGEs and the skin and provides a basis for the development of effective ingredients that inhibit glycation.<\/jats:p>","DOI":"10.3389\/fmed.2022.837222","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:40:43Z","timestamp":1652254843000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":128,"title":["Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways"],"prefix":"10.3389","volume":"9","author":[{"given":"Chun-yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-miao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-mao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"B1","first-page":"66","article-title":"Action des acides amines sur les sucres; formation des melanoidines par voie methodique.","volume":"154","author":"Maillard","year":"1912","journal-title":"Comptes R Acad Sci (Paris)."},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.semcancer.2017.07.001","article-title":"AGES, Rages and s-Rage; friend or foe for cancer.","volume":"49","author":"Ahmad","year":"2018","journal-title":"Semin Cancer Biol."},{"key":"B3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced glycation end-products: a review.","volume":"44","author":"Singh","year":"2001","journal-title":"Diabetologia."},{"key":"B4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.sjbs.2018.08.024","article-title":"Implications of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs) and other biomarkers in the development of cardiovascular diseases.","volume":"26","author":"Rasool","year":"2019","journal-title":"Saudi J Biol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jdiacomp.2008.04.001","article-title":"Advanced glycation end products in senile diabetic and nondiabetic patients with cataract.","volume":"23","author":"Gul","year":"2009","journal-title":"J Diabetes Complications."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2012.02.018","article-title":"Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective.","volume":"317","author":"Li","year":"2012","journal-title":"J Neurol Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","article-title":"Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury.","volume":"53","author":"Rungratanawanich","year":"2021","journal-title":"Exp Mol Med."},{"key":"B8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.6779377","article-title":"Nonenzymatic browning in vivo: possible process for aging of long-lived proteins.","volume":"211","author":"Monnier","year":"1981","journal-title":"Science."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-016-0176-y","article-title":"Skin disorders in diabetes mellitus: an epidemiology and physiopathology review.","volume":"8","author":"de Macedo","year":"2016","journal-title":"Diabetol Metab Syndr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.cjtee.2017.06.001","article-title":"The molecular biology in wound healing & non-healing wound.","volume":"20","author":"Qing","year":"2017","journal-title":"Chin. 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