{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:02Z","timestamp":1753891202211,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Several cases of pigmented mammary Paget\u2019s disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma <jats:italic>in situ<\/jats:italic> due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease.<\/jats:p>","DOI":"10.3389\/fmed.2022.839954","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T02:51:33Z","timestamp":1648003893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report"],"prefix":"10.3389","volume":"9","author":[{"given":"Shijia","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemuel Shui-Lun","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/00000372-200206000-00001","article-title":"Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.","volume":"24","author":"Requena","year":"2002","journal-title":"Am J Dermatopathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1046\/j.1365-2133.1998.02368.x","article-title":"Pigmented primary carcinoma of the breast: a clinical mimic of malignant melanoma.","volume":"139","author":"Saitoh","year":"1998","journal-title":"Br J Dermatol."},{"key":"B3","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1111\/ijd.14061","article-title":"Pigmented mammary Paget disease mimicking cutaneous melanoma.","volume":"57","author":"Akay","year":"2018","journal-title":"Int J Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/DAD.0000000000001208","article-title":"\u201cPigmented extramammary Paget disease\u201d\u2013a potential mimicker of malignant melanoma and a pitfall in diagnosis: a case report and review of the literature.","volume":"41","author":"Kiavash","year":"2019","journal-title":"Am J Dermatopathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1111\/1346-8138.13684","article-title":"Pigmented extramammary Paget\u2019s disease: pitfalls of diagnosis.","volume":"44","author":"Nagano","year":"2017","journal-title":"J Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jaad.2009.12.059","article-title":"Pigmented mammary Paget disease positive for melanocytic markers.","volume":"65","author":"Park","year":"2011","journal-title":"J Am Acad Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/ajcp\/92.4.491","article-title":"Breast carcinoma with positive results for melanoma marker (HMB-45). 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