{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:42Z","timestamp":1753891302585,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Gastric-type endocervical adenocarcinoma (GAS) is considered a distinct and clinically important entity because it is unrelated to human papillomavirus infection and has aggressive behavior and worse clinical outcomes than the usual type of endocervical adenocarcinoma (ECA). The preoperative diagnosis of GAS is often difficult because of its nonspecific clinical manifestations and special lesion location. We report the case of a 50-year-old Chinese woman who presented with intermittent left lower abdominal pain for 1 year. Preoperative images showed left hydrosalpinx and a lesion that was mainly located in the lower part of the uterine cavity. We considered the lesion to be a polyp before surgery. During hysteroscopic surgery, we suspected that it may be a submucosal myoma. However, pathology revealed that it was a GAS. GAS may be located in the upper endocervix or even reach the uterine cavity. The appearance is occasionally similar to that of submucosal myoma, resulting in difficult preoperative diagnosis and even misdiagnosis.<\/jats:p>","DOI":"10.3389\/fmed.2022.845445","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T05:00:53Z","timestamp":1646715653000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Gastric-Type Endocervical Adenocarcinoma Mimicking Submucosal Myoma Under Hysteroscopy"],"prefix":"10.3389","volume":"9","author":[{"given":"Jiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.21873\/invivo.12499","article-title":"Clinicopathological characteristics of gastric-type endocervical adenocarcinoma misdiagnosed as an endometrial, ovarian or extragenital malignancy, or mistyped as usual-type endocervical adenocarcinoma","volume":"35","author":"Koh","year":"2021","journal-title":"In Vivo."},{"key":"B2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/gyno.2000.5826","article-title":"The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States\u2013a 24-year population-based study","volume":"78","author":"Smith","year":"2000","journal-title":"Gynecol Oncol."},{"volume-title":"WHO Classification of Tumours:Female Genital Tumours","year":"2020","key":"B3"},{"key":"B4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/pas.0000000000000986","article-title":"International endocervical adenocarcinoma criteria and classification (IECC): a new pathogenetic classification for invasive adenocarcinomas of the endocervix","volume":"42","author":"Stolnicu","year":"2018","journal-title":"Am J Surg Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1097\/pas.0000000000000532","article-title":"Gastric-type endocervical adenocarcinoma: an aggressive tumor with unusual metastatic patterns and poor prognosis","volume":"39","author":"Karamurzin","year":"2015","journal-title":"Am J Surg Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/01.pas.0000213434.91868.b0","article-title":"Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix","volume":"31","author":"Kojima","year":"2007","journal-title":"Am J Surg Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/s41379-020-00726-1","article-title":"Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations","volume":"34","author":"Selenica","year":"2021","journal-title":"Mod Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ygyno.2019.01.022","article-title":"Analysis of gastric-type mucinous carcinoma of the uterine cervix - 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